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Effect of magnesium in renal dysfunction to phosphorus diuretic and anti-aging factor.

Research Project

Project/Area Number 25461251
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionWakayama Medical University

Principal Investigator

Ohya Masaki  和歌山県立医科大学, 医学部, 講師 (90550301)

Co-Investigator(Kenkyū-buntansha) Takashi Shigematsu  和歌山県立医科大学, 医学部, 教授 (30187348)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords血管石灰化 / 慢性腎臓病 / リン / マグネシウム / カルシウム / PTH / FGF23 / TRPM / Klotho / FGF-23
Outline of Final Research Achievements

A high serum level of Mg is frequent in uremic patients with end-stage renal disease just prior to beginning HD. There was a significant correlation between the serum Mg and iPTH levels. Furthermore, the serum Mg level was an independent factor apart from the other factors regulating iPTH. Aortic rings obtained from rats were incubated for 10 days. The inorganic phosphate (Pi) concentration of the medium was increased to induce VC. The mineral composition of the calcification was analyzed using Fourier transform infrared (FTIR) spectroscopic imaging, SEM-EDX mapping. Exposure to high Pi concentration augments aortic calcification via an increase in Pit-1, which mainly contains calcium phosphate. Exposure to high Pi and high Ca concentration augments aortic calcification via an increase in Pit-1.When several concentrations of Mg add in the HPi medium, VC quantified as aortic calcium (Ca) content was suppressed in a dose-dependent manner.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Mineral Composition of Phosphate-Induced Calcification in a Rat Aortic Tissue Culture Model2015

    • Author(s)
      Sonou T, Ohya M, Yashiro M, Masumoto A, Nakashima Y, Ito T, Mima T, Negi S, Kimura-Suda H, Shigematsu T.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 22 Issue: 11 Pages: 1197-1206

    • DOI

      10.5551/jat.28647

    • NAID

      130005106119

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Significance of serum magnesium as an independent correlative factor on the parathyroid hormone level in uremic patients.2014

    • Author(s)
      Ohya M, Negi S, Sakaguchi T, Koiwa F, Ando R, Komatsu Y, Shinoda T, Inaguma D, Joki N, Yamaka T, Ikeda M, Shigematsu T.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 99 Issue: 10 Pages: 3873-8

    • DOI

      10.1210/jc.2013-4396

    • Related Report
      2014 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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