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Possible mechanism of parenchymal destruction on the analogy of image analysis

Research Project

Project/Area Number 25461156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

Shigeo Muro  京都大学, 医学(系)研究科(研究院), 講師 (60344454)

Co-Investigator(Kenkyū-buntansha) SATO ATSUYASU  京都大学, 医学研究科, 特定病院助教 (30706677)
Co-Investigator(Renkei-kenkyūsha) NAKAMURA TOMOYUKI  関西医科大学, 医学研究科, 教授 (20362527)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords呼吸器内科 / 肺気腫 / 細胞外マトリクス / 炎症 / 画像解析 / 臨床呼吸器学 / COPD / 再生医療 / 気道炎症 / 細胞外マトリックス / 免疫 / 慢性閉塞性肺疾患
Outline of Final Research Achievements

In our COPD prospective observational clinical study, we recruited 82 COPD subjects. Preliminary analysis showed that humoral immunity influence the frequency of COPD exacerbations. The observation period will complete at the end of June 2016, and we will finalize the data and analyze the final data. At the same time, we established the model mouse of the pulmonary emphysema by giving a small amount of proteolytic enzyme in the respiratory tract. We tried to prevent emphysema development by adding elastic fiber synthetic related protein in the lung, however, we could not find strong evidence that our method could prevent emphysema in the whole lung. However, the pathology showed that some destroyed lung field were repaired by new lung cells. We will continue to study this repair process and try to establish new regenerative method in COPD treatment.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (50 results)

All 2016 2015 2014 2013

All Journal Article (16 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (26 results) (of which Int'l Joint Research: 2 results,  Invited: 8 results) Book (8 results)

  • [Journal Article] Quantitative assessment of erector spinae muscles in patients with COPD: Novel chest CT-derived index for prognosis. Ann Am Thorac Soc.2016

    • Author(s)
      Tanimura K, Sato S, Fuseya Y, Hasegawa K, Uemasu K, Sato A, Oguma T, Hirai T, Mishima M, Muro S.
    • Journal Title

      Ann Am Thorac Soc

      Volume: 13(3) Issue: 3 Pages: 334-341

    • DOI

      10.1513/annalsats.201507-446oc

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells2016

    • Author(s)
      Konishi S, Gotoh S, Tateishi K, Yamamoto Y, Korogi Y, Matsumoto H, Muro S, Hirai T, Ito I, Tsukita S, Mishima M.
    • Journal Title

      Stem Cell Reports

      Volume: 6 Issue: 1 Pages: 18

    • DOI

      10.1016/j.stemcr.2015.11.010

    • NAID

      120005745633

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of COPD exacerbation frequency with gene expression of pattern recognition receptors in inflammatory cells in induced sputum.2016

    • Author(s)
      Kinose D, Ogawa E, Kudo M, Marumo S, Kiyokawa H, Hoshino Y, Hirai T, Chin K, Muro S, Mishima M.
    • Journal Title

      Clin Respir J.

      Volume: 10(1) Issue: 1 Pages: 11-21

    • DOI

      10.1111/crj.12171

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Emphysema and airway disease affect within-breath changes in respiratory resistance in COPD patients.2015

    • Author(s)
      Hasegawa K, Sato S, Tanimura K, Fuseya Y, Uemasu K, Sato A, Hirai T, Mishima M, Muro S
    • Journal Title

      Respirology

      Volume: - Issue: 5 Pages: 775-81

    • DOI

      10.1111/resp.12535

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia.2015

    • Author(s)
      Tokuda S, Kim YH, Matsumoto H, Muro S, Hirai T, Mishima M, Furuse M.
    • Journal Title

      PLoS One

      Volume: 10(12) Issue: 12 Pages: e0145522-e0145522

    • DOI

      10.1371/journal.pone.0145522

    • NAID

      120005753860

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal shape irregularity of airway lumen assessed by CT in patients with bronchial asthma and COPD.2015

    • Author(s)
      Oguma T, Hirai T, Fukui M, Tanabe N, Marumo S, Nakamura H, Ito H, Sato S, Niimi A, Ito I, Matsumoto
    • Journal Title

      Thorax

      Volume: 70(8) Issue: 8 Pages: 719-24

    • DOI

      10.1136/thoraxjnl-2014-206651

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone mineral density in patients with idiopathic pulmonary fibrosis.2015

    • Author(s)
      Ikezoe K, Handa T, Tanizawa K, Kubo T, Oguma T, Hamada S, Watanabe K, Aihara K, Sokai A, Nakatsuka Y, Muro S, Nagai S, Uno K, Chin K, Fukui M, Hirai T, Mishima M.
    • Journal Title

      Respir Med.

      Volume: 109 Issue: 9 Pages: 1181-1187

    • DOI

      10.1016/j.rmed.2015.06.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis.2015

    • Author(s)
      Sokai A, Handa T, Tanizawa K, Oga T, Uno K, Tsuruyama T, Kubo T, Ikezoe K, Nakatsuka Y, Tanimura K, Muro S, Hirai T, Nagai S, Chin K, Mishima M.
    • Journal Title

      Respir Res.

      Volume: 16 Issue: 1 Pages: 120-120

    • DOI

      10.1186/s12931-015-0280-9

    • NAID

      120005774669

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.2015

    • Author(s)
      146.Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels. Setoh K, Terao C, Muro S, Kawaguchi T, Tabara Y, Takahashi M, Nakayama T, Kosugi S, Sekine A, Yamada R, Mishima M, Matsuda F.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 7754-7754

    • DOI

      10.1038/ncomms8754

    • NAID

      120005743662

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Knee Pain and Low Back Pain Additively Disturb Sleep in the General Population: A Cross-Sectional Analysis of the Nagahama Study.2015

    • Author(s)
      Murase K, Tabara Y, Ito H, Kobayashi M, Takahashi Y, Setoh K, Kawaguchi T, Muro S, Kadotani H, Kosugi S, Sekine A, Yamada R, Nakayama T, Mishima M, Matsuda S, Matsuda F, Chin K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: e0140058-e0140058

    • DOI

      10.1371/journal.pone.0140058

    • NAID

      120005756275

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ピットフォール 若年性肺気腫2015

    • Author(s)
      室 繁郎, 佐藤 晋
    • Journal Title

      呼吸

      Volume: 34(7) Pages: 702-712

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【緊急処置を必要とする呼吸器病態・疾患】慢性閉塞性肺疾患の増悪2015

    • Author(s)
      室 繁郎
    • Journal Title

      呼吸器内科

      Volume: 27(5) Pages: 354-359

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 喘息・COPDにおける気道系・血管系のリモデリングの相違点と類似点 画像的な立場から2015

    • Author(s)
      室 繁郎
    • Journal Title

      日本呼吸器学会誌

      Volume: 4 Pages: 14-14

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Comparison of two devices for respiratory impedance measurement using a forced2014

    • Author(s)
      Tanimura K, Muro S, et al.
    • Journal Title

      J Physiol Sci

      Volume: 64 Pages: 82-377

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of COPD exacerbation frequency with gene2014

    • Author(s)
      Kinose D, Muro S, et al.
    • Journal Title

      Clin Respir J

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] p38 mitogen-activated protein kinase determines the susceptibility to2014

    • Author(s)
      Marumo S, Muro S, et al.
    • Journal Title

      BMC Pulm Med

      Volume: - Pages: 14-79

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] COPD phenotype and treatment.2016

    • Author(s)
      Muro Shigeo
    • Organizer
      1st Asia Oceania Workshop of Pulmonary Functional Imaging and 8th Japanese Society of Pulmonary Function Imaging
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2016-01-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantitative Assessment of Skeletal Muscles Mass in COPD Patients Using Chest CT Images.2015

    • Author(s)
      Tanimura K, Sato S, Sato A, Fuseya Y, Hasegawa K, Uemasu K, Hirai T, Mishima M, Muro S
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 呼吸器疾患とGERD~GERDは気道疾患の悪化因子2014

    • Author(s)
      室 繁郎
    • Organizer
      第66回気管食道科学会
    • Place of Presentation
      高知
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] COPD患者の予後予測因子としての肺動脈径/大動脈径比2014

    • Author(s)
      清川寛文 佐藤晋 新谷亮多 伏屋芳紀 谷村和哉 長谷川浩一 佐藤篤靖 加藤元一 三嶋理晃 室繁郎
    • Organizer
      日本肺高血圧学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-03 – 2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] COPDの併存症と増悪2014

    • Author(s)
      室 繁郎
    • Organizer
      第24回福岡COPD研究会
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] COPDの呼吸機能をめぐる最近の話題 BEYOND FEV12014

    • Author(s)
      室 繁郎
    • Organizer
      第54回臨床呼吸機能講習会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] COPD併存症研究の新展開 ~ 消化器疾患・GERD2014

    • Author(s)
      室 繁郎
    • Organizer
      第88回閉塞性肺疾患研究会ミニシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] COPD~観察研究と薬物治療のup-to-date ~2014

    • Author(s)
      室 繁郎
    • Organizer
      第51回日本呼吸器学会 中国・四国地方会 第21回呼吸器セミナー
    • Place of Presentation
      米子
    • Year and Date
      2014-07-11 – 2014-07-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] COPDと気管支喘息との オーバーラップ症候群2014

    • Author(s)
      室 繁郎
    • Organizer
      第72回日本呼吸器学会・日本結核病学会 九州支部 春季学術講演会
    • Place of Presentation
      福岡
    • Year and Date
      2014-06-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 画像から推察するCOPDの病態2014

    • Author(s)
      室 繁郎
    • Organizer
      第39回吸入療法研究会シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Quantitative Assessment of Chronic Bronchitis Symptoms and Impact of Extrapulmonary Causes in COPD2014

    • Author(s)
      Hasegawa K, Muro S, Sato S, Fuseya Y, Tanimura K, Sato A, Nishioka M, Hirai T, Mishima M
    • Organizer
      American Thoracic Society 2014 International Conference
    • Place of Presentation
      San Diego
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional Assessment Of Emphysematous Lung Of COPD Patients Using Oxygen-Enhanced MRI2014

    • Author(s)
      Yoshinori Fuseya , Shigeo Muro , Aki Kido ,Susumu Sato ,Atsuyasu Sato, Michiyoshi Nishioka, Kazuya Tanimura, Koichi Hasegawa, Toyohiro Hirai, Takeshi Kubo, Koji Fujimoto , , Kyoko Takakura , Hiroshi Kusahara , Naotaka Sakashita, Yoshiharu Ohno , Kaori Togashi , Michiaki Mishima
    • Organizer
      American Thoracic Society 2014 International Conference
    • Place of Presentation
      San Diego
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 重度肺機能障害患者の麻酔を考える:適切なリスク評価と有効な術前介入のために ~COPD~慢性閉塞性肺疾患・肺気腫・慢性気管支炎2014

    • Author(s)
      室 繁郎
    • Organizer
      第61回日本麻酔科学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] COPDにおける慢性気管支炎症状に関連する因子の検討2014

    • Author(s)
      長谷川 浩一 室 繁郎 佐藤 晋 伏屋 芳紀 谷村 和哉 佐藤 篤靖 西岡 慶善 平井 豊博 三嶋 理晃
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] COPDにおけるCT形態評価とOxygen-enhanced MRIによる機能評価の比較2014

    • Author(s)
      伏屋 芳紀, 室 繁郎, 佐藤 篤靖, 佐藤 晋, 平井 豊博, 三嶋 理晃, 富樫 かおり, 久保 武, 木戸 晶, 藤本 晃司, 高倉 京子, 草原 博志, 坂下 尚孝, 大野 良治
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 第54回日本呼吸器学会学術講演会熊谷賞受賞講演 臨床データとモデル動物との比較検討から考察するCOPDの病態解明と治療戦略2014

    • Author(s)
      室 繁郎
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] What we know from the prospective observational study in Kyoto University COPD clinic.2014

    • Author(s)
      室 繁郎
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] COPDにおけるCT形態評価とOxygen-enhanced MRIによる機能評価の比較2014

    • Author(s)
      室 繁郎
    • Organizer
      第6回呼吸機能イメージング研究会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 第53回 日本呼吸器学会学術講演会2013

    • Author(s)
      室 繁郎
    • Organizer
      閉塞性肺疾患の多様性とフェノタイプ「増悪による画像変化」
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Non-smoking COPD In Asia2013

    • Author(s)
      室 繁郎
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Philadelphia
    • Related Report
      2013 Research-status Report
  • [Presentation] The Relationship Between Emphysema Quantified By Computed Tomography And COPD Assessment Test Score2013

    • Author(s)
      伏屋 芳紀
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Philadelphia
    • Related Report
      2013 Research-status Report
  • [Presentation] Developing a Research Protocol - Research Objectives and Research Questions2013

    • Author(s)
      室 繁郎
    • Organizer
      Ho Chi Minh Society of Respirology
    • Place of Presentation
      Ho Chi Minh City
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] COPD診療における呼吸機能とCT画像の役割2013

    • Author(s)
      室 繁郎
    • Organizer
      第60回 日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Role of CT in COPD Phenotyping2013

    • Author(s)
      室 繁郎
    • Organizer
      第18回 アジア太平洋呼吸器学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] COPDと喘息治療のポイント2013

    • Author(s)
      室 繁郎
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] COPD治療におけるICS/LABAの位置づけ2013

    • Author(s)
      室 繁郎
    • Organizer
      第63回 日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] 臨床病理2014

    • Author(s)
      室 繁郎
    • Total Pages
      5
    • Publisher
      呼吸器疾患診療を支える臨床検査 COPD診療における呼吸機能とCT画像の役割
    • Related Report
      2014 Research-status Report
  • [Book] 成人病と生活習慣病2014

    • Author(s)
      佐藤 晋, 室 繁郎
    • Total Pages
      5
    • Publisher
      【全身成人病としてのCOPD】 COPDの呼吸機能
    • Related Report
      2014 Research-status Report
  • [Book] 日本胸部臨床2014

    • Author(s)
      佐藤 晋, 室 繁郎, 三嶋 理晃
    • Total Pages
      9
    • Publisher
      【高齢者の呼吸器疾患-若年・高齢者発症との違い-】 COPD 若年発症COPDと高齢者COPDについて
    • Related Report
      2014 Research-status Report
  • [Book] 呼吸と循環2014

    • Author(s)
      佐藤 晋, 室 繁郎
    • Total Pages
      6
    • Publisher
      【疾患と運動時低酸素血症】 COPDと運動時低酸素血症
    • Related Report
      2014 Research-status Report
  • [Book] 日本呼吸器学会誌2014

    • Author(s)
      室 繁郎
    • Total Pages
      7
    • Publisher
      【COPDの最新情報】 (Topics 5)併存症・合併症のインパクトとその対策
    • Related Report
      2014 Research-status Report
  • [Book] THE LUNG-perspectives2014

    • Author(s)
      佐藤 篤靖, 室 繁郎
    • Total Pages
      3
    • Publisher
      【COPDを改めて問う】 COPDにおける併存症 気流閉塞、肺気腫いずれに関与しているのか
    • Related Report
      2014 Research-status Report
  • [Book] 薬事2014

    • Author(s)
      室 繁郎
    • Total Pages
      5
    • Publisher
      【喘息・COPD患者への吸入指導】 COPDの診断と治療 ガイドラインをふまえて
    • Related Report
      2014 Research-status Report
  • [Book] 内科2014

    • Author(s)
      室 繁郎
    • Total Pages
      8
    • Publisher
      【COPD治療の新時代 21世紀の「社会的」生活習慣病】 COPDの早期診断,治療の枠組み,急性増悪の対応 新薬乱立の前に知っておくべきこと
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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