Comprehensive analysis of risk factors for asthma and COPD by prospective cohort study
Project/Area Number |
25461147
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HIZAWA NOBUYUKI 筑波大学, 医学医療系, 教授 (00301896)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 喘息 / 慢性閉塞性肺疾患 / 前向き研究 / 遺伝子多型 / COPD / 肺機能 / 遺伝多型 / ゲノムワイド関連解析 / IgE |
Outline of Final Research Achievements |
A follow-up survey of 1312 healthy volunteers for 5 years demonstrated 35 new-onset asthma and 11 COPD patients. FEV1/FVC in the COPD group was significantly lower than that in the control group. Heretabilities for %FVC, %FEV1, and FEV1/FVC were estimated to be 71, 52, and 42%, respectively. Then, genome-wide association study using the healthy volunteers and asthma patients suggested that HAS2 and HCG22 are associated with the development of asthma.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations.2016
Author(s)
Yatagai Y, Hirota T, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Tamari M, Kubo M, Takahashi A, Konno S, Makita H, Nishimura M, Hijikata M, Keicho N, Homma S, Taguchi Y, Azuma A, Kudoh S, Hizawa N.
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Journal Title
J Allergy Clin Immunol
Volume: 印刷中
Issue: 1
Pages: 281-283
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] FACTORS ASSOCIATED WITH THE PRESENCE OF ALLERGEN-SPECIFIC IgE RESPONSES IN ASTHMA PATIENTS WHO HAD NO IgE RESPONSES DETECTABLE BY MAST-262015
Author(s)
Iijima H, Kaneko Y, Masuko H, Yamada H, Yatagai Y, Sakamoto T, Kanemoto K, Ishikawa H, Saito T, Endo T, Ninomiya H, Nomura A, Kodama T, Kaneko N, Kokubu F, Makita H, Konno S, Nishimura M, Hizawa N
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Journal Title
Japanese Journal of Allergology
Volume: 64
Issue: 9
Pages: 1242-1253
DOI
NAID
ISSN
0021-4884, 1347-7935
Related Report
Peer Reviewed
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[Journal Article] Role of Lung Function Genes in the Development of Asthma2015
Author(s)
Yamada H, Masuko H, Yatagai Y, Sakamoto T, Kaneko Y, Iijima H, Naito T, Noguchi E, Konno S, Nishimura M, Hirota T, Tamari M, Hizawa N
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Journal Title
PLoS One
Volume: -
Issue: 1
Pages: e0145832-e0145832
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The effects of a Gly16Arg ADRB2 polymorphism on responses to salmeterol or montelukast in Japanese patients with mild persistent asthma2014
Author(s)
Konno S, Hizawa N, Makita H, Shimizu K, Sakamoto T, Kokubu F, Saito T, Endo T, Ninomiya H, Iijima H, Kaneko N, Ito YM, Nishimura M
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Journal Title
Pharmacogenet Genomics
Volume: 24
Issue: 5
Pages: 246-255
DOI
Related Report
Peer Reviewed
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[Journal Article] アレルゲン特異的IgE反応性から分類した喘息フェノタイプ―Thymic stromal lymphopoietin(TSLP)遺伝子と喫煙の役割―2014
Author(s)
飯島弘晃, 山田英恵, 谷田貝洋平, 金子美子, 内藤隆志, 坂本 透, 増子裕典, 広田朝光, 玉利真由美, 今野 哲, 西村正治, 檜澤伸之
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Journal Title
アレルギー
Volume: 63
Pages: 33-44
NAID
Related Report
Peer Reviewed
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[Journal Article] Genomewide association study identifies HAS2 as a novel susceptibility gene for adult asthma in a Japanese population2014
Author(s)
Yatagai Y, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Konno S, Nishimura M, Hizawa N
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Journal Title
Clin Exp Allergy
Volume: 44
Issue: 11
Pages: 1327-1334
DOI
Related Report
Peer Reviewed
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[Presentation] Genome-wide association study for late-onset asthma demonstrates possible association with a gene related to diffuse panbronchiolitis2015
Author(s)
Yatagai Y, Sakamoto T, Ymada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Makita H, Konno S, Nishimura M, Hizawa N.
Organizer
American Thoracic Society 2015 International Conference
Place of Presentation
Colorado Convention Center (Denver)
Year and Date
2015-05-15
Related Report
Int'l Joint Research
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[Presentation] The role of pulmonary function genes in the pathogenesis of asthma2015
Author(s)
Ymada H, Yatagai Y, Masuko H, Kaneko Y, Sakamoto T, Iijima H, Naito T, Noguchi E, Konno S, Nishimura M, Hirota T, Tamari M, Hizawa N.
Organizer
American Thoracic Society 2015 International Conference
Place of Presentation
Colorado Convention Center (Denver)
Year and Date
2015-05-15
Related Report
Int'l Joint Research
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[Presentation] A Genomewide Association Study In Healthy Japanese Adults Replicated The Previously Reported Susceptibility Genes To Airflow Limitation.2013
Author(s)
Yamada H, Yatagai Y, Masuko H, Kaneko Y, Sakamoto T, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Hizawa N.
Organizer
American Thoracic Society 2013 International Conference
Place of Presentation
Pennsylvania Convention Center(USA)
Related Report
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[Presentation] Genome-Wide Association Study Of Serum Total IgE Levels In The Japanese Population Identifies A Novel Responsible Locus In HLA Class I Region.2013
Author(s)
Yatagai Y, Masuko H, Yamada H, Kaneko Y, Sakamoto T, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Imoto Y, Tokunaga T, Konno S, Nishimura M, Hizawa N.
Organizer
American Thoracic Society 2013 International Conference
Place of Presentation
Pennsylvania Convention Center(USA)
Related Report
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