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RNAi for the treatment of refractory pulmonary diseases

Research Project

Project/Area Number 25461189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionMie University

Principal Investigator

Kobayashi Tetsu  三重大学, 医学部附属病院, 准教授 (20437114)

Co-Investigator(Kenkyū-buntansha) GABAZZA ESTEBAN  三重大学, 医学系研究科, 教授 (00293770)
TAGUCHI OSAMU  三重大学, 保健管理センター, 教授 (90197244)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordssiRNA / RNAi / TGF / 肺線維症 / TGF-β
Outline of Final Research Achievements

The nucleic acid innovative drug development is expected as a new therapeutic method for the refractory disease.We make the original nucleic acid as Japan original and aim at the innovative drug development to respiratory disease with the administration of the trans-airway.As a result of designing a nucleic acid using a mouse disease model, and having tested it, control of the disease clinical condition was found to be possible by a trans-airway nucleic acid medication.These results suggest that intra-tracheal instillation of RNAi agents may be useful for the therapy of pulmonary diseases.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013 Other

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] irculating fibrocytes correlate with the asthma control test score.2016

    • Author(s)
      Kobayashi H, Naito M, Masuya M, Maruyama M, Urata K, Takahashi Y, Tomaru A,Fujiwara K, Ohnishi M, Takagi T, Kobayashi T,D'Alessandro-Gabazza C, Urawa M,Gabazza EC, Taguchi O, Takei Y.
    • Journal Title

      Allergol Immunopathol (Madr).

      Volume: 44 Issue: 3 Pages: 152-154

    • DOI

      10.1016/j.aller.2015.09.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Activated protein C modulates the proinflammatory activity of dendritic cells.2015

    • Author(s)
      Matsumoto T, Matsushima Y, Toda M, Roeen Z, D'Alessandro-Gabazza CN, Hinneh JA, Harada E, Yasuma T, Yano Y, Urawa M, Kobayashi T, Taguchi O, Gabazza EC.
    • Journal Title

      J Asthma Allergy

      Volume: 8 Pages: 29-37

    • DOI

      10.2147/jaa.s75261

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Thrombomodulin inhibits the activation of eosinophils and mast cells.2015

    • Author(s)
      Roeen Z, Toda M, D'Alessandro-Gabazza CN, Onishi M, Kobayashi T, Yasuma T, Urawa M, Taguchi O, Gabazza EC.
    • Journal Title

      Cell Immunol.

      Volume: 293 Issue: 1 Pages: 34-40

    • DOI

      10.1016/j.cellimm.2014.11.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels.2014

    • Author(s)
      Kobayashi T, Kim H, Liu X, Sugiura H, Kohyama T, Fang Q, Wen FQ, Abe S, Wang X, Atkinson JJ, Shipley JM, Senior RM, Rennard SI.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol.

      Volume: 306(11) Issue: 11 Pages: 1006-1015

    • DOI

      10.1152/ajplung.00015.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of18O-labeled RNA for application to kinetic studies and imaging.2013

    • Author(s)
      Hamasaki T, Matsumoto T, Sakamoto N, Shimahara A, Kato S, Yoshitake A, Utsunomiya A, Yurimoto H, Gabazza EC, Ohgi T.
    • Journal Title

      Nucleic Acids Res.

      Volume: 41 Issue: 12 Pages: e126-e126

    • DOI

      10.1093/nar/gkt344

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system.2013

    • Author(s)
      Naito M, Taguchi O, Kobayashi T, Takagi T, D'Alessandro-Gabazza CN, Matsushima Y, Boveda-Ruiz D, Gil-Bernabe P, Matsumoto T, Chelakkot-Govindalayathil AL, Toda M, Yasukawa A, Hataji O, Morser J, Takei Y, Gabazza EC.
    • Journal Title

      Am J Respir Cell Mol Biol.

      Volume: 49 Issue: 4 Pages: 646-653

    • DOI

      10.1165/rcmb.2012-0454oc

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] RNA新時代2015

    • Author(s)
      小林 哲
    • Organizer
      第12回呼吸器バイオマーカー研究会
    • Place of Presentation
      東京(大手町サンケイプラザ)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 気道リモデリングとその制御方法の試み2015

    • Author(s)
      小林 哲
    • Organizer
      第四回神奈川気道炎症病態研究会
    • Place of Presentation
      神奈川県横浜市(ベイシェラトンホテル)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] IPFに対するRNAi創薬の可能性2015

    • Author(s)
      小林 哲
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      東京(国際フォーラム)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マウス疾患モデルを用いた線維化マーカーの探索2014

    • Author(s)
      小林 哲
    • Organizer
      第11回呼吸器バイオマーカー研究会
    • Place of Presentation
      東京、都市センターホテル
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺線維化マウスを用いた細菌叢の検討2014

    • Author(s)
      小林哲
    • Organizer
      第17回間質性肺炎細胞分子病態研究会
    • Place of Presentation
      東京、砂防会館別館
    • Year and Date
      2014-08-23
    • Related Report
      2014 Research-status Report
  • [Presentation] RNA interference for the treatment of intractable pulmonary diseases2013

    • Author(s)
      Tetsu Kobayashi
    • Organizer
      American Thracic Society international conference 2013
    • Place of Presentation
      Philadelphia
    • Related Report
      2013 Research-status Report
  • [Presentation] 呼吸器疾患におけるRNAiを用いた創薬の可能性

    • Author(s)
      小林 哲
    • Organizer
      第16回間質性肺炎細胞分子病態研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 呼吸器疾患におけるRNAiを用いた治療開発の可能性

    • Author(s)
      小林 哲
    • Organizer
      第53回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] Annual Review 2016 呼吸器2016

    • Author(s)
      小林 哲、ガバザ エステバン
    • Total Pages
      6
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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