Elucidation of preventive effect of amyloidogenesis by low molecule drugs in FAP

• Project/Area Number: 25461275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Shinshu University
• Principal Investigator: YAZAKI Masahide 信州大学, 学術研究院医学系, 准教授 (70372513)
• Co-Investigator(Renkei-kenkyūsha): SEKIJIMA Yoshiki 信州大学, 学術研究院医学系, 准教授 (60322715)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: FAP / アミロイドーシス / アミロイド融解 / 低分子薬剤 / トランスサイレチン / 線維融解 / ＦＡＰ / amyloid turnover / 肝移植 / ジフルニサル / 野生型TTR

Outline of Final Research Achievements

We studied the effectiveness of low molecule anti-transthyretin (TTR) amyloidosis drugs in TTR-related familial amyloid polyneuropathy (FAP). In liver-transplanted FAP patients, decrease in amount of amyloid deposits was seen in gastroduodenal amyloid after kiver transplantation. The composition ratios of variant and wild-type TTR fluctuated in serially biopsied samples probably due to suppress amyloidogenesis in both variant and wild-type TTR. In a domino liver-transplant recipient who had been started on oral intake of anti-TTR amyloidosis drug from preclinical stage of transmitted FAP, FAP developed 12 years after operation, suggesting that these drugs might have preventive effect against FAP in domino recipients.

Research Products

• [Journal Article] Cerebral amyloid angiopathy in post-transplant patients with hereditary ATTR amyloidosis (2016)
  • Author(s): Sekijima Y, Yazaki M, Oguchi K, 他7名.
  • Journal Title: Neurology Volume: in press
  • Peer Reviewed
• [Journal Article] Recurrence of Waldenström macroglobulinemia accompanied by factor X deficiency (2016)
  • Author(s): 大原慎、萩原政夫、矢﨑正英(7番目）、他6名
  • Journal Title: Rinsho Ketsueki Volume: 57 Issue: 3 Pages: 359-363
  • DOI: 10.11406/rinketsu.57.359
  • NAID: 130005145489
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Carpal tunnel syndrome: a common initial symptom of systemic wild-type ATTR (ATTRwt) amyloidosis. (2016)
  • Author(s): Nakagawa M, Sekijima Y, Yazaki M, Tojo K, Yoshinaga T, Doden T, Koyama J,
  • Journal Title: Ａｍｙｌｏｉｄ Volume: 23 Issue: 1 Pages: 58-63
  • DOI: 10.3109/13506129.2015.1135792
  • Peer Reviewed
• [Journal Article] IL-18 serum concentration is markedly elevated in typical familial Mediterranean fever with M694I mutation and can distinguish it from atypical type. (2016)
  • Author(s): Yamazaki T, Shigemura T, Kobayashi N, Honda K, Yazaki M, Masumoto J, Migita K, Agematsu K.
  • Journal Title: Mod Rheumatol. Volume: 26 Issue: 2 Pages: 315-317
  • DOI: 10.3109/14397595.2014.988861
  • Peer Reviewed / Open Access
• [Journal Article] 血清変異トランスサイレチンのスクリーニング法と生検部位の選択 (2016)
  • Author(s): 矢﨑正英
  • Journal Title: 神経内科 Volume: 84 Pages: 125-131
• [Journal Article] The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantaion. (2015)
  • Author(s): Yoshinaga, T, Yazaki M, Sekijima Y, Kametani F, Miyashita K, Hachiya N, Tanaka T, Koaudo N, Higuchi K, Ikeda S.
  • Journal Title: J Path: Clin Res 2015 Volume: 1 Issue: 2 Pages: 1-8
  • DOI: 10.1002/cjp2.36
  • Peer Reviewed / Open Access
• [Journal Article] Renal AH Amyloidosis Associated With a Truncated Immunoglobulin Heavy Chain Undetectable by Immunostaining. (2015)
  • Author(s): Manabe S, Hatano M, Yazaki M, Nitta K, Nagata M.
  • Journal Title: Am J Kid Dis Volume: 66 Issue: 6 Pages: 1095-1100
  • DOI: 10.1053/j.ajkd.2015.08.016
  • Peer Reviewed
• [Journal Article] Pathological, biochemical, and biophysical characteristics of the transthyretin variant Y114H (p.Y134H) explain its very mild clinical phenotype (2015)
  • Author(s): Sekijima Y, Campos RI, Hammarstrom P, Nilsson KP, Yoshinaga T, Nagamatsu K, Yazaki M, Kametani F, Ikeda SI.
  • Journal Title: Peripher Nerv Syst Volume: 20 Issue: 4 Pages: 372-379
  • DOI: 10.1111/jns.12143
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] An adolscent case of citrin deficiency with severe anorexia mimicking anorexia nervosa (2015)
  • Author(s): Takeuchi S, Yazaki M, Yamada S, Fukuyama T, Inui A, Iwasaki Y, Ikeda S.
  • Journal Title: Pediatrics Volume: 136 Issue: 2 Pages: e530-e534
  • DOI: 10.1542/peds.2014-4172
  • Peer Reviewed
• [Journal Article] The first pure form of Ostertag-type amyloidosis in Japan: a sporadic case of hereditary fibrinogen Aα-chain amyloidosis associated with a novel frameshift variant (2015)
  • Author(s): Yazaki M, Yoshinaga T, Sekijima Y, Nishio S, Kanizawa Y, Kametani F, Miyashita K, Hachiya N, Higuchi K, Ikeda SI.
  • Journal Title: Amyloid Volume: 22 Issue: 2 Pages: 142-144
  • DOI: 10.3109/13506129.2015.1037389
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever. (2015)
  • Author(s): Yasunami M, Nakamura H, Nakamura A, Yazaki M, Kishida D et al.
  • Journal Title: PLoS One Volume: May 14;10(5) Issue: 5 Pages: e0125938-e0125938
  • DOI: 10.1371/journal.pone.0125938
  • NAID: 120007100158
  • Peer Reviewed / Open Access
• [Journal Article] Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondria glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency. (2015)
  • Author(s): Moriyama M, Fujimoto Y, Rikimaru S,Ushikai M, Kuroda E, Kawabe K, Takano K,Asakawa A, Inui A, Eto K, Kadowaki T, Sinasac DS, Okano Y, Yazaki M, Ikeda SI,Zhang C, Song YZ,Sakamoto O, Kure S, Mitsubuchi H, Endo F, Horiuchi M, Nakamura Y, Yamamura KI, Saheki T.
  • Journal Title: Biochim Biophys Acta. Volume: 印刷中 Issue: 9 Pages: 1787-1795
  • DOI: 10.1016/j.bbadis.2015.04.023
  • Peer Reviewed / Open Access
• [Journal Article] Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARalpha (2015)
  • Author(s): Komatsu M, Kimura T, Yazaki M, Tanaka N, Yang Y, Nakajima T, Horiuchi A, Fang ZZ, Joshita S, Matsumoto A, Umemura T, Tanaka E, Gonzalez FJ, Ikeda S, Aoyama T
  • Journal Title: Biochim Biophys Acta Volume: 1852 Issue: 3 Pages: 473-481
  • DOI: 10.1016/j.bbadis.2014.12.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Case of adult-onset type II citrullinemia treated as schizophrenia for a long time. (2015)
  • Author(s): Kyo M, Mii H, Takekita Y, Tokuhara D, Yazaki M, Nakamori Y, Kono S, Kinoshita T.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 69 Issue: 5 Pages: 306-307
  • DOI: 10.1111/pcn.12253
  • Peer Reviewed
• [Journal Article] アミロイドーシスと神経疾患 (2015)
  • Author(s): 矢崎正英
  • Journal Title: BIO Clinica Volume: 30 Pages: 82-85
• [Journal Article] The first pure form of Ostertag type amyloidosis in Japan: a sporadic case of hereditary fibrinogen Aa-chain amyloidosis associated with a novel frameshift variant (2015)
  • Author(s): Yazaki M, Yoshinaga T, Sekijima Y, Nishio S, Kanizawa Y, Kametani F, Miyashita K, Hachiya N, Higuchi K, Ikeda S.
  • Journal Title: Amyloid Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An adolescent case of citrin deficiency with severe anorexia mimicking anorexia nervosa. (2015)
  • Author(s): Takeuchi S, Yazaki M, Yamada S, Fukuyama T, Inui A, Iwasaki Y, Ikeda S.
  • Journal Title: Pediatrics Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Identification of disease-promoting HLA class I and protective class II modifiers in the Japanese patients with familial Mediterranean fever. (2015)
  • Author(s): Yasunami M, Nakamura H, Agematsu K, Nakamura A, Yazaki M, Kishida D, Yachie A, Toma T, Masumoto J, Ida H, Koga T, Kawakami A, Eguchi K, Furukawa H, Nakamura T, Nakaumura M, Migita K.
  • Journal Title: PLOS ONE Volume: 印刷中
  • NAID: 120007100158
  • Peer Reviewed
• [Journal Article] Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse: urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency (2015)
  • Author(s): Moriyama M, Fujimoto Y, Rikimaru S, Ushikai M, Kuroda E, Kawabe K, Takano K, Asakawa A, Inui A, Eto K, Kadowaki T, Sinasac DS, Okano Y, Yazaki M, Ikeda S, Zhang C, Song YZ, Sakamoto O, Kure S, Mitsubuchi H, Endo F, Horiuchi M, Nakamura Y, Yamamura K, Saheki T.
  • Journal Title: Biochim Biophys Acta. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] IL-18 serum concentration is markedly elevated in typical familial Mediterranean fever with M694I mutation and can distinguish it from atypical type. (2015)
  • Author(s): Yamazaki T, Shigemura T, Kobayashi N, Honda K, Yazaki M, Masumoto J, Migita K, Agematsu K
  • Journal Title: Mod Rheumatol. Volume: Epub ahead of print Issue: 4 Pages: 1-4
  • DOI: 10.3109/14397595.2014.908810
  • Peer Reviewed
• [Journal Article] Successful treatment with humanized anti-interleukin-6 receptor antibody (tocilizumab) in a case of AA amyloidosis complicated by familial Mediterranean fever. (2015)
  • Author(s): Hamanoue S, Suwabe T, Hoshino J, Sumida K, Mise K, Hayami N, Sawa N, Takaichi K, Fujii T, Ohashi K, Yazaki M, Ikeda S, Ubara Y.
  • Journal Title: Mod Rheumatol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Autosomal recessive complicated spastic paraplegia with a novel lysosomal trafficking regulator gene mutation. (2014)
  • Author(s): Shimazaki H, et al.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 85 Issue: 9 Pages: 1-5
  • DOI: 10.1136/jnnp-2013-306981
  • Peer Reviewed
• [Journal Article] Familial Mediterranean fever: genotype-phenotype correlations in Japanese patients. (2014)
  • Author(s): Migita K, Agematsu K, Yazaki M, Nonaka F, Nakamura A, Toma T, Kishida D, Uehara R, Nakamura Y, Jiuchi Y, Masumoto J, Furukawa H, Ida H, Terai C, Nakashima Y, Kawakami A, Nakamura T, Eguchi K, Yasunami M, Yachie A.
  • Journal Title: Medicine (Baltimore) Volume: 93 Issue: 3 Pages: 158-164
  • DOI: 10.1097/md.0000000000000029
  • Peer Reviewed
• [Journal Article] An Abnormal MRI Signal in Both Lateral Geniculate Bodies Is a Diagnostic Indicator for Patients with Behçet's Disease. (2014)
  • Author(s): Ogawa Y, Nakagawa M, Yazaki M, Ikeda S, Shu S
  • Journal Title: Case Rep Neurol. Volume: 6 Issue: 1 Pages: 78-82
  • DOI: 10.1159/000360848
  • Peer Reviewed
• [Journal Article] Genotype-phenotype correlation in Japanese patients with familial Mediterranean fever: differences in genotype and clinical features between Japanese and Mediterranean populations. (2014)
  • Author(s): Kishida D, Nakamura A, Yazaki M, Tsuchiya-Suzuki A, Matsuda M, Ikeda S.
  • Journal Title: Arthritis Res Ther. Volume: 16 Issue: 5 Pages: 439-439
  • DOI: 10.1186/s13075-014-0439-7
  • Peer Reviewed / Open Access
• [Journal Article] フィンランド型家族性アミロイドポリニューロパチー -全身臓器病変- (2014)
  • Author(s): 矢崎正英
  • Journal Title: 神経内科 Volume: 81 Pages: 102-106
• [Journal Article] Heavy chain アミロイドーシスの診断と治療 (2014)
  • Author(s): 矢崎正英
  • Journal Title: 腎と透析 Volume: 77 Pages: 159-163
• [Journal Article] アミノ酸代謝異常 シトリン欠損症-成人型シトルリン血症 (2014)
  • Author(s): 矢崎正英、池田修一
  • Journal Title: 別冊日本臨牀 Volume: 28 Pages: 610-614
• [Journal Article] アミロイドとは (2014)
  • Author(s): 矢崎正英、池田修一
  • Journal Title: BRAIN and NERVE Volume: 66 Pages: 723-730
• [Journal Article] 老人性全身性アミロイドーシス (2014)
  • Author(s): 矢崎正英、樋口京一
  • Journal Title: BRAIN and NERVE Volume: 66 Pages: 817-826
• [Journal Article] 肝・腎・肺疾患 肝疾患 シトルリン血症 (2014)
  • Author(s): 矢崎正英、池田修一
  • Journal Title: 別冊日本臨牀 Volume: 30 Pages: 360-364
• [Journal Article] p.E66Q Mutation in the GLA Gene is Associated with a High Risk of Cerebral Small-Vessel Occlusion in Elderly Japanese Males (2014)
  • Author(s): Nakamura K, Sekijima Y, NakamuraK, Hattori K, Nagamatsu K, Shimizu Y, Yazaki M, Sakurai A, Endo F, Fukushima Y, Ikeda S
  • Journal Title: Eur J Neurol Volume: 21 Issue: 1 Pages: 49-56
  • DOI: 10.1111/ene.12214
  • Peer Reviewed
• [Journal Article] Steady turnover of amyloid fibril proteins in gastric mucosa after liver transplantation in familial amyloid polyneuropathy (2013)
  • Author(s): Tsuchiya-Suzuki A, Yazaki M, Sekijima Y, Kametani F, Ikeda S
  • Journal Title: Amyloid Volume: 20 Issue: 3 Pages: 156-163
  • DOI: 10.3109/13506129.2013.807790
  • Peer Reviewed
• [Journal Article] Synovial deposition of wild-type transthyretin-derived amyloid in knee joint osteoarthritis patients (2013)
  • Author(s): Takanashi T, Matsuda M, Yazaki M, Yamazaki H, Nawata M, Katagiri Y, Ikeda S
  • Journal Title: Amyloid Volume: 20 Issue: 3 Pages: 151-155
  • DOI: 10.3109/13506129.2013.803190
  • Peer Reviewed
• [Journal Article] Patient with adult-onset type II citrullinemia beginning 2 years after operation for duodenal malignant somatostatinoma: Indication for liver transplantation (2013)
  • Author(s): Tazawa K, Yazaki M, Fukushima K, Ogata S, Makuuchi M, Morita K, Hiraishi H, Iwasaki Y, Kita J, Kubota K, Ikeda S
  • Journal Title: Hepatol Res Volume: 43 Issue: 5 Pages: 563-568
  • DOI: 10.1111/j.1872-034x.2012.01098.x
  • NAID: 10031183490
  • Peer Reviewed
• [Journal Article] A 73-year-old patient with adult-onset type II citrullinemia successfully treated by sodium pyruvate and arginine. (2013)
  • Author(s): Yazaki M, Kinoshita M, Ogawa S, Fujimi S, Matsushima A, Hineno A, Tazawa K, Fukushima K, Kimura R, Yanagida M, Matsunaga H, Saheki T, Ikeda S.
  • Journal Title: Clin Neurol Neurosurg. Volume: 115 Issue: 8 Pages: 1542-1545
  • DOI: 10.1016/j.clineuro.2012.12.027
  • Peer Reviewed
• [Presentation] 成人発症ＩＩ型シトルリン血症の分子病態、診断、治療 (2015)
  • Author(s): 矢﨑正英
  • Organizer: 第20回日本神経精神医学会
  • Place of Presentation: 石川県立音楽堂（金沢市）
  • Year and Date: 2015-12-11
  • Invited
• [Presentation] 精神症状を主徴とする成人発症ＩＩ型シトルリン血症 (2015)
  • Author(s): 許全利、矢﨑正英、（他6名）
  • Organizer: 第20回日本神経精神医学会
  • Place of Presentation: 石川県立音楽堂（金沢市）
  • Year and Date: 2015-12-11
  • Invited
• [Presentation] 交通外傷後に脳表ヘモジデリン沈着症と多髄節性筋萎縮症を発症した53歳男性例 (2015)
  • Author(s): 高橋佑介、木下朋実、岸田大、矢崎正英、関島良樹、池田修一
  • Organizer: 第215回日本神経学会関東・甲信越地方会
  • Place of Presentation: 砂防会館（東京）
  • Year and Date: 2015-12-05
• [Presentation] Laser microdissectionを用いたアミロイドーシス病型診断の有効性と病早期のアミロイド線維形成機序の解明 (2015)
  • Author(s): 矢崎 正英、亀谷 富由樹、八谷 如美、池田 修一
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-11-30
• [Presentation] 月経周期と一致して発熱を繰り返した家族性地中海熱(FMF)に対して、ジエノゲストが著効した1例 (2015)
  • Author(s): 若林佳奈、小林秀樹, 丸山周作, 橘 賢廣, 森田岳宏, 高橋 済、岡 賢二、矢崎正英
  • Organizer: 第137回内科学会信越地方会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-10-10
• [Presentation] 異常行動出現が診断の契機となった成人型シトルリン血症の65歳女性例 (2015)
  • Author(s): 田部井彬史、佐藤正行、水島和幸、針谷康夫、矢崎正英
  • Organizer: 第214回日本神経学会関東・甲信越地方会
  • Place of Presentation: 砂防会館（東京）
  • Year and Date: 2015-09-05
• [Presentation] Laser microdissection-LC-MS/MSを用いたプロテオーム解析による アミロイドーシス病型診断の有効性と分子病態解析への応用 (2015)
  • Author(s): 矢崎正英、吉長恒明、関島良樹、亀谷富由樹、八谷如美、池田修一
  • Organizer: 第3回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2015-08-21
  • Invited
• [Presentation] 肝移植後遺伝性ATTRアミロイドーシス患者における 脳アミロイドアンギオパチー (2015)
  • Author(s): 関島良樹、矢崎正英、小口和浩、吉長恒明、東城加奈、池田修一
  • Organizer: 第3回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2015-08-21
• [Presentation] Laser microdissection（LMD）を用いて診断した 本邦初のFibrinogen型アミロイドーシスの一例 (2015)
  • Author(s): 吉長恒明、矢崎正英、関島良樹、亀谷富由樹、西尾妙織、蟹沢祐司、奥村伸生、池田修一
  • Organizer: 第3回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2015-08-21
• [Presentation] 各種アミロイドタンパク質沈着組織のレーザーマイクロ ダイセクションおよび質量分析を用いたプロテオミクス解析 (2015)
  • Author(s): 亀谷富由樹、吉長恒明、鈴木彩子、関島良樹、矢崎正英、池田修一
  • Organizer: 第3回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2015-08-21
• [Presentation] 免疫染色で同定困難な断片化免疫グロブリン重鎖による 腎AHアミロイドーシスの1例 (2015)
  • Author(s): 眞部俊、中野麻里絵、藤井照大、亀谷富由樹、矢崎正英、池田修一、長田道夫、波多野道康
  • Organizer: 第3回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2015-08-21
• [Presentation] 原発性マクログロブリン血症に合併した重鎖軽鎖アミロイド－シスの1例 (2015)
  • Author(s): 岩崎千尋、中野麻里絵、藤井照大、眞鍋俊、平澤晃、吉長恒明、矢崎正英、池田修一、亀谷富由樹、波多野道康
  • Organizer: 第3回日本アミロイドーシス研究会 学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2015-08-21
• [Presentation] 自験例ドミノ肝移植レシピエントにおける医原性アミロイドーシスの臨床病理学的検討 (2015)
  • Author(s): 吉長恒明、矢﨑正英、関島良樹、三田篤義、池上俊彦、宮川眞一、池田修一
  • Organizer: 第33回日本肝移植研究会
  • Place of Presentation: ホテルオークラ神戸（神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 成人型シトルリン血症の臨床像と治療戦略：低炭水化物食と薬物治療法の開発 (2015)
  • Author(s): 矢﨑正英
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-05-20
  • Invited
• [Presentation] ドミノ肝移植レシピエントに おけるde novo amyloidosis（医原性FAP） (2015)
  • Author(s): 矢﨑正英、他6名
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-05-20
• [Presentation] 家族性アミロイドポリニューロパチー(FAP)に対する肝移植54例の治療評価 (2015)
  • Author(s): 鈴木 彩子、矢﨑正英、武井洋一、関島良樹、池田修一
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-05-20
• [Presentation] 本邦における家族性地中海熱の臨床像と遺伝学的特徴 (2015)
  • Author(s): 岸田大、中村昭則、矢﨑正英、鈴木彩子、上野賢一、下島恭弘、石井亘、松田正之、池田修一
  • Organizer: 第59回日本リウマチ学会総会・学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-04-23
• [Presentation] 本邦における遺伝性腎アミロイドーシスの分子病態 (2015)
  • Author(s): 矢﨑正英、吉長恒明、関島良樹、西尾妙織、山中修一郎、池田修一
  • Organizer: 第112回日本内科学会総会
  • Place of Presentation: みやこめっせ（京都市）
  • Year and Date: 2015-04-10
• [Presentation] アミロイドーシスの確実な病型診断法の確立と 早期診断の臨床医学的重要性 (2015)
  • Author(s): 矢崎正英
  • Organizer: 第一回ダイレクトバイオロジー研究会
  • Place of Presentation: 東京都産業技術研究センター（東京）
  • Year and Date: 2015-02-13
• [Presentation] 成人発症 II 型シトルリン血症の臨床像と治療について：自験例のまとめ (2014)
  • Author(s): 矢﨑 正英
  • Organizer: 第12回アジア先天代謝異常症シンポジウム
  • Place of Presentation: 江陽グランドホテル（仙台）
  • Year and Date: 2014-11-13 – 2014-11-15
  • Invited
• [Presentation] 成人型シトルリン血症CTLN2の中国人2症例報告 (2014)
  • Author(s): 張春花、王泰齢、趙新顔、矢崎正英、佐伯武賴
  • Organizer: 第12回アジア先天代謝異常症シンポジウム
  • Place of Presentation: 江陽グランドホテル（仙台）
  • Year and Date: 2014-11-13 – 2014-11-15
• [Presentation] シトリン欠損症新規病態マーカーとしてのグリセロール (2014)
  • Author(s): 藤本侑希、矢崎正英、岡野善行、張春花、坂本修、三渕浩、山村研一、佐伯武賴、Yuan-Zong Song、遠藤文夫
  • Organizer: 第12回アジア先天代謝異常症シンポジウム
  • Place of Presentation: 江陽グランドホテル（仙台）
  • Year and Date: 2014-11-13 – 2014-11-15
• [Presentation] ドミノ肝移植後1年でde novo TTR amyloid沈着を認めた66歳女性例 (2014)
  • Author(s): 吉長恒明、矢崎正英、関島良樹、菅原寧彦、田中智弘、池田修一
  • Organizer: 第2回日本アミロイドーシス研究会学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2014-08-22
• [Presentation] アミロイド心筋症を有する肝移植後FAP患者に対するジフルニサルの治療効果の検討 (2014)
  • Author(s): 関島良樹、吉長恒明、矢崎正英、小山潤、池田修一
  • Organizer: 第2回日本アミロイドーシス研究会学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2014-08-22
• [Presentation] 各種アミロイドタンパク質に付随するタンパク質の解析 (2014)
  • Author(s): 亀谷富由樹、吉長恒明、鈴木彩子、矢崎正英、池田修一
  • Organizer: 第2回日本アミロイドーシス研究会学術集会
  • Place of Presentation: KKRホテル（東京）
  • Year and Date: 2014-08-22
• [Presentation] 生体肝移植後18年経過後グラフト不全で死亡した成人型シトルリン血症患者の一剖検例 (2014)
  • Author(s): 矢﨑正英、高曽根健、小林千夏、池田修一、増田雄一、大野康成、三田篤義、池上俊彦、宮川眞一、小松通治、大月聡明
  • Organizer: 第32回日本肝移植研究会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2014-07-03 – 2014-07-04
• [Presentation] Clinical pictures and therapeutic strategy of patients with adult onset type Ⅱ citrullinemia（CTLN2） (2014)
  • Author(s): Masahide Yazaki、Takeyori Saheki
  • Organizer: International Symposium of Citrin Deficiency
  • Place of Presentation: Jinan University, China
  • Year and Date: 2014-06-06 – 2014-06-08
  • Invited
• [Presentation] 成人型シトルリン血症患者の内科的治療戦略：低炭水化物食と経ロピルビン酸の有効性 (2014)
  • Author(s): 矢崎 正英、福島 和広、池田 修一、佐伯 武頼
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡国際センター（福岡）
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] A clinicopathological and long-term follow-up study of AH amyloidosis patients in Japan (2014)
  • Author(s): Yazaki M, Katoh N, Yoshinaga T, Ueno A, Kametani F, Ikeda S
  • Organizer: The XIVth International Symposium on Amyloidosis
  • Place of Presentation: Indianapolis, USA
  • Year and Date: 2014-04-27 – 2014-05-01
• [Presentation] Clinical and endoscopic features of localized immunoglobulin light chain (AL) amyloidosis in the gastrointestinal tract. (2014)
  • Author(s): Katoh N, Yazaki M, Matsuda M, Ikeda S
  • Organizer: The XIVth International Symposium on Amyloidosis
  • Place of Presentation: Indianapolis, USA
  • Year and Date: 2014-04-27 – 2014-05-01
• [Presentation] Safety and efficacy of long-term diflunisal administration in familial amyloid polyneuropathy - Summary of ten years therapeutic experience (2014)
  • Author(s): Sekijima Y, Tojo K, Morita H, Koyama J, Yazaki M, Ikeda S
  • Organizer: The XIVth International Symposium on Amyloidosis
  • Place of Presentation: Indianapolis, USA
  • Year and Date: 2014-04-27 – 2014-05-01
• [Presentation] Regression of gastroduodenal mucosal amyloid deposits in FAP patients after combined therapy with oral intake of diflunisal followed by liver transplantation. (2014)
  • Author(s): Yoshinaga T, Yazaki M, Sekijima Y, Kametani F, Ikeda S
  • Organizer: The XIVth International Symposium on Amyloidosis
  • Place of Presentation: Indianapolis, USA
  • Year and Date: 2014-04-27 – 2014-05-01
• [Presentation] 家族性地中海熱（FMF）の病型と遺伝子変異型の関連 (2014)
  • Author(s): 右田清志、上松一永、和泉泰衛、川原知瑛子、矢崎正英、岸田大、古川宏、寺井千尋、野中文陽、中村正、井田弘明、川上純、江口勝美、谷内江昭宏
  • Organizer: 題58回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪 (東京)
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Therapeutic strategy for patients with adult onset type II citrullinemia (CTLN2) (2013)
  • Author(s): Yazaki M, Fukushima K, Saheki T, Ikeda S
  • Organizer: The 3rd Asian Congress for Inherited Metabolic Diseases
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート（千葉県浦安市）
• [Presentation] 生体肝移植後15年で死亡した家族性アミロイドポリニューロパチー患者のアミロイド沈着動態 (2013)
  • Author(s): 矢崎正英、池田修一
  • Organizer: 第31回日本肝移植研究会
  • Place of Presentation: 熊本全日空ホテルニュースカイ（熊本県熊本市）
• [Presentation] Steady amyloid turn-over after liver transplantation in FAP patients (2013)
  • Author(s): Yazaki M, Tsuchiya-Suzuki A, Sekijima Y, Kametani F, Ikeda S
  • Organizer: IXth International symposium on Familial Amyloidotic Polyneuropathy
  • Place of Presentation: Federal University of Rio deJaneiro（Rio de Janeiro, Brazil）
• [Presentation] 本邦における家族性地中海熱の臨床像ーMEFV遺伝子変異と表現型の関連 (2013)
  • Author(s): 岸田大、鈴木彩子、矢崎正英、中村昭則、松田正之、池田修一
  • Organizer: 第110回日本内科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区）
• [Presentation] AHアミロイドーシスの診断と治療
  • Author(s): 矢崎正英、池田修一、亀谷富由樹
  • Organizer: 第1回日本アミロイドーシス研究会
  • Place of Presentation: KKRホテル東京(東京都千代田区）
• [Presentation] 生体肝移植長期経過(15年)後死亡した家族性アミロイドポリニューロパチー患者の一例ー病理組織像とアミロイド蛋白の解析
  • Author(s): 矢崎正英、加藤修一、池田修一
  • Organizer: 第1回日本アミロイドーシス研究会
  • Place of Presentation: KKRホテル東京(東京都千代田区）
• [Book] EBMに基づく脳神経疾患の基本治療指針 (2016)
  • Author(s): 矢崎正英、池田修一
  • Publisher: ㈱ﾒｼﾞｶﾙﾋﾞｭｰ社,東京
• [Book] AHアミロイドーシス (2014)
  • Author(s): 矢崎正英
  • Publisher: 医薬ジャーナル