Development of real time evaluation method of GRF using viscographic MRI.

• Project/Area Number: 25461260
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: Umeda Masahiro 明治国際医療大学, 公私立大学の部局等, 教授 (60223608)
• Co-Investigator(Kenkyū-buntansha): Tanaka Chuzo 明治国際医療大学, 医学教育研究センター, 教授 (80163541) ; HIGUCHI Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700) ; WATANABE Yasuharu 明治国際医療大学, 医学教育研究センター, 講師 (90454537) ; KAWAI Yuko 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腎臓 / GRF / 腎機能 / 心拍 / 血圧 / フィルタ / ADC / DWI / 拡散 / MRI / 腎 / 心拍同期 / IVIM / 糸球体

Outline of Final Research Achievements

Apparent diffusion coefficient (ADC) is calculate from diffusion weighted MRIs (DWI) with several b values. The ADC inculde water molecule diffusion and water transport in the tissues. The water transport corresponds to tissue perfusion. The water molecule transfers random direction in the MRI voxel (8 ml - 27 ml). This effect is called intra voxel incoherent motion (IVIM) effect that enlarges ADC by blood flow, that is faster transportation. On the other hand, slow water transportation is induced by diffusion, and osmotic pressure or mechanical pressure gradient in the tissue. The variation of blood pressure driven from cardiac cycle may make the gradient in the tissues. The aim of this study is evaluate the glomerular filtration rate (GFR) of kidney using ADC with different cardiac cycle phase. The ADC with 200 - 700 s/mm2 with different cardiac cycle were changed. This changes of ADC without blood flow may show renal function.

Research Products

• [Journal Article] Inter‐hemispheric desynchronization of the human MT+ during visually induced motion sickness (2015)
  • Author(s): Miyazaki J, Yamamoto H, Ichimura Y, Yamashiro H, Murase T, Yamamoto T, Umeda M, Higuchi T.
  • Journal Title: Exp Brain Res. Volume: 233 Issue: 8 Pages: 2421-2431
  • DOI: 10.1007/s00221-015-4312-y
  • NAID: 120005608093
  • Peer Reviewed
• [Journal Article] Diffusion-weighted Line-scan Echo-planar Spectroscopic Imaging Technique to Reduce Motion Artifacts in Metabolite Diffusion Imaging (2015)
  • Author(s): Bito Y, Hirata K, Ebisu T, Kawai Y, Otake Y, Hirata S, Shirai, T, Soutome Y, Ochi H, Yamamoto E, Umeda M, Higuchi T, Tanaka C
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 1 Pages: 43-50
  • DOI: 10.2463/mrms.2014-0024
  • NAID: 130004700397
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Activity in early visual areas predicts interindividual differences in binocular rivalry dynamics. (2014)
  • Author(s): Yamashiro, H., Yamamoto, H., Mano, H., Umeda M., Higuchi, T., & Saiki, J.
  • Journal Title: Journal of Neurophysiology Volume: 111 Issue: 6 Pages: 1090-1202
  • DOI: 10.1152/jn.00509.2013
  • NAID: 120005458271
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MRIの進歩と将来の展望 工学的見地からの可能性を含めて (2014)
  • Author(s): 梅田雅宏
  • Journal Title: 月刊新医療 Volume: 6月号 Pages: 53-55
• [Journal Article] fMRIによる AKA-博田法の検討－第２報ー慢性腰痛の治療前後の副運動２型刺激による脳賦活領域の変化ー (2014)
  • Author(s): 田中忠蔵、村瀬智一、福永雅喜、博田節夫、梅田雅宏、河合裕子、渡邉康晴、樋口敏宏
  • Journal Title: 日本関節運動学的アプローチ医学会誌 Volume: 15 Pages: 53-58
  • Peer Reviewed
• [Journal Article] Selective visualization of rabbit knee cartilage using MR imaging with a double-contrast agent. (2014)
  • Author(s): Kido M, Ikoma K, Hara Y, Matsuda K I, Kawata M, Umeda M, and Kubo T
  • Journal Title: J Magn Reson Imaging Volume: 39 Issue: 5 Pages: 1186-1190
  • DOI: 10.1002/jmri.24282
  • Peer Reviewed
• [Journal Article] Deconvolution analyses with tent functions reveal delayed and long-sustained increases of BOLD signals with acupuncture stimulation. (2013)
  • Author(s): Murase T, Umeda M, Fukunaga M, Tanaka C, Higuchi T
  • Journal Title: Magn Reson Med Sci. Volume: 12 Pages: 121-127
  • NAID: 10031183925
  • Peer Reviewed
• [Journal Article] Relationship between preoperative magnetic resonance imaging and surgical findings: aneurysm wall thickness on high-resolution T1-weighted imaging and contact with surrounding tissue on steady-state free precession imaging. (2013)
  • Author(s): Tenjin H, Tanigawa S, Takadou M, Ogawa T, Mandai A, Nanto M, Osaka Y, Nakahara Y, Umeda M, Higuchi T
  • Journal Title: Neurol Med Chir Volume: 53 Pages: 336-342
  • DOI: 10.1007/978-3-319-02411-0_5
  • ISBN: 9783319024103, 9783319024110
• [Presentation] MEGA-PRESS 法による GABA+ を指標とした fMRS 測定の検討 (2015)
  • Author(s): 村瀬 智一、山城 博幸、山本 洋紀、梅田 雅宏、河合 裕子、萬代 綾子、樋口 敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-10
• [Presentation] 1H-CSI における LCModel 解析データを用いた代謝画像表示ソフトの試作 (2015)
  • Author(s): 梅田 雅宏、村瀬 智一、安田 幸二、渡邉 康晴、河合 裕子、萬代 綾子、樋口 敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-10
• [Presentation] Obesity decrease the eigenvalues of muscles (2015)
  • Author(s): Y.Watanabe, K.Kimura, M.Umeda, T.Murase, T.Higuchi, C.Tanaka and S.Naruse
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] MR spectroscopy における疎性を用いた周波数スペクトル再構成の検討 (2015)
  • Author(s): 笈田 武範、村瀬 智一、梅田 雅宏
  • Organizer: 電子情報通信学会
  • Place of Presentation: 東京都
  • Year and Date: 2015-03-16
• [Presentation] ヒト脳内のGABA測定条件に関する検討 (2015)
  • Author(s): 村瀬智一、梅田雅宏、渡邉康晴、樋口敏宏
  • Organizer: 臨床MR脳機能研究会
  • Place of Presentation: 東京都
  • Year and Date: 2015-03-14
• [Presentation] スパースモデリングの深化によるMRスペクトロスコピーへのデータ駆動学的アプローチ (2014)
  • Author(s): 梅田雅宏、村瀬智一、山本洋紀、浦山慎一、山城博之
  • Organizer: 科学研究費補助金新学術領域研究「スパースモデリングの深化と高次元データ駆動科学の創成」 2014 年度公開シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2014-12-14 – 2014-12-17
• [Presentation] Multiple neural processes underlying binocular rivalry in retinotopic visual areas (2014)
  • Author(s): Yamashiro H, Yamatomo H, Mano H, Umeda M, Higuchi T, Saiki J
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 肥満は筋のeigenvaluesを低下させる (2014)
  • Author(s): 渡邉康晴、木村啓作、梅田雅宏、河合裕子、村瀬智一、樋口敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 京都府
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] locomotive syndromeを視野に入れた筋のコンディション評価法 (2014)
  • Author(s): 木村啓作、渡邉康晴、梅田雅宏、樋口敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 京都府
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 仮想灸刺激に伴う脳活動変化の検討 (2014)
  • Author(s): 村瀬智一、梅田雅宏、福永雅喜、渡邉康晴、樋口敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 京都府
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 呼吸に伴う腎臓の位置変化と腰部刺鍼の検討-3次元MRIによる評価- (2014)
  • Author(s): 村瀬智一、梅田雅宏、新原寿志、渡邉康晴、樋口敏宏
  • Organizer: 全日本鍼灸学会学術大会
  • Place of Presentation: 愛媛県
  • Year and Date: 2014-05-16 – 2014-05-18
• [Presentation] Validation of the Temporal Signal Change Caused by Acupuncture Stimulation with Multi-Band Acquisition (2014)
  • Author(s): Murase T, Umeda M, Fukunaga M, Maruyama K, Kawai Y, Watanabe Y, Tanaka C, Highchi T
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: イタリア・ミラノ
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] 磁性イオン液体を用いた局所シム調整の試み (2013)
  • Author(s): 梅田雅宏, 渡邉康晴, 河合裕子, 村瀬智一, 田中忠蔵, 樋口敏宏
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島
• [Presentation] 1H-MRSI を用いた骨格筋中アセチル -L- カルニチン濃度の運動による変化 (2013)
  • Author(s): 梅田雅宏, 渡邉康晴, 河合裕子, 村瀬智一, 田中忠蔵, 樋口敏宏
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島