• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biomarker targeting pulmonary vaculopathy of pulmonary hypertension and association of them with gene polymorphism

Research Project

Project/Area Number 25461148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionChiba University

Principal Investigator

Tanabe Nobuhiro  千葉大学, 医学(系)研究科(研究院), 特任教授 (40292700)

Co-Investigator(Kenkyū-buntansha) SAKAO SEIICHIRO  千葉大学, 医学部附属病院, 講師 (80431740)
Co-Investigator(Renkei-kenkyūsha) SATO TORU  杏林大学, 医学部, 教授 (20170764)
NAKANISHI NORIHUMI  独立行政法人国立循環器病研究センター, 心臓内科, 部長 (80164234)
UEDA HATSUE  独立行政法人国立循環器病研究センター, 病理部臨床病理科, 部長 (40522983)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肺高血圧症 / 慢性血栓塞栓性肺高血圧症 / 肺動脈性肺高血圧症 / バイオマーカー / オーダーメード治療 / 右心機能 / 個別化医療
Outline of Final Research Achievements

The purpose of this study is to elucidate new pulmonary vascular biomarkers ; to find association of them with severity of pulmonary hypertension, surgical outcome in chronic thromboembolic pulmonary hypertension (CTEPH), prognosis; to investigate the association of activity of the biomarkers and gene polymorphism for personalized medicine. Pentlaxin-3 (PTX-3) was the most sensitive biomarker of CTEPH and may be useful marker for early diagnosis, although PTX3 levels did not correlate with the severity of the pulmonary hemodynamics even stratified by gene polymorphisms. Preoperatively high fibrinogen and low plasminogen values in CTEPH are associated with poor long-term postoperative outcome. For PET, accumulation on pulmonary arterial wall was high in some of CTEPH, but the level of SUV max was lower than sarcoma of the pulmonary artery. Finally we found 4 new pulmonary specific peptide biomarkers associated with CTEPH using the protein array method for screening of autoantibodies.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (45 results)

All 2016 2015 2014 2013

All Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 10 results,  Acknowledgement Compliant: 7 results) Presentation (15 results) (of which Int'l Joint Research: 1 results,  Invited: 10 results) Book (15 results)

  • [Journal Article] Mean Pulmonary Artery Pressure Using Echocardiography in Chronic Thromboembolic Pulmonary Hypertension.2016

    • Author(s)
      Kasai H, Matsumura A, Sugiura T, Shigeta A, Tanabe N, Yamamoto K, Miwa H, Ema R, Sakao S, Tatsumi K.
    • Journal Title

      Cir J.

      Volume: 80

    • NAID

      130005147668

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.2016

    • Author(s)
      Nishimura R, Tanabe N, Sekine A, Kasai H, Suda R, Kato F, Jujo T, Sugiura T, Shigeta A, Sakao S, Tatsumi K.
    • Journal Title

      Respiration

      Volume: 91 Issue: 2 Pages: 132-149

    • DOI

      10.1159/000443772

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Coagulation-Fibrinolysis System and Postoperative Outcomes of Patients With Chronic Thromboembolic Pulmonary Hypertension2016

    • Author(s)
      Kato F, Tanabe N, Ishida K, Suda R, Sekine A, Nishimura R, Jujo T, Sugiura T, Sakao S, Tatsumi K.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 4 Pages: 970-979

    • DOI

      10.1253/circj.CJ-15-1208

    • NAID

      130005139583

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of the Microcirculation in Chronic Thromboembolic Pulmonary Hypertension Patients: The Impact of Pulmonary Arterial Remodeling on Postoperative and Follow-Up Pulmonary Arterial Pressure and Vascular Resistance.2015

    • Author(s)
      Jujo T, Sakao S, Ishibashi-Ueda H, Ishida K, Naito A, Sugiura T, Shigeta A, Tanabe N, Masuda M, Tatsumi K.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 9 Pages: e0138040-e0138040

    • DOI

      10.1371/journal.pone.0138040

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of Surgical and Medical Treatment on Quality of Life for Patients With Chronic Thromboembolic Pulmonary Hypertension2015

    • Author(s)
      Urushibara T, Tanabe N, Suda R, Kato F, Kasai H, Takeuchi T, Sekine A, Nishimura R, Jujo T, Sugiura T, Shigeta A, Sakao S, Kasahara Y, Tatsumi K.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 12 Pages: 2696-2702

    • DOI

      10.1253/circj.CJ-15-0538

    • NAID

      130005110925

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pentraxin3 in chronic thromboembolic pulmonary hypertension: a new biomarker for screening from remitted pulmonary thromboembolism.2014

    • Author(s)
      Naito A, Tanabe N, et al.
    • Journal Title

      PLoS One.

      Volume: 9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of Plasma Fibrinogen and Plasminogen With Prognosis of Inoperable Chronic Thromboembolic Pulmonary Hypertension2014

    • Author(s)
      Kato F, Tanbe N, et al.
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 7 Pages: 1754-1761

    • DOI

      10.1253/circj.CJ-13-1535

    • NAID

      130004926958

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Electrocardiogram-gated 320-slice multidetector computed tomography for the measurement of pulmonary arterial distensibility in chronic thromboembolic pulmonary hypertension.2014

    • Author(s)
      Kasai H, Sugiura T, Tanabe N, et al.
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] Current trends in the management of pulmonary hypertension associated with respiratory disease in institutions approved by the Japanese Respiratory Society.2014

    • Author(s)
      Tanabe N, et al.
    • Journal Title

      Respir Investig

      Volume: 52 Issue: 3 Pages: 167-172

    • DOI

      10.1016/j.resinv.2013.11.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term Survival of Japanese Patients with Pulmonary Arterial Hypertension Treated with Beraprost Sodium, an Oral Prostacyclin Analogue2014

    • Author(s)
      Sakao S, Tanabe N, et al.
    • Journal Title

      Internal Medicine

      Volume: 53 Issue: 17 Pages: 1913-1920

    • DOI

      10.2169/internalmedicine.53.2573

    • NAID

      130004685050

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polymorphism of the G protein β3 subunit gene influences the efficacy of sildenafil in patients with pulmonary hypertension2014

    • Author(s)
      Sekne A, Tanabe N, et al.
    • Journal Title

      Intern Med

      Volume: 53 Pages: 291-297

    • NAID

      130003392648

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent progress in the diagnosis and management of chronic thromboembolic pulmonary hypertension2013

    • Author(s)
      Tanabe N, et al.
    • Journal Title

      Respir Investig

      Volume: 51 Issue: 3 Pages: 134-136

    • DOI

      10.1016/j.resinv.2013.02.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improved survival in medically treated chronic thromboembolic pulmonary hypertension2013

    • Author(s)
      Nishimura R, Tanabe N, et al.
    • Journal Title

      CIr J

      Volume: 77 Pages: 2110-2117

    • NAID

      10031178683

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Myocardial fibrosis in the right ventricle detected on ECG gated 320 slice CT showed a short term poor prognosis in subjects with pulmonary hypertension.2013

    • Author(s)
      Ozawa K, Funabashi N, Kataoka A, Tanabe N, et al.
    • Journal Title

      Int J Cardiol

      Volume: 168 Pages: 584-586

    • Related Report
      2013 Research-status Report
  • [Journal Article] Role of 320-slice CT imaging in the diagnostic workup of patients with chronic thromboembolic pulmonary hypertension2013

    • Author(s)
      Sugiura T, Tanabe N, et al.
    • Journal Title

      Chest

      Volume: 143 Pages: 1070-1077

    • Related Report
      2013 Research-status Report
  • [Presentation] 画像での鑑別が困難であった肺動脈原発肉腫7例と慢性血栓塞栓性肺高血圧症2例の検討2016

    • Author(s)
      須田 理香、田邊 信宏、堀越 琢郎、石田敬一、漆原 崇司、加藤 史照、笠井 大、竹内 孝夫、関根 亜由美、西村 倫太郎、重城 喬行、杉浦 寿彦、坂尾 誠一郎、巽 浩一郎
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      京都国際会館(京都府, 京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diagnosis of Chronic Thromboembolic Pulmonary Hypertension and Indication for Balloon Pulmonary Angioplasty2016

    • Author(s)
      田邉 信宏
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県, 仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Pathogenesis and treatment updates on chronic thromboembolic pulmonary hypertension.2015

    • Author(s)
      Nobuhiro Tanabe
    • Organizer
      The 20th Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Kuala Lumpur( Malaysia)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diagnosis and medical treatment of chronic thoromboembolic pulmonary hypertension2015

    • Author(s)
      Nobuhiro Tanabe
    • Organizer
      第 79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府, 大阪市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 慢性血栓塞栓性肺高血圧症における炎症・心筋関連バイオマーカーと血行動態の検討.2015

    • Author(s)
      内藤 亮、田邉 信宏、重城 喬行、重田 文子、 杉浦 寿彦、 坂尾 誠一郎、 巽 浩一郎.
    • Organizer
      第112回日本内科学会総会・講演会
    • Place of Presentation
      みやこメッセ(京都府, 京都市)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Recent strategies for chronic thromboembolic pulmonary hypertension.2014

    • Author(s)
      Noburhiro Tanabe
    • Organizer
      19thCongress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺動脈性肺高血圧症2014

    • Author(s)
      田邊信宏
    • Organizer
      第24回日本呼吸ケア・リハビリテーション学会学術集会
    • Place of Presentation
      奈良県 奈良市 なら100年会館
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺高血圧症の早期診断と包括的治療―リハビリの意義も含めて―2014

    • Author(s)
      田邉信宏
    • Organizer
      第24回日本呼吸ケア・リハビリテーション学会学術集会
    • Place of Presentation
      奈良県 奈良市 なら100年会館
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺高血圧症ガイドラインを巡って~ニース会議を踏まえて~2014

    • Author(s)
      田邊信宏
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪府 大阪市 大阪国際会議場
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺動脈性肺高血圧症/肺静脈閉塞症の病態と治療の展望2014

    • Author(s)
      田邉信宏
    • Organizer
      第111回日本内科学会総会・講演会
    • Place of Presentation
      東京都 東京国際フォーラム
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Distal pulmonary vascular remodeling in the patients with chronic thromboembolic pulmonary hypertension (CTEPH)2013

    • Author(s)
      ujo T, Sakao S, Ueda H, Ishida K, Sugiura T, Kasahara Y, Tanabe N, et al.
    • Organizer
      American Thoracic Society International Conference 2013
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 慢性血栓塞栓性肺高血圧症のUp-to-date:診断からの治療2013

    • Author(s)
      田邉信宏
    • Organizer
      第1回日本肺高血圧学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 慢性血栓塞栓性肺高血圧症の病因と病態.2013

    • Author(s)
      田邉信宏
    • Organizer
      第1回日本肺高血圧学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 慢性血栓塞栓性肺高血圧症の診断・病勢評価における320列CTの有用性についての検討.2013

    • Author(s)
      杉浦寿彦, 田辺信宏, 他.
    • Organizer
      第110回日本内科学会講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 可溶性CD40リガンド濃度とCOPD重症度の相関.2013

    • Author(s)
      12. 重田文子, 多田裕司, 家里憲, 笠原靖紀, 滝口裕一, 田邉信宏, 巽浩一郎.
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] 肺高血圧症(肺動脈性肺高血圧症、呼吸器疾患に伴う肺高血圧症など)呼吸器病レジデントマニュアル 第5版2015

    • Author(s)
      田邉 信宏、谷口 博之、藤田 次郎
    • Total Pages
      644
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 肺血栓塞栓症, 肺梗塞. 新呼吸器専門医テキスト2015

    • Author(s)
      田邉 信宏、高橋 弘毅、長谷川 好規
    • Total Pages
      598
    • Publisher
      南江堂
    • Related Report
      2015 Annual Research Report
  • [Book] 肺血栓塞栓症 今日の診断指針第7版2015

    • Author(s)
      田邉 信宏、金澤 一郎、永井 良三
    • Total Pages
      2103
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] Q22その他の疾患や要因による肺高血圧症にはどのようなものがあるのでしょうか。それぞれの特徴、治療指針と予後を教えてください. ~早期診断・治療のための~ 肺高血圧症Q&A.2015

    • Author(s)
      田邉 信宏 、福田 恵一
    • Total Pages
      261
    • Publisher
      先端医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 慢性血栓塞栓性肺高血圧症の診断と内科的治療 最新醫學 別冊 診断と治療のABC104 肺高血圧症2015

    • Author(s)
      田邉 信宏、巽 浩一郎
    • Total Pages
      221
    • Publisher
      最新医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 肺動脈性肺高血圧症. 2014今日の治療指針.私はこう治療している.2014

    • Author(s)
      田邉信宏
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Book] 肺高血圧症. 2014 Annual Review 呼吸器.2014

    • Author(s)
      杉浦寿彦、田邉信宏
    • Total Pages
      6
    • Publisher
      中外医学社
    • Related Report
      2014 Research-status Report
  • [Book] 肺血栓塞栓症. 肺循環に起因する肺疾患 呼吸器疾患診療最新ガイドライン.2014

    • Author(s)
      田邉信宏
    • Total Pages
      7
    • Publisher
      総合医学社
    • Related Report
      2014 Research-status Report
  • [Book] 肺循環障害.肺循環障害と肺血栓塞栓症.2014

    • Author(s)
      田邉信宏
    • Total Pages
      4
    • Publisher
      アトムス
    • Related Report
      2014 Research-status Report
  • [Book] 治療の進歩 肺高血圧症に対するUpfront combination therapy. 2014 Annual Review 呼吸器.2014

    • Author(s)
      須田理香、田邉信宏、巽浩一郎
    • Total Pages
      8
    • Publisher
      中外医学社
    • Related Report
      2014 Research-status Report
  • [Book] 肺高血圧症治療ガイドライン(2012年改訂版)2013

    • Author(s)
      中西宣文他 田邉信宏
    • Total Pages
      69
    • Publisher
      日本循環器学会, 日本呼吸器学会, 他
    • Related Report
      2013 Research-status Report
  • [Book] 肺循環系疾患 内科学書改訂第8版Vol.22013

    • Author(s)
      田邉信宏
    • Total Pages
      5
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report
  • [Book] 肺性心 内科学書改訂第8版Vol.22013

    • Author(s)
      田邉信宏
    • Total Pages
      4
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report
  • [Book] 慢性血栓塞栓性肺高血圧症2013

    • Author(s)
      田邉信宏
    • Total Pages
      13
    • Publisher
      医薬ジャーナル出版
    • Related Report
      2013 Research-status Report
  • [Book] 肺高血圧症―新たな診断基準と治療戦略2013

    • Author(s)
      田邉信宏
    • Total Pages
      5
    • Publisher
      南江堂
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi