Investigation of inhalation effects and mechanisms on diaphragm muscle contractility
Project/Area Number |
25461144
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Tohoku University |
Principal Investigator |
Shindoh Chiyohiko 東北大学, 医学(系)研究科(研究院), 教授 (10216228)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 吸入ステロイド剤(ICS) / 長時間作動性交感神経刺激剤(LABA) / 一酸化窒素(NO) / 気管支喘息 / 慢性閉塞性肺疾患(COPD) / 横隔膜筋 / 吸入ステロイド剤(ICS) / 吸入ステロイド剤(ICS) / 長時間作動性交感神経刺激剤(LABA) / 一酸化窒素 (NO) |
Outline of Final Research Achievements |
We investigated inhalation effects on diaphragm muscle contractility using a combination of inhaled corticosteroid (ICS) and long-acting β2- agonist (LABA), and a long-acting muscarinic antagonist (LAMA). The ICS/LABA inhalation significantly increased force-frequency (F/f) curves at 1 h after inhalation. Endotoxin injection resulted in a downward shift in F/f curves at 4 h and induced NO production, however ICS/LABA inhalation prevented endotoxin effects. These results indicate that the inhalation of ICS/LABA potentiates diaphragm muscle contractility, and it seems a benefit for the patients with bronchial asthma.We also investigated inhalation effects of long-acting muscarinic antagonist (LAMA). LAMA inhalation induced an increase of muscle contractility at 4 h after its inhalation and inhibited the effects of endotoxin by reducing NO production. These results indicate that LAMA is beneficial for the patients with COPD because it helps prevent diaphragm muscle weakness.
|
Report
(4 results)
Research Products
(29 results)
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[Journal Article] Effect of Carbenoxolone on Arrhythmogenesis in Rat Ventricular Muscle2016
Author(s)
Masahito Miura, Tsuyoshi Nagano, Naomi Murai, Yuhto Taguchi, Tetsuya Handoh, Minami Satoh, Satoshi Miyata, Lawson Miller, Chiyohiko Shindoh, Bruno D. Stuyvers
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Journal Title
Circulation Journal
Volume: 80
Issue: 1
Pages: 76-84
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Modified Cut-Off Value of the Urine Protein-To-Creatinine Ratio Is Helpful for Identifying Patients at High Risk for Chronic Kidney Disease: Validation of the Revised Japanese Guideline2015
Author(s)
Hiroyuki Yamamoto, Kyoko Yamamoto, Katsumi Yoshida, Chiyohiko Shindoh, Kyoko Takeda, Masami Monden, Hiroko Izumo, Hiroyuki Niinuma, Yutaro Nishi, Koichiro Niwa and Yasuhiro Komatsu
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 237
Issue: 3
Pages: 201-207
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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[Journal Article] The total urine protein-to-creatinine ratio can predict the presence of microalbuminuria.2014
Author(s)
Kyoko Yamamoto, Hiroyuki Yamamoto, Katsumi Yoshida, Koichiro Niwa, Yutaro Nishi, Atsushi Mizuno, Masanari Kuwabara, Taku Asano, Kunihiro Sakoda, Hiroyuki Niinuma, Fumiko Nakahara, Kyoko Takeda, Chiyohiko Shindoh, Yasuhiro Komatsu.
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Journal Title
PLOS ONE
Volume: 9
Issue: 3
Pages: e91067-e91067
DOI
Related Report
Peer Reviewed
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