| Project/Area Number |
25461174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Kida Kozui 日本医科大学, 医学部, 教授 (90142645)
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| Co-Investigator(Kenkyū-buntansha) |
Arai Tomio 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019)
Betsuyaku Tomoko 慶應義塾大学, 医学部(信濃町), 教授 (60333605)
Ishii Takeo 日本医科大学, 医学部, 講師 (90445750)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性閉塞性肺疾患 / 遺伝子多型 / ECM / マルファン症候群 / 肺気腫 / Marfan症候群 / 細胞外基質 (ECM) / TGF-beta / アンギオテンシン / LTBP4 / 動脈瘤 |
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| Outline of Final Research Achievements |
COPD with thracic aneurysm is similar to Marfan syndrome from the clinical point of view, and both diseases could have a common pathogenesis through extracellular (ECM) malformation. Thus, we hypothesized that ECM-related genes have critical roles in pathogenesis of emphysema and their genetic variations (single nucleotide polymorphisms (SNPs)) are associated with emphysema severity in human.Two populations were studied: population A comprised 574 smokers including 352 COPD , and population B comprised 329 smokers including 258 COPD . In population A. A G allele at SNP rs1051303 (one of the coding SNPs of LTBP4) was positively correlated with the low-attenuation area (LAA%) in the upper lung (p = 0.029) in population A, and this relationship was validated in population B in one-sided test (p = 0.038). LTBP4 might have a critical role in pathogenesis of emphysema in human. The pathogenetic mechanism related to LTBP4 remains to be elucidated.
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