| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In this sudy, we revealed the decrease of alpha-Klotho(KL) expression in the kidney was associated with the progression of renal interstitial fibrosis in CKD patients and mouse model of focal segmental glomerulosclerosis(FSGS), via reduced effect on epithelial-mesenchymal transition of tubular epithelial cells by KL. However, the decrease of renal KL expression did not significantly affect the progression of glomerulosclerosis in CKD patients and FSGS model mice. In addition, we revealed the decrease of renal KL expression did not significantly affect the progression of glomerulonephritis in lupus model mice. In summary, KL may have a suppressive effect on renal interstitial fibrosis, but not on glomerulosclerosis and glomerulonephritis.
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