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Establishment of a high sensitivity measurement system for soluble angiotensin IV receptor and evaluation of the utility

Research Project

Project/Area Number 25461245
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Fukui

Principal Investigator

Konoshita Tadashi  福井大学, 医学部, 准教授 (40270954)

Co-Investigator(Renkei-kenkyūsha) ZENIMARU YASUO  福井大学, 医学部附属病院, 特命助教 (20397269)
FUJII MIKI  福井大学, 医学部附属病院, 病院助教 (10401978)
IMAGAWA MICHIKO  福井大学, 医学部附属病院, 特命助教 (70464055)
ICHIKAWA MAI  福井大学, 医学部附属病院, 医員 (30646659)
YAMADA MIKA  福井大学, 医学部附属病院, 医員 (90646655)
Research Collaborator SUZUKI JINYA  医学部附属病院, 講師 (20293417)
YAMAMOTO KATSUSHI  福井大学, 医学部附属病院, 医員 (40753950)
NAKAYA TAKAHIRO  福井大学, 医学部附属病院, 医員 (50750353)
SAKAI AI  福井大学, 医学部附属病院, 医員 (40750352)
MAKINO YASUKAZU  福井大学, 医学部, 大学院生
SATO SATSUKI  福井大学, 医学部, 大学院生
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsアンジオテンシンIV受容体 / LNPEP / IRAP / レニン-アンジオテンシン系 / 高血圧 / 糖尿病 / 糖尿病性腎症
Outline of Final Research Achievements

We had identified Angiotensin IV (AT4) receptor as a hypertension/diabetes specific gene through genetic DNA chip analysis and we had already established a measurement system for this AT4. This time we tried to improve the sensitivity of the measurement by monoclonal antibody methods and as a result we could established a next generation measurement system for AT4 with largely improved sensitivity. This measurement system would be of use for medical care of life-style related diseases.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2011

All Journal Article (14 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (16 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression.2015

    • Author(s)
      Makino Y, Konoshita T, Omori A, Maegawa N, Nakaya T, Ichikawa M, Yamamoto K, Wakahara S, Ishizuka T, Onoe T, Nakamura H; Genomic Disease Outcome Consortium (G-DOC) Study Investigators
    • Journal Title

      PLoS One.

      Volume: 10(9) Issue: 9 Pages: e0137469-e0137469

    • DOI

      10.1371/journal.pone.0137469

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] レニン‐アンジオテンシン系遺伝子多型と2型糖尿病発症の関連解析2015

    • Author(s)
      市川麻衣,此下忠志
    • Journal Title

      Angiotensin Research

      Volume: 12 Pages: 48-50

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 高血圧症とRASバイオマーカー-特にレニン遺伝子と血漿レニン活性について-2015

    • Author(s)
      此下忠志,中屋隆裕,市川麻衣,山本勝司,牧野耕和
    • Journal Title

      Angiotensin Research

      Volume: 12 Pages: 194-199

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Determinants of plasma renin activity - Role of a human renin gene variant as a genetic factor.2014

    • Author(s)
      Konoshita T, Nakaya T, Sakai A, Yamada M, Ichikawa M, Sato S, Imagawa M, Fujii M, Yamamoto K, Makino Y, Arakawa K, Suzuki J, Ishizuka T, Nakamura H
    • Journal Title

      Medicine

      Volume: 93 Issue: 29 Pages: e354-e354

    • DOI

      10.1097/md.0000000000000354

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus: a modest but significant effect of aldosterone synthase.2014

    • Author(s)
      Ichikawa M, Konoshita T, Nakaya T, Yamamoto K, Yamada M, Sato S, Imagawa M, Makino Y, Fujii M, Zenimaru Y, Arakawa K, Suzuki J, Ishizuka T, Nakamura H
    • Journal Title

      Acta Diabetol

      Volume: 51 Issue: 4 Pages: 595-599

    • DOI

      10.1007/s00592-014-0561-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pedal Edema in a Female of RS3PE.2014

    • Author(s)
      Hattori K, Konoshita T, Wakahara S, Miyamori I
    • Journal Title

      J Postgrad Med

      Volume: 60 Issue: 2 Pages: 211-211

    • DOI

      10.4103/0022-3859.132369

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blue Toe in a Male of Cholesterol Embolization Syndrome.2014

    • Author(s)
      Arakawa K, Konoshita T, Makino Y, Ishizuka T
    • Journal Title

      Clin Med

      Volume: 14 Issue: 6 Pages: 688-689

    • DOI

      10.7861/clinmedicine.14-6-688

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 診療の極意「その一言!」「ご家族のためにも、健康で長生きしましょう」2014

    • Author(s)
      此下忠志
    • Journal Title

      生活習慣病News&Views

      Volume: 35 Pages: 14-14

    • Related Report
      2014 Research-status Report
  • [Journal Article] Genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus: a modest but significant effect of aldosterone synthase.2014

    • Author(s)
      Ichikawa M, Konoshita T, Nakaya T, Yamamoto K, Yamada M, Sato S, Imagawa M, Makino Y, Fujii M, Zenimaru Y, Arakawa K, Suzuki J, Ishizuka T, Nakamura H
    • Journal Title

      Acta Diabeto

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiokeratoma in a Man with Fabry Disease.2013

    • Author(s)
      Mutoh H, Konoshita T, Onoe T, Makino Y, Arakawa K, Nakamura H
    • Journal Title

      Am J Med Sci

      Volume: 346 Issue: 4 Pages: 302-302

    • DOI

      10.1097/maj.0b013e3182639555

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集「CKDと動脈硬化」,Part4 CKDにおける高血圧治療,3.CCBの適応と限界2013

    • Author(s)
      此下忠志,山田実夏,市川麻衣,藤井美紀
    • Journal Title

      動脈硬化予防

      Volume: 12 Pages: 50-57

    • Related Report
      2013 Research-status Report
  • [Journal Article] 特集 エビデンスからみた降圧薬の長所と短所,カルシウム拮抗薬の長所と短所2013

    • Author(s)
      此下忠志,山田実夏,市川麻衣,藤井美紀
    • Journal Title

      循環器内科

      Volume: 74 Pages: 345-350

    • Related Report
      2013 Research-status Report
  • [Journal Article] 心腎血管病の予測マーカー、アルブミン尿を低下させるCa拮抗薬は何か-代表的4系統Ca拮抗薬の比較-2013

    • Author(s)
      此下忠志
    • Journal Title

      循環plus

      Volume: 13 Pages: 7-9

    • Related Report
      2013 Research-status Report
  • [Journal Article] The Genomic Disease Outcome Consortium (G-DOC) Study Investigators : A crossover comparison of urinary albumin excretion as a new surrogate marker for cardiovascular disease among 4 types of calcium channel blockers2011

    • Author(s)
      Konoshita, T
    • Journal Title

      Int.J.Cardiol.

      Volume: (in press) Issue: 2 Pages: 448-452

    • DOI

      10.1016/j.ijcard.2011.10.133

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Angiotensinase A(ENPEP)遺伝子型と糖尿病性腎症の関連解析2015

    • Author(s)
      坂井亜衣,帰山沙織,古谷真知,中屋隆裕,山田実夏,市川麻衣,佐藤さつき,今川美智子,山本勝司,藤井美紀,銭丸康夫,鈴木仁弥,牧野耕和,石塚 全,加藤規弘,此下忠志
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      松山
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] メタボリックシンドロームにおけるレニン-アンジオテンシン系2015

    • Author(s)
      市川麻衣,浦邊真知,帰山沙織,中屋隆裕,坂井亜衣,山田実夏,佐藤さつき,今川美智子,山本勝司,牧野耕和,藤井美紀,銭丸康夫,鈴木仁弥,石塚 全,此下忠志
    • Organizer
      第38回日本高血圧学会総会,
    • Place of Presentation
      松山
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] アンジオテンシン変換酵素遺伝子型と高血圧-2型糖尿病コホートにおける関連解析2015

    • Author(s)
      中屋隆裕,帰山沙織,浦邊真知,坂井亜衣,山田実夏,市川麻衣,佐藤さつき,今川美智子,山本勝司,藤井美紀,銭丸康夫,鈴木仁弥,牧野耕和,石塚 全,此下忠志
    • Organizer
      第38回日本高血圧学会総会,
    • Place of Presentation
      松山
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] N/L type calcium channel blocker, cilnidipine, leads to less elevation of plasma aldosterone compared to l type calcium channel blocker, amlodipine besilate on the top of valsartan administration.2015

    • Author(s)
      Konoshita T, Nakaya T, Sakai A, Yamada M, Ichikawa M, Yamamoto K, Sato S, Imagawa M, Makino Y, Fujii M, Zenimaru Y, Suzuki J, Ishizuka T
    • Organizer
      25th European Meeting on Hypertension
    • Place of Presentation
      Milan
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus.2015

    • Author(s)
      Ichikawa M, Konoshita T, Nakaya T, Sakai A, Yamada M, Yamamoto K, Sato S, Imagawa M, Makino Y, Fujii M, Zenimaru Y, Suzuki J, Ishizuka T
    • Organizer
      25th European Meeting on Hypertension
    • Place of Presentation
      Milan
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ENPEP(angiotensinase A)遺伝子多型と高血圧症の相関解析2014

    • Author(s)
      坂井亜衣,中屋隆裕,山本勝司,山田実夏,市川麻衣,今川美智子,牧野耕和,藤井美紀,銭丸康夫,鈴木仁弥,石塚 全,ジャギデジャ ムードレイ,加藤規弘,此下忠志
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] アルドステロン合成酵素遺伝子多型と慢性腎臓病の相関解析2014

    • Author(s)
      中屋隆裕,坂井亜衣,山本勝司,山田実夏,市川麻衣,佐藤さつき,今川美智子,牧野耕和,藤井美紀,銭丸康夫,鈴木仁弥,石塚 全,ジャギデジャ ムードレイ,此下忠志
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢2型糖尿病における血圧と循環レニン-アンジオテンシン系の特性2014

    • Author(s)
      山本勝司,中屋隆裕,坂井亜衣,山田実夏,市川麻衣,佐藤さつき,今川美智子,牧野耕和,藤井美紀,銭丸康夫,鈴木仁弥,石塚 全,ジャギデジャ ムードレイ,此下忠志
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] レニン-アンジオテンシン系遺伝子と2型糖尿病の関連解析2014

    • Author(s)
      市川麻衣,中屋隆裕,坂井亜衣,山本勝司,山田実夏,佐藤さつき,今川美智子,牧野耕和,藤井美紀,銭丸康夫,鈴木仁弥,石塚 全,ジャギデジャ ムードレイ,此下忠志
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Determinants of plasma renin activity – role of a human renin gene variant as a genetic factor.2014

    • Author(s)
      Konoshita T, Nakaya T, Yamamoto K, Yamada M, Ichikawa M, Sato S, Imagawa M, Makino Y, Fujii M, Zenimaru Y, Arakawa K, Suzuki J, Ishizuka T, Nakamura H
    • Organizer
      24th European Meeting on Hypertension
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2014-06-13 – 2014-06-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢2型糖尿病症例の特徴,特に循環レニン-アンジオテンシン系について2014

    • Author(s)
      山本勝司,中屋隆裕,山田実夏,市川麻衣,佐藤さつき,今川美智子,牧野耕和,藤井美紀,銭丸康夫,鈴木仁弥,此下忠志
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] レニン-アンジオテンシン系遺伝子多型と2型糖尿病発症の関連-アルドステロン合成酵素遺伝子型の意義-2014

    • Author(s)
      市川麻衣,山本勝司,中屋隆裕,山田実夏,佐藤さつき,今川美智子,牧野耕和,藤井美紀,銭丸康夫,鈴木仁弥,此下忠志,石塚 全,プレム ガチラム,ジャギデジャ ムードレイ
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Genetic variation in the renin-angiotensin-aldosterone system and renal survival in Japanese patients with diabetic nephropathy.2014

    • Author(s)
      Makino Y, Konoshita T, Fujii M, Zenimaru Y, Ishizuka T
    • Organizer
      2014 Annual Scientific Meeting of American Society of Hypertension
    • Place of Presentation
      New York, USA
    • Year and Date
      2014-05-16 – 2014-05-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Measurement of soluble angiotensin-IV receptor (s-AT4), identified through systemic transcriptome analysis of hypertensive and diabetic renal tissue.2013

    • Author(s)
      Konoshita T, Yamada M, Ichikawa M, Sato S, Imagawa M, Makino Y, Fujii M, Wakahara S, Zenimaru Y, Arakawa K, Suzuki J, Kato N
    • Organizer
      23rd European Meeting on Hypertension
    • Place of Presentation
      Milan (Italy)
    • Related Report
      2013 Research-status Report
  • [Presentation] 網羅的発現遺伝子解析で抽出された高血圧/糖尿病関連因子、アンジオテンシンIV受容体可溶成分(sAT4)の測定2013

    • Author(s)
      此下忠志, 山田実夏, 市川麻衣, 木村朋子, 佐藤さつき, 今川美智子, 牧野耕和, 藤井美紀, 銭丸康夫, 若原成行, 稲葉聡, 鈴木仁弥
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京、東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] 網羅的発現遺伝子解析で抽出された糖尿病関連因子、Insulin regulated aminopeptidase(IRAP/AT4)可溶成分の測定2013

    • Author(s)
      此下忠志, 山田実夏, 市川麻衣, 木村朋子, 佐藤さつき, 今川美智子, 牧野耕和, 藤井美紀, 銭丸康夫, 若原成行, 稲葉聡, 鈴木仁弥
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本、熊本市民会館
    • Related Report
      2013 Research-status Report
  • [Book] 多発性嚢胞腎診療ガイドライン2014

    • Author(s)
      日本腎臓学会
    • Total Pages
      69
    • Publisher
      東京医学社
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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