How GM-CSF inhalation improves clinical and biological factors in pulmonary alveolar proteinosis?
Project/Area Number |
25461153
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Niigata University |
Principal Investigator |
Tazawa Ryushi 新潟大学, 医歯学総合病院, 准教授 (70301041)
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Co-Investigator(Kenkyū-buntansha) |
Nakata Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
Ishii Haruyuki 杏林大学, 医学部呼吸器内科, 准教授 (30406970)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 肺胞蛋白症 / GM-CSF / 抗GM-CSF抗体 / 気管支肺胞洗浄液 / 抗GM-CSF自己抗体 |
Outline of Final Research Achievements |
In this study, we approached therapeutic mechanisms of GM-CSF inhalation, a novel therapy for autoimmune pulmonary alveolar proteinosis. The studies on CT images of the patients, who underwent GM-CSF inhalation therapy, revealed that including intensity of the opacities to CT grading was useful for evaluating therapeutic response, suggesting improvement of intensity rather than extent of the opacities of more importance. Follow-up observation of the patients demonstrated that baseline %VC might be a prognostic factor for disease recurrence. Reduction of VC might be due to accumulation of surfactant-derived materials in the alveolar space, while fibrotic changes were not remarkable in the CT images of the patients. Notably, the CT grading also had significant correlation with serum markers such as SP-D and KL-6. Comparison of recombinant human GM-CSF derived from cells of three species revealed that sialylated oligosaccharide moieties prolong the bioactivity of rhGM-CSF in vitro.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study2015
Author(s)
Keiichi Akasaka, Takahiro Tanaka, Nobutaka Kitamura, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Toshio Ichiwata, Etsuro Yamaguchi, Masaki Hirose, Toru Arai, Kentaro Nakano, Takahito Nei, Haruyuki Ishii, Tomohiro Handa, Yoshikazu Inoue and Koh Nakata
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Journal Title
BMC Pulmonary Medicine
Volume: 15
Issue: 1
Pages: 88-88
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome.2015
Author(s)
Moriyama M, Yano T, Furukawa T, Takada T, Ushiki T, Masuko M, Takizawa J, Sone H, Tazawa R, Saijo Y, Ishii H, Nakata K.
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Journal Title
Ann Am Thorac Soc.
Volume: 12
Pages: 1251-1253
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Duration of benefit in patients with autoimmune pulmonary alveolar proteinosis after inhaled granulocyte-macrophage colony-stimulating factor therapy.2014
Author(s)
Tazawa R, Inoue Y, Arai T, Takada T, Kasahara Y, Hojo M, Ohkouchi S, Tsuchihashi Y, Yokoba M, Eda R, Nakayama H, Ishii H, Nei T, Morimoto K, Nasuhara Y, Ebina M, Akira M, Ichiwata T, Tatsumi K, Yamaguchi E, Nakata K.
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Journal Title
Chest
Volume: 145
Issue: 4
Pages: 729-737
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Light chain (κ/λ) ratio of GM-CSF autoantibodies is associated with disease severity in autoimmune pulmonary alveolar proteinosis.2013
Author(s)
Nei T, Urano S, Itoh Y, Kitamura N, Hashimoto A, Tanaka T, Motoi N, Kaneko C, Tazawa R, Nakagaki K, Arai T, Inoue Y, Nakata K.
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Journal Title
Clin Immunol
Volume: 149(3)
Issue: 3
Pages: 357-364
DOI
Related Report
Peer Reviewed
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[Presentation] The Analysis of alveolar macrophage form on BALF specimens in secondary pulmonary alveolar proteinosis2015
Author(s)
H. Ishii, R. Tazawa, Y. Inoue, T. Saraya, T. Koide, T. Handa, M. Morita, S. Yamamoto, Y. Tanino, S. Ohkouchi, K. Tomii, K. Nakata
Organizer
American Thporacic Society International Conference 2015
Place of Presentation
コロラドコンベンションセンター(米国コロラド州デンバー市)
Year and Date
2015-05-19
Related Report
Int'l Joint Research
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[Presentation] Rare Lung Diseases2014
Author(s)
Tazawa R
Organizer
19th Congress of Asian Pacific Society of Respirology
Place of Presentation
Bali International Convention Centre, Nusa Dua, Bali, Indonesia
Year and Date
2014-11-15
Related Report
Invited
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[Presentation] Adult-Onset Hereditary Pulmonary Alveolar Proteinosis Caused By CSF2RA Deletion2014
Author(s)
R. Tazawa, K. Ito, T. Ogi, H. Ishii, T. Sakagami, Y. Ito, A. Hashimoto, T. Tanaka, K.-I. Akasaka, J. Tohyama, K. Nakata
Organizer
Annual Meeting of American Thoracic Society 2014
Place of Presentation
San Diego Convention Center, San Diego, CA, USA
Year and Date
2014-05-18
Related Report
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