| Project/Area Number |
25461167
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 気管支喘息 / 補助シグナル分子 / 自然リンパ球 / バイオマーカー / Th2 / CD27 / ペリオスチン / テネイシンC |
|---|
| Outline of Final Research Achievements |
We have repoted an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation. Moreover, not only Th2 cells but also a variety of innate subsets of lymphoid cells such as innate lymphoid cells (ILCs), and mucosal-associated invariant T (MAIT) cells are involved in asthma and may have important effector functions in asthmatics. In the present study, we investigated whether the CD27-CD4+T cells ILCs and MAIT cells in the peripheral blood of patients with asthma would be associated with clinical asthma parameters. There were no significant differences in the frequencies of CD27-CD4+T cells, ILCs and MAIT cells between the asthma severity groups. The percentage of activated NK cells, group 1 ILCs, group 2 ILCs, group 3 ILCs and MAIT cells in the peripheral blood of asthmatics were positively correlated with each other, and may orchestrate immune responses, but not behave as an individual population, in asthmatic airway inflammation.
|
