| Project/Area Number |
25461147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIZAWA NOBUYUKI 筑波大学, 医学医療系, 教授 (00301896)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 喘息 / 慢性閉塞性肺疾患 / 前向き研究 / 遺伝子多型 / COPD / 肺機能 / 遺伝多型 / ゲノムワイド関連解析 / IgE |
|---|
| Outline of Final Research Achievements |
A follow-up survey of 1312 healthy volunteers for 5 years demonstrated 35 new-onset asthma and 11 COPD patients. FEV1/FVC in the COPD group was significantly lower than that in the control group. Heretabilities for %FVC, %FEV1, and FEV1/FVC were estimated to be 71, 52, and 42%, respectively. Then, genome-wide association study using the healthy volunteers and asthma patients suggested that HAS2 and HCG22 are associated with the development of asthma.
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