Research of biomarkers that predict relapse of rapidly progressive glomerulonephritis and reflect long-term prognosis.
| Project/Area Number |
25461213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Department of Clinical Research, National Hospital Organization Kanazawa Medical Center |
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Principal Investigator |
Kitagawa Kiyoki 独立行政法人国立病院機構(金沢医療センター臨床研究部), その他部局等, その他 (60436821)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Takashi 金沢大学大学院医薬保健学総合研究科, 血液情報統御学, 教授 (40334784)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 急速進行性腎炎症候群 / 再燃 / 感染症 / Vasculitis damage index |
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| Outline of Final Research Achievements |
The prevention of relapse and infection complications during remission maintenance therapy is required to improve the prognosis of patients with rapidly progressive glomerulonephritis (RPGN). The clinicopathological characteristics of patients with RPGN were examined to determine the risk factors for relapse or infectious complications after remission induction therapy.
As results of this study, the relation of organ damage severity at remission to relapse has been shown for patients with RPGN. In addition, disease activity at diagnosis and severity of organ damage at remission are related to infectious complications. Further investigations of treatment methods for patients with high disease activity at diagnosis and severe organ damage at remission are required to further improve the prognosis of RPGN patients.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Risk factors associated with relapse or infectious complications in Japanese patients with microscopic polyangiitis2015
Author(s)
Kitagawa K, Furuichi K, Sagara A, Shinozaki Y, Kitajima S, Toyama T, Hara A, Iwata Y, Sakai N, Shimizu M, Kaneko S, Wada T; Kanazawa Study Group for Renal Diseases and Hypertension.
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Journal Title
Clin Exp Nephrol.
Volume: 未定
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Validation of a newly proposed histopathological classification in Japanese patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.2013
Author(s)
Iwakiri T, Fujimoto S, Kitagawa K, Furuichi K, Yamahana J, Matsuura Y, Yamashita A, Uezono S, Shimao Y, Hisanaga S, Tokura T, Wada T, Kitamura K, Asada Y.
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Journal Title
BMC Nephrol
Volume: 14
Issue: 1
Pages: 125-125
DOI
Related Report
Peer Reviewed
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