(Pro)renin receptor in renal and cardiovascular injuries.

• Project/Area Number: 25461205
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: TOTSUNE Kazuhito 東北大学, 薬学研究科(研究院), 客員教授 (10217515)
• Co-Investigator(Kenkyū-buntansha): TAKAHASI Kazuhiro 東北大学, 大学院医学系研究科, 教授 (80241628) ; IMAI Yutaka 東北大学, 大学院薬学研究科, 教授 (40133946)
• Co-Investigator(Renkei-kenkyūsha): HIROSE Takuo 東北大学, 大学院医学系研究科, 非常勤講師 (20599302) ; TAKAHASI Nobuyuki 東北大学, 大学院薬学研究科, 准教授 (40588456)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 遺伝子 / 循環器・高血圧 / 生理活性 / 発現・制御 / 腎障害 / プロレニン受容体 / 悪性腫瘍 / 脳萎縮

Outline of Final Research Achievements

Pathophysiological roles of (pro)renin receptor ((P)RR) were investigated in renal and cardiovascular injuries and cancers. This research project revealed that (1) soluble type (P)RR (sPRR) is present in human plasma and sPRR levels were elevated in patients with primary aldosteronism and Gittelman syndrome, (2) high sodium intake or dehydration induced (P)RR expression in rat kidneys, (3) (P)RR was associated with cancer proliferation, and (4) sPRR levels have an association with brain atrophy.

Research Products

• [Journal Article] Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide. (2015)
  • Author(s): Hosaka M, Metoki H, Satoh M, Ohkubo T, Asayama K, Kikuya M, Inoue R, Obara T, Hirose T, Imai Y on behalf of The J-HOME-CARD Study group.
  • Journal Title: HYPERTENSION RESEARCH Volume: 38 Issue: 10 Pages: 701-707
  • DOI: 10.1038/hr.2015.64
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between N-terminal pro BNP and day-to-day blood pressure and heart rate variability in a general population: The Ohasama Study. (2015)
  • Author(s): Satoh M, Hosaka M, Asayama K, Kikuya M, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Totsune K, Hoshi H, Mano N, Node K, Imai Y, Ohkubo T.
  • Journal Title: Journal of Hypertension Volume: - Issue: 8 Pages: 1536-1541
  • DOI: 10.1097/hjh.0000000000000570
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A functional (pro)renin receptor is expressed in human lymphocytes and monocytes. (2015)
  • Author(s): Narumi K, Hirose T, Sato E, Mori T, Kisu K, Ishikawa M, Totsune K, Ishii T, Ichihara A, Nguyen G, Sato H, Ito S.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 308 Issue: 5 Pages: F487-F499
  • DOI: 10.1152/ajprenal.00206.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron. (2015)
  • Author(s): Rong R, Ito O, Mori N, Muroya Y, Tamura Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M.
  • Journal Title: Peptides. Volume: 63 Pages: 156-62
  • DOI: 10.1016/j.peptides.2014.12.007
  • Peer Reviewed / Open Access
• [Journal Article] (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma. (2015)
  • Author(s): Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, Kitada K, Nakano D, Kobori H, Kohno M, Masaki T, Suzuki Y, Yachida S, Nishiyama A.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 8854-8854
  • DOI: 10.1038/srep08854
  • Peer Reviewed / Open Access
• [Journal Article] Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity. (2014)
  • Author(s): Nguyen G, Blanchard A, Curis E, Bergerot D, Chambon Y, Hirose T, Caumont-Prim A, Tabard SB, Baron S, Frank M, Totsune K, Azizi M.
  • Journal Title: Hypertension Volume: 63 Issue: 2 Pages: 297-302
  • DOI: 10.1161/hypertensionaha.113.02217
  • Peer Reviewed
• [Journal Article] Increased expression of (pro)renin receptor in aldosterone-producing adenomas (2013)
  • Author(s): Yamamoto H, Kaneko K, Ohba K, Morimoto R, Hirose T, Satoh F, Totsune K, Takahashi K
  • Journal Title: Peptides Volume: 49 Pages: 68-73
  • DOI: 10.1016/j.peptides.2013.08.022
  • Peer Reviewed
• [Presentation] インスリンの(プロ)レニン受容体を介した乳癌の細胞増殖機構の解明 (2016)
  • Author(s): 山村 直、大場浩史、田島一基、戸恒和人、上月正博、高橋和広
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2016-04-21
• [Presentation] Dahl食塩感受性ラットの腎における高食塩摂取によるプロレニン受容体発現の増加 (2016)
  • Author(s): 山越聖子、伊藤 修、戎 栄、大崎雄介、森 建文、伊藤貞嘉、高橋和広、戸恒和人、上月正博
  • Organizer: 第20回特定非営利活動法人東北内分泌研究会、第32回日本内分泌学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-09
• [Presentation] 睡眠時無呼吸症候群における血中可溶性（プロ）レニン受容体濃度は重症度に相関する。 (2015)
  • Author(s): 田島 一基、大場浩史、山村 直、西島 嗣生、櫻井 滋、戸恒和人、高橋和広
  • Organizer: 第42回日本神経内分泌学会 第23回日本行動神経内分泌研究会 合同学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2015-09-18
• [Presentation] 睡眠時無呼吸症候群における血中可溶性(プロ)レニン受容体の検討: 重症度との相関 (2014)
  • Author(s): 田島一基、西島嗣生、櫻井滋、大場浩史、金子桐子、戸恒和人、高橋和広
  • Organizer: 第18回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] ヒト腎臓および副腎における(プロ)レニン受容体の発現の検討 (2014)
  • Author(s): 山本 肇、金子桐子、大場浩史、森本玲、廣瀬卓男、佐藤文俊、戸恒和人、高橋和広
  • Organizer: 第54回 日本臨床化学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-05 – 2014-09-07
• [Presentation] アルドステロン産生副腎皮質腺腫における（プロ）レニン受容体の発現増加 (2014)
  • Author(s): 高橋和広、山本肇、金子桐子、大場浩史、森本玲、佐藤文俊、戸恒和人
  • Organizer: 第111回日本内科学会講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] ヒト血中プロレニン受容体様免疫活性物質の検討 (2013)
  • Author(s): 戸恒和人、廣瀬卓男、藤原正子、関野宏、佐藤博、高橋和広、今井潤
  • Organizer: 第17回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 千里ライフサイエンスセンター
• [Presentation] レニン・アンジオテンシン系の新規因子、プロレニン受容体の乳癌における発現と腫瘍病態への関与の検討 (2013)
  • Author(s): 大場浩史、西山浩史、金子桐子、廣瀬卓男、戸恒和人、笹野公伸、鈴木貴、高橋和広
  • Organizer: 第17回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 千里ライフサイエンスセンター