| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Diabetic kidney disease is the leading cause of end stage renal disease in Japan. Recent evidence indicates that abnormalities in epigenetics play a causative role in the development of chronic diseases. Epigenetics is a switching mechanism involved in regulation of gene expression by DNA methylation and histone modifications. In the present study, we investigated whether diabetes induces aberrant DNA methylation in the kidney.
We found that abnormalities in DNA methylation underlie persistent expression of genes involved in diabetic kidney disease, such as angiotensinogen and HGF receptor in diabetic mice. Because aberrant DNA methylation was resistant to glycemic therapy, epigenetic abnormalities are likely to maintain persistent expression of genes involved in injury and/or decrease in protective factors. Therapy against abnormal epigenetic modifications may be beneficial for the development of diabetic kidney disease.
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