| Project/Area Number |
25461159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shimane University |
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Principal Investigator |
SANO Chiaki 島根大学, 医学部, 准教授 (70325059)
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| Co-Investigator(Kenkyū-buntansha) |
多田納 豊 島根大学, 医学部, 助教 (70432614)
礒部 威 島根大学, 医学部, 教授 (70284198)
金廣 優一 島根大学, 医学部, 助教 (60609197)
三浦 聖高 島根大学, 医学部, 助教 (90646986)
冨岡 治明 安田女子大学, 教育学部, 教授 (40034045)
吉山 裕規 島根大学, 医学部, 教授 (10253147)
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| Research Collaborator |
TANINO Ryosuke 島根大学, 医学部, 研究員
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 非結核性抗酸菌 / 漢方薬 / 免疫補助療法 / マウスモデル / ジェノタイプ / 感染実験 / 化学療法 |
|---|
| Outline of Final Research Achievements |
Nontuberculosis mycobacterial infections are characterized by the ineffectiveness of antimycobacterial drugs. The disease results in immuno-suppression and infection with dormant types of mycobacteria and, to date, available chemotherapy regimens are limited. The aim of this study was to investigate useful traditional Chinese medicines for adjunctive chemotherapy against refractory mycobacteriosis. First, we investigated whether the drug susceptibility profile of the Mycobacterium avium complex (MAC) is associated with the genotype. Next, we established a human nodular bronchiectatic MAC lung disease model by novel intrapulmonary injection techniques. The oral administration of “Mao-To” decreased the expression of Th2-related cytokines in novel mouse models.
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