| Project/Area Number |
25461236
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Tsuboi Nobuo 東京慈恵会医科大学, 医学部, 講師 (40408422)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ネフロン数 / 糸球体 / 剖検 |
|---|
| Outline of Final Research Achievements |
Kidneys from 27 Japanese male subjects were divided into three age-matched groups: normotensives (n=9), hypertensive (n=9), and CKD (n=9). Total nephron number (Nglom) and mean glomerular volume (Vglom) were estimated by design-based stereology. Nglom was significantly lower in hypertensives (423,498 + 89,716) than in normotensives (666,140 + 159,755) (P<0.001), even though eGFR was similar in the two groups (P=0.19). CKD patients (312,277 + 91,160) had significantly fewer nephrons than hypertensives (P<0.05) and normotensives (P<0.0001). Nglom was the best morphological predictor of eGFR (R2: 0.46; P<0.001). This study shows for the first time in humans that nephron number predicts eGFR.
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