| Project/Area Number |
25461237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Hiroki 金沢医科大学, 医学部, 助教 (10350761)
ATSUMI Hirokatsu 金沢医科大学, 医学部, 助教 (70460342)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腎移植 / 移植腎機能障害 / アディポサイトカイン / non-classical HLA分子 / 膠原繊維 / 抗HLA抗体 / 糸球体線維化 / non classical HLA分子 / アデポサイトカイン |
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| Outline of Final Research Achievements |
We constructed the cohort of 132 renal allograft transplanted patients, and analyzed the outcomes of renal and actuarial survival. As the results, 1) Serum high- and low-molecular-weight adiponectin (ADPN) fractions were related to the development of both cardiovascular diseases and post-transplant diabetes, and renal allograft function. 2) The gamma;-H2AX (a marker of double-strand DNA breaks) and Collagen type VI expression in renal allograft glomeruli were positively correlated with the duration of the post-renal transplant period. 3) The alteration of Th1, Th2, Th17, Treg (Foxp3+) subsets and non-classical HLA-G5 molecules were found in the early stage of allograft transplantation. In addition, higher serum HLA-G5 level was selected as a protective factor for renal allografts after 60 months.
Conclusion: In Japanese renal allograft recipients, ADPN fractions and non-classical HLA -G molecules were significant factors for the long-term allograft survival and complications.
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