• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basic research from kidney developmental biology to clinical nephrology: Organ regeneration and disease models

Research Project

Project/Area Number 25461206
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

Usui Joichi  筑波大学, 医学医療系, 准教授 (70447340)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords内科 / 腎臓病学 / 再生医学 / 発生・分化 / 病理学 / 移植・再生医療
Outline of Final Research Achievements

My research about organogenesis using ES, iPS cells has already been published. The present nephrology research included some issues (Tcf21, VEGF and kidney progenitors). A. Tcf21 expression and functional mechanism in glomerular podocytes of various kideny diseases: Tcf21 expression increased in podocytes of human and rat nephrotic syndrome, and then Tcf21 functionally influenced some cellular phenotypes in murine podocyte cell lone. B. Clinicopathology in VEGF inhibitor-associated kidney diseaes: VEGF inhibitors act to maintain glomerular capillaries, and the failure of this construction induced final glomerular damage. C. In vitro assays for murine nephrogenesis: The establishment of nephrogenesis assay system was continued, then some candidate tools were confirmed.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (1 results) Remarks (3 results)

  • [Journal Article] The detection of urinary podocytes from drug-induced glomerular thrombotic microangiopathy in advanced cancer patients2016

    • Author(s)
      Usui J et al.
    • Journal Title

      Clin Lab

      Volume: 62 Issue: 12/2016 Pages: 2413-2417

    • DOI

      10.7754/clin.lab.2016.160525

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 腎臓発生研究成果を臨床医療に応用するための基盤研究-臓器再生モデルと腎疾患モデル2016

    • Author(s)
      臼井丈一
    • Journal Title

      BIO Clinica

      Volume: 31 Pages: 62-65

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse mode2015

    • Author(s)
      Nakauchi Y, Yamazaki S, Napier SC, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H
    • Journal Title

      Experimental hematology

      Volume: 43 Issue: 2 Pages: 79-88

    • DOI

      10.1016/j.exphem.2014.10.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulmonary involvements of anti-neutrophil cytoplasmic autoantibody-associated renal vasculitis in Japan2015

    • Author(s)
      Kouichi Hirayama, Masaki Kobayashi, Joichi Usui, Yoshihiro Arimura, Hitoshi Sugiyama, Kousaku Nitta, Eri Muso, Takashi Wada, Seiichi Matsuo, Kunihiro Yamagata
    • Journal Title

      Nephrol Dial Transplant

      Volume: Suppl 1 Issue: suppl_1 Pages: i83-i93

    • DOI

      10.1093/ndt/gfu385

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literature2014

    • Author(s)
      Joichi Usui, Ilya G. Glezerman, Steven P. Salvatore, Chandra B. Chandran, Carlos D. Flombaum, Surya V Seshan
    • Journal Title

      Hum Pathol

      Volume: 45 Issue: 9 Pages: 1918-1927

    • DOI

      10.1016/j.humpath.2014.05.015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Health-related quality of life and prognosis in patients with chronic kidney disease: a 3-year follow-up study2014

    • Author(s)
      Reiko Okubo, Hirayasu Kai, Masanori Kondo, Chie Saito, Keigyo Yoh, Naoki Morito, Joichi Usui, Kunihiro Yamagata
    • Journal Title

      Clin Exp Nephrol

      Volume: 18 Issue: 5 Pages: 697-703

    • DOI

      10.1007/s10157-013-0901-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble vascular endothelial-cadherin levels in patients with sepsis treated with direct hemoperfusion with a polymyxin B-immobilized fiber column2014

    • Author(s)
      Itaru Ebihara, Kouichi Hirayama, Miho Nagai, Megumi Koda, Masanobu Gunji, Yuki Okubo, Taisuke Katayama, Chihiro Sato, Joichi Usui, Kunihiro Yamagata, Masaki Kobayashi
    • Journal Title

      Ther Apher Dial

      Volume: 18 Issue: 3 Pages: 272-278

    • DOI

      10.1111/1744-9987.12215

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 糸球体係蹄の構造異常からみたネフローゼ症候群2013

    • Author(s)
      臼井丈一、長田道夫
    • Journal Title

      内科

      Volume: 112 Pages: 761-766

    • Related Report
      2013 Research-status Report
  • [Journal Article] 胚盤胞補完法による腎再生2013

    • Author(s)
      臼井丈一、中内啓光
    • Journal Title

      腎と透析

      Volume: 75 Pages: 835-838

    • Related Report
      2013 Research-status Report
  • [Presentation] 抗癌化学療法、VEGF阻害薬関連腎障害の臨床病理学的検討2014

    • Author(s)
      臼井丈一、山縣邦弘
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Remarks] 筑波大学腎臓内科学ホームページ

    • URL

      http://www.tsukuba-igaku-kidney.com/up/index.php?mode=s&cate=3&seq=40

    • Related Report
      2015 Research-status Report
  • [Remarks]

    • URL

      http://www.tsukuba-igaku-kidney.com/up/index.php?mode=s&cate=3&seq=40

    • Related Report
      2014 Research-status Report
  • [Remarks] 筑波大学腎臓内科ホームページ研究紹介

    • URL

      http://www.tsukuba-igaku-kidney.com/up/index.php?mode=s&cate=3&seq=40

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi