Large-scale observational study of hemodialysis patients designed to evaluate associations between practice patterns, biomarkers, and clinical outcomes
| Project/Area Number |
25461257
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | 慢性腎臓病 / 血液透析 / 生命予後 / 大規模観察研究 / バイオマーカー |
|---|
| Outline of Final Research Achievements |
In a retrospective cohort study of 2,292 hemodialysis patients, treatment with lanthanum was independently associated with a significant survival benefit in hemodialysis patients with inadequately controlled hyperphosphatemia. We found no significant associations of better glycemic control or use of inhibitors of renin-angiotensin system with improved survival.
We also performed a prospective cohort study: a total of 654 hemodialysis patients were recruited and were prospectively followed for 3 years. Baseline median FGF23 levels and mean soluble Klotho levels were 1,878 pg/ml and 377 pg/ml, respectively. We will evaluate associations of FGF23 levels, soluble Klotho levels, and other patient characteristics with mortality and cardiovascular events.
|
Report
(4 results)
Research Products
(28 results)
-
-
-
-
-
-
[Journal Article] Recent changes in therapeutic approaches and association with outcomes among patients with secondary hyperparathyroidism on chronic hemodialysis: the DOPPS study.2015
Author(s)
Tentori F, Wang M, Bieber BA, Karaboyas A, Li Y, Jacobson SH, Andreucci VE, Fukagawa M, Frimat L, Mendelssohn DC, Port FK, Pisoni RL, Robinson BM
-
Journal Title
Clin J Am Soc Nephrol.
Volume: 10
Issue: 1
Pages: 98-109
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Impact of mineral metabolism on mortality in hemodialysis patients: Serum phosphate level should be controlled firstly and consistently.2013
Author(s)
Taniguchi M, Fukagawa M, Fujii N, Hamano T, Shoji T, Yokoyama K, Nakai S, Shigematsu T, Iseki K, Tsubakihara Y, Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy
-
Journal Title
Ther Aphr Dial
Volume: 17(2)
Pages: 221-228
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
