Role and significance for therapy of microparticles in inflammatory lung disease
| Project/Area Number |
25461193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Okayama Akihiko 宮崎大学, 医学部, 教授 (70204047)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | マイクロパーティクル / 炎症性肺疾患 / 間質性肺炎 / サルコイドーシス / 情報伝達物質 / A549細胞 |
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| Outline of Final Research Achievements |
We investigated whether microparticle（MP）can be one of the clinical markers for inflammatory lung diseases (ILD). MP was detectable in bronchoalveolar lavage fluid by FACS and its concentration was correlated with number of white blood cells, but not with serum markers such as CRP, LDH and KL-6. The patients with ILD who eventually died did not show high MP. When a cell line (A549) was induced to apoptosis or activated state, MP concentration in the supernatant was increased. These data suggested that MP may have certain significance in ILD, but still not be available as a clinical marker.
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Report
(4 results)
Research Products
(5 results)
