| Project/Area Number |
25461166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Masaru 北里大学, 医学部, 准教授 (00234500)
FUJII Shigemoto 東北大学, 医学系研究科, 准教授 (00325333)
AKAIKE Takaaki 東北大学, 医学系研究科, 教授 (20231798)
KOKUBO Kenichi 北里大学, 医療衛生部, 准教授 (20287965)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 水素ガス / 一酸化窒素ガス / 吸入療法 / ARDS |
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| Outline of Final Research Achievements |
The objective of the present study was to clarify the effects of inhalation of either nitric oxide (NO) or hydrogen gas, or simultaneous inhalation of both gases for a mouse model of lethal septic shock due to severe lung injury.
NO gas inhalation provide beneficial effect such as inhibitions of neutrophil infiltration and vascular permeability increase, but adverse effect such as interleukin-6 (proinflammatory cytokine) increase, and resulted in the no change in the survival. On the other hand, hydrogen gas inhalation cannot inhibit neutrophil infiltration but inhibit vascular permeability increase and did not change interleukin-6 level, and resulted in the improved survival. Simultaneous inhalation of both gases will be a good strategy to reduce adverse effects of NO without eliminating the beneficial effects of NO.
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