| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
I examined the involvement of the function of the lungs and oxidative stress defense protein DJ-1 respiratory disease onset. Using human lung epithelial cell-derived A549, to establish a DJ-1 protein knockdown cell line. As a result, the knockdown cell lines, became more vulnerable to oxidative stress. Then, the gene whose expression is varied among A549 cells and knockdown cell lines were screened by DNA micro array. As a result, gene expression of some transporters were varied. The transporter involved in respiratory disease onset have been reported. The transporter and DJ-1 are co-localization is revealed from confocal microscopy. Coordinated action of DJ-1 protein and the transporter was suggested.
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