Elucidation of the mechanism of development of different types of aneurysm
Project/Area Number |
25461142
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Juntendo University (2014-2015) National Defense Medical College (2013) |
Principal Investigator |
Isoda Kikuo 順天堂大学, 医学部, 准教授 (00532475)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 動脈瘤 / 炎症 / サイトカイン / 骨髄 / DPP-4阻害 / アンジオテンシンII / DPP-4阻害薬 / 抗炎症性サイトカイン / 炎症細胞 |
Outline of Final Research Achievements |
We detected that the IL-1Ra present in both bone marrow (BM)-derived cells and non-BM cells helps to suppress arterial inflammation and promote re-endothelialization, thus resulting in decreased neointimal formation and development of aneurysm. These novel findings shed new light on the mechanisms underlying the development of aneurysm. We also revealed that a dipeptidyl‐peptidase‐4 inhibitor appeared to suppress neointimal formation by inhibiting inflammation, independently of its effects on glucose or cholesterol metabolism in mice. We have published these articles.
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Report
(4 results)
Research Products
(13 results)