| Project/Area Number |
25461266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Teikyo University (2015)
University of Tsukuba (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMAOKA Akira 筑波大学, 医学医療系, 教授 (50192183)
KWAK Shin 東京大学, 大学院医学系研究科(医学部), 客員研究員 (40160981)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMEDA Hiroshi 帝京大学, 医学部, 助教 (10532749)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 筋萎縮性側索硬化症 / RNA編集 / in vivo電気穿孔法 / TDP-43 / TAF15 / microRNA / ADAR2 / 細胞移動 / 相互作用 |
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| Outline of Final Research Achievements |
In amyotrophic lateral sclerosis (ALS), many aggregated proteins and disease causative genes are found. However, the precise mechanism for motoneuronal cell death has been still unclear and we don’t get the path to ALS-treatment. In this study, we found the microRNAs specifically regulated by mutated (M337V) TDP-43. This discovery is considered to be a major foothold for further study. Also it is suggested that TDP-43 and other gene are involved in cell migration process during brain development. This may add the new insight to the mechanisms and the physiological function of the neuronal cell death.
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