Treatment approach against cardiovascular disease in hemodialysis patients through improvement of uremic toxins
Project/Area Number |
25461250
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Osaka City University |
Principal Investigator |
Mori Katsuhito 大阪市立大学, 大学院医学研究科, 講師 (60382040)
|
Co-Investigator(Kenkyū-buntansha) |
SHOJI Tetsuo 大阪市立大学, 大学院医学研究科, 准教授 (40271192)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | fetuin-A / インドキシル硫酸 / 心血管イベント / 血液透析 / CKD / 尿毒症 / 血管石灰化 / 培養肝細胞 / 透析 |
Outline of Final Research Achievements |
Fetuin-A is a liver-derived circulating protein that has potent calcification-inhibitory activity. Uremic patients exhibit decreased serum fetuin-A levels, increased vascular calcification and elevated cardiovascular mortality. Because the mechanisms for fetuin-A deficiency are unknown, we hypothesised that some uremic toxins suppressed hepatic fetuin-A production, which resulted in accelerated vascular calcification and poor outcome. Among these potential candidates, indoxyl sulfate (IS) has highly toxic properties. We examined the direct effects of IS on hepatic fetuin-A expression using the human hepatoma HepG2 cell line. IS suppressed hepatic fetuin-A expression by activating the aryl hydrocarbon receptor, suggesting a relationship among uremia, fetuin-A deficiency and cardiovascular mortality.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Indoxyl sulfate suppresses hepatic fetuin-A expression via the aryl hydrocarbon receptor in HepG2 cells2015
Author(s)
Ochi A, Mori K, Nakatani S, Emoto M, Morioka T, Motoyama K, Fukumoto S, Imanishi Y, Shoji T, Ishimura E, Inaba M
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Journal Title
Nephrology, dialysis, transplantation
Volume: 30
Issue: 10
Pages: 1683-1692
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Direct inhibitory effects of pioglitazone on hepatic fetuin-A expression.2014
Author(s)
Ochi A, Mori K, Emoto M, Nakatani S, Morioka T, Motoyama K, Fukumoto S, Imanishi Y, Koyama H, Ishimura E, Inaba M
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e88704-e88704
DOI
Related Report
Peer Reviewed
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[Presentation] Indoxyl Sulfate Suppresses Hepatic Fetuin-A Expression through Aryl Hydrocarbon Receptor2014
Author(s)
Ochi A, Mori K, Nakatani S, Emoto M, Motoyama K, Morioka T, Fukumoto S, Imanishi Y, Shoji T, Ishimura E, Inaba M
Organizer
ASN Kidney Week 2014
Place of Presentation
Philadelphia (USA)
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] Effects of Pioglitazone on Fetuin-A Expression in Hepatocytes2013
Author(s)
Ochi A, Mori K, Emoto M, Nakatani S, Morioka T, Motoyama K, Fukumoto S, Inaba M
Organizer
American Diabetes Association, 73rd Scientific Sesseions
Place of Presentation
Chicago, IL, USA
Related Report