Analysis of the effect of alpha-Klotho protein on the progressions of glomerulonephritis
| Project/Area Number |
25461226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWANO MASAYUKI 福井大学, 医学部, 教授 (20275324)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | α-Klotho / FSP-1 / 慢性腎臓病 / 巣状糸球体硬化症 / ループス腎炎 / Klotho / FSP1 / 管内増殖型ループス腎炎 / fibroblastic protein 1 / CKD / α-Klotho蛋白 |
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| Outline of Final Research Achievements |
In this sudy, we revealed the decrease of alpha-Klotho(KL) expression in the kidney was associated with the progression of renal interstitial fibrosis in CKD patients and mouse model of focal segmental glomerulosclerosis(FSGS), via reduced effect on epithelial-mesenchymal transition of tubular epithelial cells by KL. However, the decrease of renal KL expression did not significantly affect the progression of glomerulosclerosis in CKD patients and FSGS model mice. In addition, we revealed the decrease of renal KL expression did not significantly affect the progression of glomerulonephritis in lupus model mice. In summary, KL may have a suppressive effect on renal interstitial fibrosis, but not on glomerulosclerosis and glomerulonephritis.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.2015
Author(s)
Imamaki H, Ishii A, Yokoi H, Kasahara M, Kuwabara T, Mori KP, Kato Y, Kuwahara T, Satoh M, Nakatani K, Saito Y, Tomosugi N, Sugawara A, Nakao K, Mukoyama M, Yanagita M, Mori K.
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Journal Title
PLoS One
Volume: 10
Issue: 7
Pages: 99-106
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism.2014
Author(s)
Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y.
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Journal Title
PLoS One.
Volume: 9(1):e86301
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Suppressed soluble Fms-like tyrosine kinase-1 production aggravates atherosclerosis in chronic kidney disease2014
Author(s)
Matsui M, Takeda Y, Uemura S, Matsumoto T, Seno A, Onoue K, Tsushima H, Morimoto K, Soeda T, Okayama S, Somekawa S, Samejima K, Kawata H, Kawakami R, Nakatani K, Iwano M, Saito Y.
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Journal Title
Kidney Int
Volume: 85(2)
Issue: 2
Pages: 393-403
DOI
Related Report
Peer Reviewed / Open Access
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