| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
TMEM16A has been recently discovered as Ca-activated Cl channel and regulates airway secretion and smooth muscle contraction in asthma. In this study, we showed that TMEM16A inhibitors inhibited the increases in Cl ion transport induced by antigen challenge and Ca-dependent agonist in an asthma model, and that TMEM16A was localized at apical membrane and around mucus in goblet cells. Furthermore, we showed that clarithromycin inhibited TMEM16A in IL-13-induced cultured goblet cell metaplasia. These data suggest that TMEM16A is a new target for the therapy of airway hypersecretory diseases.
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