Renal lipid metabolism in extrarenal vascular injuly

Research Project

Project/Area Number	25461233
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Kidney internal medicine
Research Institution	Juntendo University
Principal Investigator	Suzuki Yusuke 順天堂大学, 医学(系)研究科(研究院), 准教授 (70372935)
Co-Investigator(Kenkyū-buntansha)	SUGAYA Takeshi 順天堂大学, 医学部, 非常勤講師 (40381561) KOBAYASHI Takashi 順天堂大学, 医学部, 助教 (70459056)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	酸化ストレス / L-FABP
Outline of Final Research Achievements	L-FABP has a capacity to bind long-chain fatty acid oxidation products with high affinity, and thus may play roles as an effective endogenous antioxidant in human proximal tubules. We evaluated kidneys for L-FABP Tg and its wild-type littermates (WT) mice at 24hr after middle cerebral artery occlusion and reperfusion (MCAO). There were clear differences in the renal lipid metabolism between WT and L-FABP Tg mice, suggesting that one of underlying mechanisms in brain-renal association.

Report

(4 results)