The strategy for treatment based on the association cascade with the amyotrophic lateral sclerosis causative genes and RNA editing enzyme
Project/Area Number |
25461266
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Teikyo University (2015) University of Tsukuba (2013-2014) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TAMAOKA Akira 筑波大学, 医学医療系, 教授 (50192183)
KWAK Shin 東京大学, 大学院医学系研究科(医学部), 客員研究員 (40160981)
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Co-Investigator(Renkei-kenkyūsha) |
KAMEDA Hiroshi 帝京大学, 医学部, 助教 (10532749)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 筋萎縮性側索硬化症 / RNA編集 / in vivo電気穿孔法 / TDP-43 / TAF15 / microRNA / ADAR2 / 細胞移動 / 相互作用 |
Outline of Final Research Achievements |
In amyotrophic lateral sclerosis (ALS), many aggregated proteins and disease causative genes are found. However, the precise mechanism for motoneuronal cell death has been still unclear and we don’t get the path to ALS-treatment. In this study, we found the microRNAs specifically regulated by mutated (M337V) TDP-43. This discovery is considered to be a major foothold for further study. Also it is suggested that TDP-43 and other gene are involved in cell migration process during brain development. This may add the new insight to the mechanisms and the physiological function of the neuronal cell death.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases.2016
Author(s)
Yamada K, Kobayashi H, Bo R, Takahashi T, Purevsuren J, Hasegawa Y, Taketani T, Fukuda S, Ohkubo T, Yokota T, Watanabe M, Tsunemi T, Mizusawa H, Takuma H, Shioya A, Ishii A, Tamaoka A, Shigematsu Y, Sugie H, Yamaguchi S.
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Journal Title
Brain Dev.
Volume: 38
Issue: 3
Pages: 293-301
DOI
Related Report
Peer Reviewed
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[Journal Article] A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.2013
Author(s)
Akamatsu, M., Takuma, H., Yamashita, T., Okada, T., Keino-Masu, K., Ishii, K., Kwak, S., Masu, M., and Tamaoka, A.
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Journal Title
Neuroscience Research
Volume: 77
Issue: 4
Pages: 234-241
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Exome analysis reveals a Japanese family with spinocerebellar ataxia, autosomal recessive 1.2013
Author(s)
Ichikawa Y, Ishiura H, Mitsui J, Takahashi Y, Kobayashi S, Takuma H, Kanazawa I, Doi K, Yoshimura J, Morishita S, Goto J, Tsuji S
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Journal Title
J. Neurol. Sci.
Volume: 331
Issue: 1-2
Pages: 158-160
DOI
Related Report
Peer Reviewed
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[Presentation] Two japanese cases of adult onset myopathic form of glutaric acidemia type II2013
Author(s)
S Yamaguchi, K Yamada, H Kobayashi, T Takahashi, Y Hasegawa, J Purevsuren, T Ohkubo, M Watanabe, T Tsunemi, A Ishii, H Takuma, A Tamaoka, Y Shigematsu, S Fukuda
Organizer
12th International Congress of Inborn errors of Metablism
Place of Presentation
Barcelona(スペイン)
Related Report
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