The role of clock genes in non-dipper hypertension

Research Project

Project/Area Number	25461248
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Kidney internal medicine
Research Institution	Hiroshima University
Principal Investigator	Nakashima Ayumu 広島大学, 原爆放射線医科学研究所, 特任助教 (40448262)
Co-Investigator(Kenkyū-buntansha)	HIGASHI YUKIHITO 広島大学, 原爆放射線医科学研究所, 教授 (40346490) MASAKI TAKAO 広島大学病院, 教授 (30397913) KAWAMOTO TAKESHI 広島大学, 社会産学連携室, 特任教授 (50224861)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	時計遺伝子 / 血圧 / DEC1 / CLOCK / 日内変動 / Na-K-ATPase / 概日リズム
Outline of Final Research Achievements	Tne Na-K-ATPase beta 1 (Atp1b1) mRNA and protein levels in mouse kidney, aorta and heart showed a circadian rhythm. Furthermore, Dec1-deficient mice showed enhanced Atp1b1 expression in these tissues and reduced blood pressure. In contrast, Clock-mutant mice showed reduced Atp1b1 expression and elevated blood pressure.