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(Pro)renin receptor in renal and cardiovascular injuries.

Research Project

Project/Area Number 25461205
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionTohoku University

Principal Investigator

TOTSUNE Kazuhito  東北大学, 薬学研究科(研究院), 客員教授 (10217515)

Co-Investigator(Kenkyū-buntansha) TAKAHASI Kazuhiro  東北大学, 大学院医学系研究科, 教授 (80241628)
IMAI Yutaka  東北大学, 大学院薬学研究科, 教授 (40133946)
Co-Investigator(Renkei-kenkyūsha) HIROSE Takuo  東北大学, 大学院医学系研究科, 非常勤講師 (20599302)
TAKAHASI Nobuyuki  東北大学, 大学院薬学研究科, 准教授 (40588456)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords遺伝子 / 循環器・高血圧 / 生理活性 / 発現・制御 / 腎障害 / プロレニン受容体 / 悪性腫瘍 / 脳萎縮
Outline of Final Research Achievements

Pathophysiological roles of (pro)renin receptor ((P)RR) were investigated in renal and cardiovascular injuries and cancers. This research project revealed that (1) soluble type (P)RR (sPRR) is present in human plasma and sPRR levels were elevated in patients with primary aldosteronism and Gittelman syndrome, (2) high sodium intake or dehydration induced (P)RR expression in rat kidneys, (3) (P)RR was associated with cancer proliferation, and (4) sPRR levels have an association with brain atrophy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (8 results)

  • [Journal Article] Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide2015

    • Author(s)
      Hosaka M, Metoki H, Satoh M, Ohkubo T, Asayama K, Kikuya M, Inoue R, Obara T, Hirose T, Imai Y on behalf of The J-HOME-CARD Study group.
    • Journal Title

      HYPERTENSION RESEARCH

      Volume: 38 Issue: 10 Pages: 701

    • DOI

      10.1038/hr.2015.64

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: The Ohasama study2015

    • Author(s)
      Satoh M, Hosaka M, Asayama K, Kikuya M, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Totsune K, Hoshi H, Mano N, Node K, Imai Y, Ohkubo T.
    • Journal Title

      Journal of Hypertension

      Volume: 33 Issue: 8 Pages: 1536

    • DOI

      10.1097/hjh.0000000000000570

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A functional (pro)renin receptor is expressed in human lymphocytes and monocytes.2015

    • Author(s)
      Narumi K, Hirose T, Sato E, Mori T, Kisu K, Ishikawa M, Totsune K, Ishii T, Ichihara A, Nguyen G, Sato H, Ito S.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 308 Issue: 5 Pages: F487-F499

    • DOI

      10.1152/ajprenal.00206.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron.2015

    • Author(s)
      Rong R, Ito O, Mori N, Muroya Y, Tamura Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M.
    • Journal Title

      Peptides.

      Volume: 63 Pages: 156-62

    • DOI

      10.1016/j.peptides.2014.12.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma.2015

    • Author(s)
      Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, Kitada K, Nakano D, Kobori H, Kohno M, Masaki T, Suzuki Y, Yachida S, Nishiyama A.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 8854-8854

    • DOI

      10.1038/srep08854

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity.2014

    • Author(s)
      Nguyen G, Blanchard A, Curis E, Bergerot D, Chambon Y, Hirose T, Caumont-Prim A, Tabard SB, Baron S, Frank M, Totsune K, Azizi M.
    • Journal Title

      Hypertension

      Volume: 63 Issue: 2 Pages: 297-302

    • DOI

      10.1161/hypertensionaha.113.02217

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased expression of (pro)renin receptor in aldosterone-producing adenomas2013

    • Author(s)
      Yamamoto H, Kaneko K, Ohba K, Morimoto R, Hirose T, Satoh F, Totsune K, Takahashi K
    • Journal Title

      Peptides

      Volume: 49 Pages: 68-73

    • DOI

      10.1016/j.peptides.2013.08.022

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] インスリンの(プロ)レニン受容体を介した乳癌の細胞増殖機構の解明2016

    • Author(s)
      山村 直、大場浩史、田島一基、戸恒和人、上月正博、高橋和広
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2016-04-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dahl食塩感受性ラットの腎における高食塩摂取によるプロレニン受容体発現の増加2016

    • Author(s)
      山越聖子、伊藤 修、戎 栄、大崎雄介、森 建文、伊藤貞嘉、高橋和広、戸恒和人、上月正博
    • Organizer
      第20回特定非営利活動法人東北内分泌研究会、第32回日本内分泌学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 睡眠時無呼吸症候群における血中可溶性(プロ)レニン受容体濃度は重症度に相関する。2015

    • Author(s)
      田島 一基、大場浩史、山村 直、西島 嗣生、櫻井 滋、戸恒和人、高橋和広
    • Organizer
      第42回日本神経内分泌学会 第23回日本行動神経内分泌研究会 合同学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 睡眠時無呼吸症候群における血中可溶性(プロ)レニン受容体の検討: 重症度との相関2014

    • Author(s)
      田島一基、西島嗣生、櫻井滋、大場浩史、金子桐子、戸恒和人、高橋和広
    • Organizer
      第18回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト腎臓および副腎における(プロ)レニン受容体の発現の検討2014

    • Author(s)
      山本 肇、金子桐子、大場浩史、森本玲、廣瀬卓男、佐藤文俊、戸恒和人、高橋和広
    • Organizer
      第54回 日本臨床化学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-05 – 2014-09-07
    • Related Report
      2014 Research-status Report
  • [Presentation] アルドステロン産生副腎皮質腺腫における(プロ)レニン受容体の発現増加2014

    • Author(s)
      高橋和広、山本肇、金子桐子、大場浩史、森本玲、佐藤文俊、戸恒和人
    • Organizer
      第111回日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト血中プロレニン受容体様免疫活性物質の検討2013

    • Author(s)
      戸恒和人、廣瀬卓男、藤原正子、関野宏、佐藤博、高橋和広、今井潤
    • Organizer
      第17回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] レニン・アンジオテンシン系の新規因子、プロレニン受容体の乳癌における発現と腫瘍病態への関与の検討2013

    • Author(s)
      大場浩史、西山浩史、金子桐子、廣瀬卓男、戸恒和人、笹野公伸、鈴木貴、高橋和広
    • Organizer
      第17回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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