Basic research from kidney developmental biology to clinical nephrology: Organ regeneration and disease models
| Project/Area Number |
25461206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Usui Joichi 筑波大学, 医学医療系, 准教授 (70447340)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 内科 / 腎臓病学 / 再生医学 / 発生・分化 / 病理学 / 移植・再生医療 |
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| Outline of Final Research Achievements |
My research about organogenesis using ES, iPS cells has already been published. The present nephrology research included some issues (Tcf21, VEGF and kidney progenitors). A. Tcf21 expression and functional mechanism in glomerular podocytes of various kideny diseases: Tcf21 expression increased in podocytes of human and rat nephrotic syndrome, and then Tcf21 functionally influenced some cellular phenotypes in murine podocyte cell lone. B. Clinicopathology in VEGF inhibitor-associated kidney diseaes: VEGF inhibitors act to maintain glomerular capillaries, and the failure of this construction induced final glomerular damage. C. In vitro assays for murine nephrogenesis: The establishment of nephrogenesis assay system was continued, then some candidate tools were confirmed.
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Soluble vascular endothelial-cadherin levels in patients with sepsis treated with direct hemoperfusion with a polymyxin B-immobilized fiber column2014
Author(s)
Itaru Ebihara, Kouichi Hirayama, Miho Nagai, Megumi Koda, Masanobu Gunji, Yuki Okubo, Taisuke Katayama, Chihiro Sato, Joichi Usui, Kunihiro Yamagata, Masaki Kobayashi
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Journal Title
Ther Apher Dial
Volume: 18
Issue: 3
Pages: 272-278
DOI
Related Report
Peer Reviewed
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