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Research of biomarkers that predict relapse of rapidly progressive glomerulonephritis and reflect long-term prognosis.

Research Project

Project/Area Number 25461213
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kanazawa Medical Center

Principal Investigator

Kitagawa Kiyoki  独立行政法人国立病院機構(金沢医療センター臨床研究部), その他部局等, その他 (60436821)

Co-Investigator(Kenkyū-buntansha) WADA Takashi  金沢大学大学院医薬保健学総合研究科, 血液情報統御学, 教授 (40334784)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords急速進行性腎炎症候群 / 再燃 / 感染症 / Vasculitis damage index
Outline of Final Research Achievements

The prevention of relapse and infection complications during remission maintenance therapy is required to improve the prognosis of patients with rapidly progressive glomerulonephritis (RPGN). The clinicopathological characteristics of patients with RPGN were examined to determine the risk factors for relapse or infectious complications after remission induction therapy.
As results of this study, the relation of organ damage severity at remission to relapse has been shown for patients with RPGN. In addition, disease activity at diagnosis and severity of organ damage at remission are related to infectious complications. Further investigations of treatment methods for patients with high disease activity at diagnosis and severe organ damage at remission are required to further improve the prognosis of RPGN patients.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Risk factors associated with relapse or infectious complications in Japanese patients with microscopic polyangiitis2015

    • Author(s)
      Kitagawa K, Furuichi K, Sagara A, Shinozaki Y, Kitajima S, Toyama T, Hara A, Iwata Y, Sakai N, Shimizu M, Kaneko S, Wada T; Kanazawa Study Group for Renal Diseases and Hypertension.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Long-term observations of clinicopathological characteristics and outcome of Japanese patients with pauci-immune crescentic glomerulonephritis.2013

    • Author(s)
      Kitagawa K, Furuichi K, Shinozaki Y, Toyama T, Kitajima S, Hara A, Iwata Y, Sakai N, Kaneko S, Wada T; Kanazawa Study Group for Renal Diseases and Hypertension.
    • Journal Title

      Clin Exp Nephrol

      Volume: 17 Issue: 6 Pages: 858-865

    • DOI

      10.1007/s10157-013-0798-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of a newly proposed histopathological classification in Japanese patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.2013

    • Author(s)
      Iwakiri T, Fujimoto S, Kitagawa K, Furuichi K, Yamahana J, Matsuura Y, Yamashita A, Uezono S, Shimao Y, Hisanaga S, Tokura T, Wada T, Kitamura K, Asada Y.
    • Journal Title

      BMC Nephrol

      Volume: 14 Issue: 1 Pages: 125-125

    • DOI

      10.1186/1471-2369-14-125

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ANCA陽性顕微鏡的多発血管炎における再燃および感染症併発に関連する因子の検討2016

    • Author(s)
      北川 清樹,湯浅貴博,越野瑛久,牧石祥平,古市 賢吾,和田 隆志
    • Organizer
      第59回 日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ANCA陽性顕微鏡的多発血管炎における感染症併発の危険因子の検討2014

    • Author(s)
      北川 清樹,伊勢 拓之,古市 賢吾,和田 隆志
    • Organizer
      第57回日本腎臓学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Risk factor associated with relapse in Japanese patients with pauci-immune crescentic glomerulonephritis.2014

    • Author(s)
      Kitagawa K, Kitajima S, Toyama T, Iwata Y, Furuichi K, Kaneko S, Wada T.
    • Organizer
      The ISN Nexus Symposium 2014
    • Place of Presentation
      Bergamo, Italy
    • Year and Date
      2014-04-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Risk factor associated with relapse in Japanese patients with pauci-immune crescentic glomerulonephritis.2014

    • Author(s)
      Kitagawa K, Kitajima S, Toyama T, Iwata Y, Furuichi K, Kaneko S, Wada T.
    • Organizer
      The ISN Nexus Symposium 2014
    • Place of Presentation
      ベルガモ(イタリア)
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinicopathological characteristics and outcomes of Japanese patients with pauci-immune crescentic glomerulonephritis.2013

    • Author(s)
      Kitagawa K, Kitajima S, Toyama T, Iwata Y, Furuichi K, Kaneko S, Wada T.
    • Organizer
      ISN World Congress of Nephrology 2013.
    • Place of Presentation
      香港
    • Related Report
      2013 Research-status Report
  • [Presentation] ANCA陽性顕微鏡的多発血管炎の再燃危険因子の検討2013

    • Author(s)
      北川 清樹,相良 明宏,遠山 直志,北島 信治,岩田 恭宜,清水 美保,古市 賢吾,和田 隆志
    • Organizer
      第56回日本腎臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] ANCA陽性顕微鏡的多発血管炎における感染症併発の危険因子の検討

    • Author(s)
      北川 清樹,伊勢 拓之,古市 賢吾,和田 隆志
    • Organizer
      第57回日本腎臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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