Proteomic analysis and genotyping of nontuberculosis mycobacteria to investigate effects of traditional Chinese medicines against pathogenesis
Project/Area Number |
25461159
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Shimane University |
Principal Investigator |
SANO Chiaki 島根大学, 医学部, 准教授 (70325059)
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Co-Investigator(Kenkyū-buntansha) |
多田納 豊 島根大学, 医学部, 助教 (70432614)
礒部 威 島根大学, 医学部, 教授 (70284198)
金廣 優一 島根大学, 医学部, 助教 (60609197)
三浦 聖高 島根大学, 医学部, 助教 (90646986)
冨岡 治明 安田女子大学, 教育学部, 教授 (40034045)
吉山 裕規 島根大学, 医学部, 教授 (10253147)
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Research Collaborator |
TANINO Ryosuke 島根大学, 医学部, 研究員
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 非結核性抗酸菌 / 漢方薬 / 免疫補助療法 / マウスモデル / ジェノタイプ / 感染実験 / 化学療法 |
Outline of Final Research Achievements |
Nontuberculosis mycobacterial infections are characterized by the ineffectiveness of antimycobacterial drugs. The disease results in immuno-suppression and infection with dormant types of mycobacteria and, to date, available chemotherapy regimens are limited. The aim of this study was to investigate useful traditional Chinese medicines for adjunctive chemotherapy against refractory mycobacteriosis. First, we investigated whether the drug susceptibility profile of the Mycobacterium avium complex (MAC) is associated with the genotype. Next, we established a human nodular bronchiectatic MAC lung disease model by novel intrapulmonary injection techniques. The oral administration of “Mao-To” decreased the expression of Th2-related cytokines in novel mouse models.
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] 1)Extrapulmonary tuberculosis mimicking Mendelian susceptibility to mycobacterial disease in a patient with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation2016
Author(s)
Kataoka S, Muramatsu H, Okuno Y, Hayashi Y, Mizoguchi Y, Tsumura M, Okada S, Kobayashi M, Sano C, Sato H, Oh-Iwa I, Ito M, Kojima D Hama A, Takahashi Y, Kojima S
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Journal Title
J Allergy Clin Immunol
Volume: 137
Issue: 2
Pages: 619-622
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Nephrotoxicity induced by piperacillin-tazobactam in late elderly Japanese patients with nursing and healthcare associated pneumonia2014
Author(s)
Karino F, Nishimura N, Ishihara N, Moriyama H, Miura K, Hamaguchi S, Sutani A, Kuraki T, Ikawa K, Morikawa N, Naora K, Isobe T
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Journal Title
Biol Pharm Bull
Volume: 37
Pages: 1971-1976
NAID
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of piperacillin/tazobactam versus biapenem in late elderly patients with nursing- and healthcare-associated pneumonia2013
Author(s)
Karino F, Miura K, Fuchita H, Koba N, Nishikawa E, Hotta T, Okimoto T, Iwamoto S, Tsubata Y, Tada M, Hamaguchi S, Honda T, Ohe M, Sutani A, Kuraki T, Takeyama H, Isobe T
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Journal Title
J Infect Chemother
Volume: 19
Issue: 5
Pages: 909-915
DOI
Related Report
Peer Reviewed
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[Presentation] Establishment of the Novel Mouse Models of Human Lung Nontuberculous Mycobacterial Infections2016
Author(s)
T. Isobe, C. Sano, R.Tanino, Y. Tatano, Y. Mori, M. Nakao,Y. Amano, T. Hotta, M. Hamaguchi, T. Okimoto,Y. Tsubata, S. Hamaguchi, H. Takeyama
Organizer
American Thoracic Society 2016 International Conference
Place of Presentation
The Moscone Center,San Francisco USA
Related Report
Int'l Joint Research
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[Presentation] Comparison Of Clinical And Radiographic Characteristics Between Nontuberculous Mycobacterial Lung Disease And Pulmonary Tuberculosis2014
Author(s)
K. Miura, N. Koba, T. Hotta, R. Tanino, M. Hamaguchi, T. Okimoto, Y. Tsubata, S. Hamaguchi, M. Ohe, A. Sutani, H. Takeyama, Y. Awaya, H. Moriyama, M. Hirose, T. Kuraki, T. Isobe
Organizer
ATS 2014 international conference
Place of Presentation
San Diego Convention Center, USA
Year and Date
2014-05-16 – 2014-05-21
Related Report
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