A role of anti-CADM-140/MDA5 antibodies in rapidly progressive interstitial lung disease associated with amyopathic dermatomyositis
| Project/Area Number |
25461151
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKAGAMI Takuro 新潟大学, 医歯学系, 助教 (00444159)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 皮膚筋炎 / 間質性肺炎 / 抗CADM-140/MDA5抗体 / サイトカイン / CX3CL1 |
|---|
| Outline of Final Research Achievements |
Patients with amyopathic dermatomyositis (ADM) sometimes develop rapidly progressive interstitial lung disease (ILD). Although anti-CADM-140/MDA5 antibody titer could predict the course of ADM-ILD, it is not clear how this antibody is involved in the pathogenesis of the disease. We retrospectively collected clinical records and preserved serum before treatment of consecutive patients with ADM-ILD since 2000 to 2014. Of 13 patients enrolled, four did not respond to therapy and died. The mean anti-CADM-140/MDA5 antibody titer was significantly higher in patients who did not responded (p<0.05). Then we measured serum cytokine/growth factor (GF) protein concentration using a multiplex immunoassay system. Relationship analyses between the antibody titer and each cytokine/GF protein concentration revealed that Spearman's rank correlation coefficients were more than 0.4 in 13 cytokine/GF proteins. The strongest correlation was found between the antibody titer and CX3CL1 (r=0.8897).
|
Report
(4 results)
Research Products
(18 results)
-
-
-
-
-
-
-
[Journal Article] An observational study of giant cell interstitial pneumonia and lung fibrosis in hard metal lung disease2014
Author(s)
Junichi Tanaka1, Hiroshi Moriyama1, Masaki Terada1, Toshinori Takada1,2, Eiichi Suzuki3, Ichiei Narita1, Yoshinori Kawabata4, Tetsuo Yamaguchi4, Akira Hebisawa4, Fumikazu Sakai4, Hiroaki Arakawa4
-
Journal Title
BMJ Open
Volume: 4
Issue: 3
Pages: e004407-e004407
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Secondary pulmonary alveolar proteinosis complicating myelodysplastic syndrome results in worsening of prognosis: a retrospective cohort study in Japan2014
Author(s)
Haruyuki Ishii, John F Seymour, Ryushi Tazawa, Yoshikazu Inoue, Naoyuki Uchida, Aya Nishida, Yoshihito Kogure, Takeshi Saraya, Keisuke Tomii, Toshinori Takada, Yuko Itoh, Masayuki Hojo, Toshio Ichiwata, Hajime Goto, Koh Nakata
-
Journal Title
BMC Pulmonary Medicine
Volume: 14: 37
Issue: 1
Pages: 1471-2466
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Duration of benefit in patients with autoimmune pulmonary alveolar proteinosis after inhaled granulocyte-macrophage colony-stimulating factor therapy.2014
Author(s)
Tazawa R, Inoue Y, Arai T, Takada T, Kasahara Y, Hojo M, Ohkouchi S, Tsuchihashi Y, Yokoba M, Eda R, Nakayama H, Ishii H, Nei T, Morimoto K, Nasuhara Y, Ebina M, Akira M, Ichiwata T, Tatsumi K, Yamaguchi E, Nakata K.
-
Journal Title
Chest
Volume: 145
Issue: 4
Pages: 729-737
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
