Renal lipid metabolism in extrarenal vascular injuly
| Project/Area Number |
25461233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
Suzuki Yusuke 順天堂大学, 医学(系)研究科(研究院), 准教授 (70372935)
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| Co-Investigator(Kenkyū-buntansha) |
SUGAYA Takeshi 順天堂大学, 医学部, 非常勤講師 (40381561)
KOBAYASHI Takashi 順天堂大学, 医学部, 助教 (70459056)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 酸化ストレス / L-FABP |
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| Outline of Final Research Achievements |
L-FABP has a capacity to bind long-chain fatty acid oxidation products with high affinity, and thus may play roles as an effective endogenous antioxidant in human proximal tubules. We evaluated kidneys for L-FABP Tg and its wild-type littermates (WT) mice at 24hr after middle cerebral artery occlusion and reperfusion (MCAO). There were clear differences in the renal lipid metabolism between WT and L-FABP Tg mice, suggesting that one of underlying mechanisms in brain-renal association.
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Report
(4 results)
Research Products
(3 results)
