Investigation of chronic inflammation and strategy of new therapy using regulatory T cell in chronic kidney disease

• Project/Area Number: 25461214
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: Kato Sawako 名古屋大学, 医学(系)研究科(研究院), 特任講師 (80625757)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Shoichi 名古屋大学, 大学院医学系研究科, 准教授 (10362253) ; TSUBOI Naotake 名古屋大学, 医学部附属病院, 講師 (50566958) ; YASUDA Yoshinari 名古屋大学, 大学院医学系研究科, 寄附講座准教授 (60432259) ; YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479) ; SATO Waichi 藤田保健衛生大学, 医学部, 准教授 (90508920)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: inflammation / chronic kidney disease / neutrophil / lymphocyte / mortality / 慢性炎症 / リンパ球 / 国際研究者交流 / スウェーデン / 末期腎不全 / 制御性T細胞

Outline of Final Research Achievements

Patients with end-stage renal disease (ESRD), especially those with inflammation, are at an increased risk of premature mortality. We evaluated the association between the neutrophil/lymphocyte ratio (NLR) and cardiovascular events in Japanese ESRD patients who had just started renal replacement therapy (RRT). A high NLR was associated with inflammation and the increased risk of cardiovascular disease.Since increasing neutrophil count reflects inflammation and lower lymphocyte counts may reflect general stress and malnutrition, NLR is hypothesized to be more sensitive at detecting patients at high risk for CVD.

Research Products

• [Int'l Joint Research] Renal Medicine and Baxter Novum/Karolinska Institutet(Sweden)
• [Int'l Joint Research] Institute of Cancer Sciences/University of Glasgow(英国)
• [Journal Article] Telomere attrition and elongation after chronic dialysis initiation in patients with end-stage renal disease. (2016)
  • Author(s): Kato S, Shiels PG, McGuinness D, Lindholm B, Stenvinkel P, Nordfors L, Qureshi AR, Yuzawa Y, Matsuo S, Maruyama S
  • Journal Title: Blood Purification Volume: 41 Issue: 1-3 Pages: 25-33
  • DOI: 10.1159/000440971
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 1. High Ferritin Level and Malnutrition Predict High Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study. (2016)
  • Author(s): Kato S, Lindholm B, Yuzawa Y, Tsuruta Y, Nakauchi K, Yasuda K, Sugiura S, Morozumi K, Tsuboi N, Maruyama S.
  • Journal Title: Blood Purification Volume: 42 Issue: 1 Pages: 56-63
  • DOI: 10.1159/000445424
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development and validation of a short-version checklist for patients undergoing hemodialysis based on the International Classification of Functioning, Disability and Health. (2014)
  • Author(s): Tsutsui H, Ohkubo T, Tsuruta Y, Kato S, Yasuda Y, Oshida Y.
  • Journal Title: Clin Exp Nephrol Volume: Epub
  • Peer Reviewed
• [Journal Article] Neutrophil/lymphocyte ratio as a predictor of cardiovascular events in incident dialysis patients: a Japanese prospective cohort study. (2014)
  • Author(s): Abe T, Kato S, Tsuruta Y, Sugiura S, Katsuno T, Kosugi T, Tsuboi N, Matsuo S, Maruyama S.
  • Journal Title: Clin Exp Neph Volume: Epub
  • Peer Reviewed
• [Journal Article] Patient age and the prognosis of idiopathic membranous nephropathy. (2014)
  • Author(s): Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.
  • Journal Title: PLoS One Volume: 9(10) Issue: 10 Pages: 110376-110376
  • DOI: 10.1371/journal.pone.0110376
  • Peer Reviewed
• [Journal Article] Validity of a checklist for hemodialysis patients based on the International Classification Of Functioning, Disability and Health. (2014)
  • Author(s): Tsutsui H, Ojima T, Tsuruta Y, Kato S, Yasuda Y, Oshida Y.
  • Journal Title: Ther Apher Dial. Volume: 18(5) Issue: 5 Pages: 473-80
  • DOI: 10.1111/1744-9987.12163
  • Peer Reviewed
• [Journal Article] Smoking is a risk factor for the progression of idiopathic membranous nephropathy. (2014)
  • Author(s): Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.
  • Journal Title: PLoS One. Volume: 9 Issue: 6 Pages: e100835-e100835
  • DOI: 10.1371/journal.pone.0100835
  • Peer Reviewed / Open Access
• [Journal Article] A multicenter cross-sectional study of circulating soluble urokinase receptor in Japanese patients with glomerular disease (2014)
  • Author(s): Wada T, Nangaku M, Maruyama S, Imai E, Shoji K, Kato S, Endo T, Muso E, Kamata K, Yokoyama H, Fujimoto K, Obata Y, Nishino T, Kato H, Uchida S, Sasatomi Y, Saito T, Matsuo S.
  • Journal Title: Kidney Int Volume: 85 Issue: 3 Pages: 641-8
  • DOI: 10.1038/ki.2013.544
  • Peer Reviewed / Open Access
• [Presentation] 1. Temporal Loss of Bone Mineral Density is Associated with Cardiovascular Diseases in Japanese Patients Starting Renal Replacement Therapy. (2015)
  • Author(s): Kato S, Maruyama S, lindholm B, Yuzawa Y, Tsuruta Y, Matsuo S.
  • Organizer: The 46th annual meeting of American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-03
  • Int'l Joint Research
• [Presentation] High Ferritin Level and Low Nutrition Status Predicts Higher Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study (2014)
  • Author(s): Sawako Kato, MD, PhD, Shoichi Maruyama, MD, Bengt Lindholm, MD, PhD, Yukio Yuzawa, MD, Yoshinari Tsuruta, MD, Seiichi Matsuo, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Home Blood Pressure Telemonitoring System Among Patients with CKD: An Attempt to Achieve Optimal Blood Pressure Control with Real-Time Remote. (2014)
  • Author(s): Yoshinari Yasuda, MD, PhD, Misao Niwa, Kanako Shibata, Mayumi Kamiya, Imai Junko, Sawako Kato, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Smoking Is a Risk Factor for the Relapse of Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis. (2014)
  • Author(s): Makoto Yamaguchi, MD, Sawako Kato, MD, PhD, Takuji Ishimoto, MD, PhD, Tomoki Kosugi, MD, PhD, Waichi Sato, MD, PhD, Naotake Tsuboi, MD, PhD, Masashi Mizuno, MD, PhD, Yasuhiko Ito, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] 顕正蛋白尿期の2型糖尿病患者におけるアルダクトンの蛋白尿減少効果 (2014)
  • Author(s): 加藤 佐和子
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 透析導入時の血清マグネシウム値と背景因子の関連についての検討 (2014)
  • Author(s): 田中 章仁、加藤 規利、勝野 敬之、尾崎 武徳、加藤 佐和子、小杉 智規、佐藤 和一、坪井 直毅、丸山 彰一、稲熊 大城、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 喫煙と特発性膜性腎症の腎予後との関連性について (2014)
  • Author(s): 山口 真、安藤 昌彦、秋山 真一、加藤 佐和子、勝野 敬之、小杉 智規、佐藤 和一、坪井 直毅、安田 宜成、水野 正司、伊藤 恭彦、松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] アルブミン尿区分評価における早朝尿の重要性 (2014)
  • Author(s): 丹羽 操、安田 宜成、今井 順子、鈴木 進、加藤 佐和子、丸山 彰一、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 腎移植ドナーにおける腎血漿流量と濾過率：健常者における基準値設定の試み (2014)
  • Author(s): 今井 順子、安田 宜成、丹羽 操、鈴木 進、加藤 佐和子、丸山 彰一、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] IS TELOMERE ATTRITION LINKED TO INTERLEUKIN 6 LEVELS BUT NOT WHITE BLOOD CELL COUNTS IN JAPANESE DIALYSIS PATIENTS? (2014)
  • Author(s): Sawako Kato, Bengt Lindholm, Peter Stenvinkel, Paul G Shiels, Louise Nordfors ,Yukio Yuzawa, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: the 51st ERA-EDTA Congress
  • Place of Presentation: オランダ ,アムステルダム
  • Year and Date: 2014-05-31 – 2014-06-03
• [Presentation] Spironolactone improving intrarenal renin-angiotensin system activation in type ２diabetic nephropathy patients with overt albuminuria. (2014)
  • Author(s): Sawako Kato,Shoichi Maruyama, Hirofumi Makino, Jun Wada, Takashi Uzu, Hisazumi Araki,Daisuke Koya,Keizo Kanasaki, Akira Nishiyama,Hiroyuki Kobori, Enyu Imai, Masahiko Ando, Yutaka Oiso, Seiichi Matsuo
  • Organizer: The 14th Asian Pacific Congress of Nephrology
  • Place of Presentation: 品川プリンスホテル(東京都港区)
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] ANTI-PHOSPHOLIPASE A2 RECEPTOR ANTIBODIES FOR MEMBRANOUS NEPHROPATHY WITH NEPHROTIC SYNDROME IN JAPAN. (2013)
  • Author(s): Reiko Muto, Eri Ito, Shinichi Akiyama,Takenori Ozaki, Sawako Kato,Waichi Sato,Shoichi Maruyama, Seiichi Matsuo.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国)
• [Presentation] GFR DISTRIBUTIONS AMONG SCHEDULED CONTRAST-ENHANCED COMPUTED TOMOGRAPHY BEFORE AND AFTER eGFR SELF-REPORT. (2013)
  • Author(s): Yoshinari Yasuda, Kanako Shibata, Sawako Kato, Mutsuharu Hayashi, Motomitsu Goto,Shoichi Maruyama,Seiichi Matuso.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国)
• [Presentation] Neutrophil/Lymphocyte Ratio as a Predictor of Cardiovascular Events in Japanese Patients Starting Renal Replacement Therapy. (2013)
  • Author(s): Sawako Kato, MD, PhD, Bengt Lindholm, MD, PhD, Yukio Yuzawa, MD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta（USA)
• [Presentation] Circulating suPAR in Japanese Patients with Glomerular Diseases: A Multicenter Cross-Sectional Study. (2013)
  • Author(s): Takehiko Wada、Masaomi Nangaku,Shoichi Maruyama,Enyu Imai,Kumi Shoji,SawakoKato,Tomomi Endo,Eri Muso,Kouju Kamata,Hitoshi Yokoyama,KenijiFujimoto,Yoko Obata,Tomoya Nishino,Hideki Kato,Shunya Uchida ,Yoshie Sasatomi, Takao Saito,Seiichi Matsuo
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta（USA)
• [Presentation] 新規透析導入患者における脈圧と平均血圧の検討 (2013)
  • Author(s): 加藤 佐和子、丸山 彰一、安田 宜成、杉浦 祥代、鶴田 良成、湯澤 由紀夫、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 膜性腎症の抗PLA2R抗体と予後規定因子が寛解導入に与える影響 (2013)
  • Author(s): 武藤 玲子、伊藤 衣里、秋山 真一、尾崎 武、加藤 佐和子、佐藤 和一、丸山 彰一、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 腎動態シンチグラフィによるパラアミノ馬尿酸クリアランス値の検証 (2013)
  • Author(s): 今井 順子、安田 宜成、杉浦 由姫乃、松本 祐之、加藤 佐和子、濱田 昌実、丹羽 操、後藤 資実、林 睦晴、柴田 佳菜子、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 慢性腎臓病（CKD）外来患者におけるクレアチニン補正のある尿試験紙の有効性 (2013)
  • Author(s): 丹羽 操、安田 宜成、加藤 佐和子、今井 順子、林 睦晴、濱田 昌実、後藤 資実、松尾 清一、有馬 武史、松山 浩之、松本 祐之
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 腎機能評価における血清Cr、Cys-CとGFR推算式の有効性 (2013)
  • Author(s): 今井 順子、安田 宜成、加藤 佐和子、柴田 佳菜子、松本 祐之、濱田 昌実、丹羽 操、後藤 資実、林 睦晴、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 造影CTオーダ時の腎機能把握とeGFR分布について (2013)
  • Author(s): 柴田 佳菜子、安田 宜成、岩野 信吾、外山 和男、阿知波 正剛、加藤 佐和子、丸山 彰一、中尾 誠、長縄 慎二、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] CKD診療連携における多職種介入の効果 (2013)
  • Author(s): 濱田 昌実、加藤 佐和子、林 睦晴、後藤 資実、安田 宜成、丸山 彰一、松尾 清一
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル松山全日空ホテル(愛媛県松山市)