| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Maternal exposure to overnutrition during fetal development contributes torenal damage in offspring. Female Sprague-Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating. After 4 weeks postpartum, all the offspring were fed N diet, and followed by 12 weeks. Serum adiponectin levels of 1-day- and 4-week-old HFF-offspring were significantly lower. Urinary albumin excretion levels werehigher than those of N-offspring at the same age, whose levels at 16-week old were inversely correlated with plasma adiponectin. HFF-offspring at 16-week old exhibited glomerulosclerosis, hyperglycemia, and high mean blood pressure associated with reduced podocin and increased transforming growth factor-beta1 expression in the kidneys. Exposure to maternal HFF-diet during fetal and early postnatal development induces hypoadiponectinemia in offspring, which might cause renal injury and metabolic derangements later in life.
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