Maternal exposure to high-fat and high-fructose diet evokes hypoadiponectinemia and kidney injury in rat offspring.
Project/Area Number |
25461239
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Kurume University |
Principal Investigator |
Fukami Kei 久留米大学, 医学部, 教授 (80309781)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 腎障害 / アディポネクチン / 母体環境 / メタボリックシンドローム / 高血圧 / 酸化ストレス / アルブミン尿 / 糖尿病性腎症 / 蛋白尿 |
Outline of Final Research Achievements |
Maternal exposure to overnutrition during fetal development contributes torenal damage in offspring. Female Sprague-Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating. After 4 weeks postpartum, all the offspring were fed N diet, and followed by 12 weeks. Serum adiponectin levels of 1-day- and 4-week-old HFF-offspring were significantly lower. Urinary albumin excretion levels werehigher than those of N-offspring at the same age, whose levels at 16-week old were inversely correlated with plasma adiponectin. HFF-offspring at 16-week old exhibited glomerulosclerosis, hyperglycemia, and high mean blood pressure associated with reduced podocin and increased transforming growth factor-beta1 expression in the kidneys. Exposure to maternal HFF-diet during fetal and early postnatal development induces hypoadiponectinemia in offspring, which might cause renal injury and metabolic derangements later in life.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Maternal exposure to high-fat and high-fructose diet evokes hypoadiponectinemia and kidney injury in rat offspring2016
Author(s)
Nana Obara-Yamada, Sho-ichi Yamagishi, Yusuke Kaida, Miyuki Yokoro, Kensei Taguchi, Yosuke Nakayama, Ryotaro Ando, Katsuhiko Asanuma, Takanori Matsui, Seiji Ueda, Seiya Okuda, and Kei Fukami
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Journal Title
Clinical and Experimental Nephrology
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Carnitine deficiency is associated with late-onset hypogonadism and depression in uremic men with hemodialysis2014
Author(s)
Fukami K, Yamagishi S, Sakai K, Kaida Y, Obayashi A, Nakayama Y, Ando R, Obara N, Ueda S, Wada Y, Okuda S
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Journal Title
AGING MALE
Volume: 17
Issue: 4
Pages: 238-242
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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