| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Chronic obstructive pulmonary disease (COPD) is associated with cachexia and comorbidities that have a significant impact on its prognosis. We explored the role of subcutaneous adipose tissue for new approach to cachexia and comorbidities in COPD, particularly pulmonary emphysema. We identified reduced fat tissue angiogenesis as the mechanism of wasting of subcutaneous adipose tissue in a mouse model with pulmonary emphysema. Wasting of subcutaneous adipose tissue leads to ectopic fat accumulation in visceral adipose tissue and impaired glucose homeostasis due to the lower capacity for storage of surplus energy. A stimulator of angiogenesis improved fat tissue angiogenesis and restored the capacity of subcutaneous adipose tissue, and consequently improved both ectopic fat accumulation and impaired glucose homeostasis. Targeting the vascular component of adipose tissue by modulation of angiogenesis may be developed as a useful therapeutic intervention in cachexic emphysema patients.
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