Possible mechanism of parenchymal destruction on the analogy of image analysis
| Project/Area Number |
25461156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
Shigeo Muro 京都大学, 医学(系)研究科(研究院), 講師 (60344454)
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| Co-Investigator(Kenkyū-buntansha) |
SATO ATSUYASU 京都大学, 医学研究科, 特定病院助教 (30706677)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA TOMOYUKI 関西医科大学, 医学研究科, 教授 (20362527)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 呼吸器内科 / 肺気腫 / 細胞外マトリクス / 炎症 / 画像解析 / 臨床呼吸器学 / COPD / 再生医療 / 気道炎症 / 細胞外マトリックス / 免疫 / 慢性閉塞性肺疾患 |
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| Outline of Final Research Achievements |
In our COPD prospective observational clinical study, we recruited 82 COPD subjects. Preliminary analysis showed that humoral immunity influence the frequency of COPD exacerbations. The observation period will complete at the end of June 2016, and we will finalize the data and analyze the final data. At the same time, we established the model mouse of the pulmonary emphysema by giving a small amount of proteolytic enzyme in the respiratory tract. We tried to prevent emphysema development by adding elastic fiber synthetic related protein in the lung, however, we could not find strong evidence that our method could prevent emphysema in the whole lung. However, the pathology showed that some destroyed lung field were repaired by new lung cells. We will continue to study this repair process and try to establish new regenerative method in COPD treatment.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells.2016
Author(s)
Konishi S, Gotoh S, Tateishi K, Yamamoto Y, Korogi Y, Matsumoto H, Muro S, Hirai T, Ito I, Tsukita S, Mishima M.
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Journal Title
Stem Cell Reports
Volume: 6
Issue: 1
Pages: 18-25
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Longitudinal shape irregularity of airway lumen assessed by CT in patients with bronchial asthma and COPD.2015
Author(s)
Oguma T, Hirai T, Fukui M, Tanabe N, Marumo S, Nakamura H, Ito H, Sato S, Niimi A, Ito I, Matsumoto
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Journal Title
Thorax
Volume: 70(8)
Issue: 8
Pages: 719-24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bone mineral density in patients with idiopathic pulmonary fibrosis.2015
Author(s)
Ikezoe K, Handa T, Tanizawa K, Kubo T, Oguma T, Hamada S, Watanabe K, Aihara K, Sokai A, Nakatsuka Y, Muro S, Nagai S, Uno K, Chin K, Fukui M, Hirai T, Mishima M.
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Journal Title
Respir Med.
Volume: 109
Issue: 9
Pages: 1181-1187
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis.2015
Author(s)
Sokai A, Handa T, Tanizawa K, Oga T, Uno K, Tsuruyama T, Kubo T, Ikezoe K, Nakatsuka Y, Tanimura K, Muro S, Hirai T, Nagai S, Chin K, Mishima M.
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Journal Title
Respir Res.
Volume: 16
Issue: 1
Pages: 120-120
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.2015
Author(s)
146.Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels. Setoh K, Terao C, Muro S, Kawaguchi T, Tabara Y, Takahashi M, Nakayama T, Kosugi S, Sekine A, Yamada R, Mishima M, Matsuda F.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 7754-7754
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Knee Pain and Low Back Pain Additively Disturb Sleep in the General Population: A Cross-Sectional Analysis of the Nagahama Study.2015
Author(s)
Murase K, Tabara Y, Ito H, Kobayashi M, Takahashi Y, Setoh K, Kawaguchi T, Muro S, Kadotani H, Kosugi S, Sekine A, Yamada R, Nakayama T, Mishima M, Matsuda S, Matsuda F, Chin K.
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Journal Title
PLoS One
Volume: 10
Issue: 10
Pages: e0140058-e0140058
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Quantitative Assessment of Skeletal Muscles Mass in COPD Patients Using Chest CT Images.2015
Author(s)
Tanimura K, Sato S, Sato A, Fuseya Y, Hasegawa K, Uemasu K, Hirai T, Mishima M, Muro S
Organizer
American Thoracic Society
Place of Presentation
Denver, Colorado, USA
Year and Date
2015-05-13
Related Report
Int'l Joint Research
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[Presentation] Functional Assessment Of Emphysematous Lung Of COPD Patients Using Oxygen-Enhanced MRI2014
Author(s)
Yoshinori Fuseya , Shigeo Muro , Aki Kido ,Susumu Sato ,Atsuyasu Sato, Michiyoshi Nishioka, Kazuya Tanimura, Koichi Hasegawa, Toyohiro Hirai, Takeshi Kubo, Koji Fujimoto , , Kyoko Takakura , Hiroshi Kusahara , Naotaka Sakashita, Yoshiharu Ohno , Kaori Togashi , Michiaki Mishima
Organizer
American Thoracic Society 2014 International Conference
Place of Presentation
San Diego
Year and Date
2014-05-16 – 2014-05-21
Related Report
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[Presentation] COPDにおけるCT形態評価とOxygen-enhanced MRIによる機能評価の比較2014
Author(s)
伏屋 芳紀, 室 繁郎, 佐藤 篤靖, 佐藤 晋, 平井 豊博, 三嶋 理晃, 富樫 かおり, 久保 武, 木戸 晶, 藤本 晃司, 高倉 京子, 草原 博志, 坂下 尚孝, 大野 良治
Organizer
第54回日本呼吸器学会学術講演会
Place of Presentation
大阪
Year and Date
2014-04-25 – 2014-04-27
Related Report
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