Roles of brain renin-angiotensin system in the chronic blood pressure lowerig effects by renal denervation

• Project/Area Number: 25461258
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Morimoto Satoshi 東京女子医科大学, 医学部, 准教授 (80257534)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 交感神経活動 / 高血圧 / レニンーアンジオテンシン系 / （プロ）レニン受容体 / レニン－アンジオテンシン系 / (プロ）レニン受容体 / レニン-アンジオテンシン系 / 交感神経 / レニン・アンジオテンシン系

Outline of Final Research Achievements

This study was planned to investigate the central mechanisms involved in the chronic blood pressure lowering effects by catheter-based renal denervation (RDN). In the HTN-3 Study, however, RDN failed to show significantly greater blood pressure reduction compared with sham procedure in resistant hypertension, directing questions at the blood pressure lowering effects of RDN. Therefore, the study theme was changed to investigation of roles of brain (pro)renin receptor in spontaneously hypertensive rats (SHRs). I am examining if (pro)renin receptor expression is increased in brain of SHRs and the roles of brain (pro)renin receptor in the regulation of blood pressure, brain oxidative stress, vasopressin secretion, sympathetic nerve activity, drinking behavior, and salt preference in these rats.