Foxc1/2 transcription factors and glomerulosclerosis
| Project/Area Number |
25461234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松阪 泰二 東海大学, 医学部, 教授 (50317749)
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIKAWA Iekuni 東海大学, 医学部, 客員教授 (80317768)
MIYAZAKI Yoichi 東京慈恵会医科大学, 医学部, 教授 (60266690)
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| Research Collaborator |
OHTSUKA Masato 東海大学, 医学部, 准教授 (90372945)
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 糸球体硬化 / 転写因子 / フォークヘッド / ポドサイト / フォークヘッド転写因子 / 尿タンパク / ポドサイト傷害 / Foxc1 / Foxc2 / 腎発生 |
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| Outline of Final Research Achievements |
Foxc1 and Foxc2 (Foxc1/2) are transcription factors involved in many biological processes including kidney development. Roles of Foxc1/2 in kidney were examined by conditional knockout mice.
Deletion of Foxc2 from early kidney development by Pax2-Cre resulted in kidney hypoplasia accompanied by glomerular cysts. Mice with an innate podocyte-specific deletion of Foxc1/2 by Nephrin-Cre developed massive proteinuria within 2 weeks after birth. Deletion of Foxc1/2 in adulthood by inducible-Cre resulted in development of massive proteinuria and glomerulosclerosis. Comprehensive gene expression analysis revealed that Foxc1/2 control genes necessary for podocyte function such as podocin and Cxcl12.
These results demonstrate critical roles for Foxc1/2 not only in kidney development but also podocyte maitenance.
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Report
(6 results)
Research Products
(12 results)
