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Elucidation of the pathogenesis and development of novel therapies in immune-mediated autonomic neuropathies

Research Project

Project/Area Number 25461276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

Koike Haruki  名古屋大学, 医学(系)研究科(研究院), 准教授 (80378174)

Co-Investigator(Kenkyū-buntansha) IIJIMA Masahiro  名古屋大学, 医学系研究科, 寄附講座講師 (40437041)
SOBUE Gen  名古屋大学, 大学院医学系研究科, 特任教授 (20148315)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords自律神経ニューロパチー / 自己免疫性自律神経節障害 / 急性自律神経性感覚性ニューロパチー / 免疫性自律神経ニューロパチー / 急性自律性神経感覚性ニューロパチー / ギランバレー症候群 / 急性自律性感覚性ニューロパチー / 急性自律性感覚性運動性ニューロパチー / ニューロパチー
Outline of Final Research Achievements

From the point of view of the autonomic neuropathy, at least three subgroups have been proposed on the basis of the concomitance or absence of sensory or motor dysfunctions: 1. pure autonomic neuropathy, 2. autonomic neuropathy with sensory impairment, and 3. autonomic neuropathy with sensory and motor impairment. Some of the patients with pure autonomic neuropathy had slow progression mimicking neurodegenerative diseases. Pathological findings indicated neuronopathy of the autonomic ganglia in patients with pure autonomic neuropathy, while both autonomic and sensory ganglia were affected in patients with sensory impairment. Intravenous immunoglobulin, plasma exchange, or steroids alone or in combination were suggested to be effective even in cases with long-standing autonomic neuropathy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (44 results)

All 2016 2015 2014 2013

All Journal Article (29 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Acknowledgement Compliant: 9 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Book (6 results)

  • [Journal Article] Clinicopathologic features of folate-deficiency neuropathy.2015

    • Author(s)
      Koike H, Takahashi M, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Katsuno M, Doi H, Tanaka F, Sobue G.
    • Journal Title

      Neurology

      Volume: 84 Issue: 10 Pages: 1026-1033

    • DOI

      10.1212/wnl.0000000000001343

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): A multicenter, double-blind trial2015

    • Author(s)
      Koike H, Akiyama K, Saito T, Sobue G
    • Journal Title

      J Neurol

      Volume: 262 Issue: 3 Pages: 752-9

    • DOI

      10.1007/s00415-014-7618-y

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 急性自律性感覚性ニューロパチー2015

    • Author(s)
      小池春樹
    • Journal Title

      日本臨床

      Volume: 73 増刊7 Pages: 452-457

    • Related Report
      2015 Annual Research Report
  • [Journal Article] アミロイドニューロパチー2015

    • Author(s)
      小池春樹、 祖父江元
    • Journal Title

      Peripheral Nerve

      Volume: 26 Pages: 15-24

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 急性感覚性ニューロパチーと急性自律神経ニューロパチー2015

    • Author(s)
      小池春樹
    • Journal Title

      BRAIN and NERVE: 神経研究の進歩

      Volume: 67 Pages: 1377-1387

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 血管炎の新しい分類と基本的な考え方 – 中枢神経血管炎の位置づけ2015

    • Author(s)
      小池春樹、 祖父江元
    • Journal Title

      BRAIN and NERVE: 神経研究の進歩

      Volume: 67 Pages: 243-248

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 傍腫瘍性ニューロパチー2015

    • Author(s)
      大山健、 小池春樹、 祖父江元
    • Journal Title

      日本臨床

      Volume: 73 増刊7 Pages: 782-787

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 抗MAG抗体陽性ニューロパチー2015

    • Author(s)
      川頭祐一、 小池春樹、 祖父江元
    • Journal Title

      日本臨床

      Volume: 73 増刊7 Pages: 440-445

    • Related Report
      2015 Annual Research Report
  • [Journal Article] インフルエンザ感染を契機にFisher症候群の急激な症候悪化を呈したCIDPの1例2015

    • Author(s)
      両角佐織、 安井敬三、 長谷川康博、 小池春樹、 祖父江元
    • Journal Title

      Peripheral Nerve

      Volume: 26 Pages: 93-97

    • Related Report
      2015 Annual Research Report
  • [Journal Article] IgM M蛋白血症を伴うニューロパチー2015

    • Author(s)
      川頭祐一、 小池春樹
    • Journal Title

      医学のあゆみ

      Volume: 255 Pages: 539-542

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ステロイド治療が有効であったサイトメガロウィルス感染後の急性運動・感覚・自律神経ニューロパチーの1例2015

    • Author(s)
      打田祐人、 小池春樹、小栗卓也、加藤秀樹、湯浅浩之、三竹重久
    • Journal Title

      臨床神経学

      Volume: 55 Pages: 339-344

    • NAID

      130005073106

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 脱髄性ニューロパチーランビエ絞輪部における分子病態2015

    • Author(s)
      川頭祐一、 小池春樹、 祖父江元
    • Journal Title

      Annual Review神経

      Volume: 2015 Pages: 219-225

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy2015

    • Author(s)
      Maeshima S, Koike H, Noda S, Noda T, Nakanishi H, Iijima M, Ito M, Kimura S, Sobue G
    • Journal Title

      J Neurol

      Volume: 262 Issue: 4 Pages: 1035-45

    • DOI

      10.1007/s00415-015-7680-0

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Axonal loss influences the response to rituximab treatment in neuropathy associated with IgM monoclonal gammopathy with anti-myelin-associated glycoprotein antibody2015

    • Author(s)
      Kawagashira Y, Koike H, Ohyama K, Hashimoto R, Iijima M, Adachi H, Katsuno M, Chapman M, Lunn M, Sobue G
    • Journal Title

      J Neurol Sci

      Volume: 348 Issue: 1-2 Pages: 67-73

    • DOI

      10.1016/j.jns.2014.11.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Efficacy of intravenous immunoglobulin for treatment of Lambert-Eaton myasthenic syndrome without anti-presynaptic P/Q-type voltage-gated calcium channel antibodies: A case report2015

    • Author(s)
      Okada A, Koike H, Nakamura T, Motomura M, Sobue G
    • Journal Title

      Neuromuscul Disord

      Volume: 25 Issue: 1 Pages: 70-2

    • DOI

      10.1016/j.nmd.2014.08.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] What is the prototype of familial amyloid polyneuropathy?2014

    • Author(s)
      Koike H, Sobue G
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 85 Issue: 7 Pages: 713-713

    • DOI

      10.1136/jnnp-2013-306241

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Muscle atrophy in chronic inflammatory demyelinating polyneuropathy: a computed tomography assessment2014

    • Author(s)
      Ohyama K, Koike H, Katsuno M, Takahashi M, Hashimoto R, Kawagashira Y, Iijima M, Adachi H, Watanabe H, Sobue G
    • Journal Title

      Eur J Neurol

      Volume: 21 Issue: 7 Pages: 1002-10

    • DOI

      10.1111/ene.12426

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Slowly progressive folate-deficiency myelopathy: Report of a case2014

    • Author(s)
      Okada A, Koike H, Nakamura T, Watanabe H, Sobue G
    • Journal Title

      J Neurol Sci

      Volume: 336 Issue: 1-2 Pages: 273-5

    • DOI

      10.1016/j.jns.2013.10.032

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mononeuritis multiplex with tumefactive cellular infiltration in a patient with reactive lymphoid hyperplasia with increased immunoglobulin G4-positive cells2014

    • Author(s)
      Yokoi S, Kawagashira Y, Ohyama K, Iijima M, Koike H, Watanabe H, Tatematsu A, Nakamura S, Sobue G
    • Journal Title

      Hum Pathol

      Volume: 45 Issue: 2 Pages: 427-30

    • DOI

      10.1016/j.humpath.2013.07.047

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cutaneous arteritis associated with peripheral neuropathy: two case reports2014

    • Author(s)
      Riku Y, Ikenaka K, Koike H, Niimi Y, Senda J, Hashimoto R, Kawagashira Y, Tomita M, Iijima M, Sobue G
    • Journal Title

      J Dermatol

      Volume: 41 Issue: 3 Pages: 266-7

    • DOI

      10.1111/1346-8138.12416

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Immunoglobulin G for the Treatment of Chronic Pain: Report of an Expert Workshop2014

    • Author(s)
      Tamburin S, Borg K, Caro XJ, Jann S, Clark AJ, Magrinelli F, Sobue G, Werhagen L, Zanette G, Koike H, Spath PJ, Vincent A, Goebel A
    • Journal Title

      Pain Med

      Volume: 15 Issue: 7 Pages: 1072-82

    • DOI

      10.1111/pme.12319

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuronal intranuclear inclusion disease cases with leukoencephalopathy diagnosed via skin biopsy.2014

    • Author(s)
      Sone J, Kitagawa N, Sugawara E, Iguchi M, Nakamura R, Koike H, Iwasaki Y, Yoshida M, Takahashi T, Chiba S, Katsuno M, Tanaka F, Sobue G
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 85(3) Issue: 3 Pages: 354-356

    • DOI

      10.1136/jnnp-2013-306084

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.2014

    • Author(s)
      Suga N, Katsuno M, Koike H, Banno H, Suzuki K, Hashizume A, Mano T, Iijima M, Kawagashira Y, Hirayama M, Nakamura T, Watanabe H, Tanaka F, Sobue G
    • Journal Title

      Neuropathol Appl Neurobiol.

      Volume: 40 Issue: 5 Pages: 628-639

    • DOI

      10.1111/nan.12055

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differential motor neuron involvement in progressive muscular atrophy: a comparative study with amyotrophic lateral sclerosis2014

    • Author(s)
      Riku Y, Atsuta N, Yoshida M, Tatsumi S, Iwasaki Y, Mimuro M, Watanabe H, Ito M, Senda J, Nakamura R, Koike H, Sobue G
    • Journal Title

      BMJ Open

      Volume: 4 Issue: 5 Pages: e005213-e005213

    • DOI

      10.1136/bmjopen-2014-005213

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autonomic manifestations in acute sensory ataxic neuropathy: a case report.2013

    • Author(s)
      Ohyama K, Koike H, Masuda M, Sone J, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nakamura T, Watanabe H, Sobue G.
    • Journal Title

      Auton Neurosci

      Volume: 179 Issue: 1-2 Pages: 155-158

    • DOI

      10.1016/j.autneu.2013.03.009

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autoimmune autonomic ganglionopathy と acute autonomic and sensory neuropathy2013

    • Author(s)
      小池春樹,祖父江元
    • Journal Title

      臨床神経学

      Volume: 53 Pages: 1326-1329

    • NAID

      130004505433

    • Related Report
      2013 Research-status Report
  • [Journal Article] Differential recovery in cardiac and vasomotor sympathetic functional markers in a patient with acute autonomic sensory and motor neuropathy.2013

    • Author(s)
      Ohyama K, Yasui K, Hasegawa Y, Morozumi S, Koike H, Sobue G.
    • Journal Title

      Intern Med

      Volume: 52 Pages: 497-502

    • NAID

      130003365895

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Wide range of clinicopathological features in immune-mediated autonomic neuropathies.2013

    • Author(s)
      Koike H, Sobue G.
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 4 Pages: 46-59

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features.2013

    • Author(s)
      Koike H, Watanabe H, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 84 Issue: 1 Pages: 98-106

    • DOI

      10.1136/jnnp-2012-302833

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] アミロイドニューロパチー2015

    • Author(s)
      小池春樹
    • Organizer
      第68回日本日本自律神経学会総会
    • Place of Presentation
      愛知県名古屋市 ウインクあいち
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 治療につながる末梢神経病理診断2015

    • Author(s)
      小池春樹
    • Organizer
      第33回日本神経治療学会総会
    • Place of Presentation
      愛知県名古屋市 名古屋国際会議場
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Peripheral neuropathies: from bedside to pathology2015

    • Author(s)
      Koike H
    • Organizer
      52nd Argentine Congress of Neurology
    • Place of Presentation
      Mar del Plata, Argentine
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Acquired neuropathies manifesting small-fiber predominant loss2015

    • Author(s)
      Koike H
    • Organizer
      2nd Argentine Congress of Neurology
    • Place of Presentation
      Mar del Plata, Argentine
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Early- vs. late-onset forms of familial amyloid polyneuropathy2015

    • Author(s)
      Koike H
    • Organizer
      2nd Argentine Congress of Neurology
    • Place of Presentation
      Mar del Plata, Argentine
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 遺伝性圧脆弱性ニューロパチー(HNPP)の臨床病理像と外科治療の試み2015

    • Author(s)
      小池春樹
    • Organizer
      第26回日本末梢神経学会学術集会
    • Place of Presentation
      長野県松本市 ホテルブエナビスタ
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 専門医に必要な末梢神経・筋病理学の素養と利用可能な教育資源,研修機会2015

    • Author(s)
      小池春樹
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟県新潟市 朱鷺メッセ
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] MORPHOLOGY OF NONMYELINATING SCHWANN CELLS IN CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY2014

    • Author(s)
      Haruki Koike, Mie Takahashi, Ken Ohyama, Yuichi Kawagashira, Masahiro Iijima, and Gen Sobue
    • Organizer
      Inflammatory Neuropathy Consortium
    • Place of Presentation
      Hyatt Regency Hotel, Dusseldorf, Germany
    • Year and Date
      2014-07-13 – 2014-07-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Muscle Atrophy in Chronic Inflammatory Demyelinating Polyneuropathy: A Computed Tomography Assessment2014

    • Author(s)
      Ken Ohyama, Haruki Koike, Masahisa Katsuno, Mie Takahashi, Rina Hashimoto, Yuichi Kawagashira, Masahiro Iijima, Hiroaki Adachi, and Gen Sobue
    • Organizer
      Inflammatory Neuropathy Consortium
    • Place of Presentation
      Hyatt Regency Hotel, Dusseldorf, Germany
    • Year and Date
      2014-07-13 – 2014-07-16
    • Related Report
      2014 Research-status Report
  • [Book] 今日の治療指針 20162016

    • Author(s)
      小池春樹、赤水尚史、有賀徹、一瀬雅夫、太田伸生、小澤敬也、金子一成、上條吉人、神田隆、木村正、楠田聡、上阪等、坂部貢、坂本泰二、巽浩一郎、戸倉新樹、永田真、夏目長門、丹生健一、深川雅史ら
    • Total Pages
      2192
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 自律神経機能検査2015

    • Author(s)
      小池春樹、 祖父江元、田村直俊、岩瀬敏、朝比奈正人、榊原隆次、内田さえ、大林光念、小野弓絵、黒澤美枝子、仙波恵美子、谷山紘太郎、原直人、間野忠明、宮本智之、山元敏正、高橋昭、水本結、上山敬司、安東由喜雄ら
    • Total Pages
      508
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report
  • [Book] 免疫症候群(第2版)I2015

    • Author(s)
      小池春樹、 祖父江元、田中正美、市山高志、黒澤和大、藤井敬之、藤田之彦、上田昌美、桑原基、神林隆道、小川剛、竹下幸雄、千葉厚郎、桑原聡、中根俊成、鈴木重明、白石一浩、中村龍文、松永晶子、原誠ら
    • Total Pages
      928
    • Publisher
      日本臨床社
    • Related Report
      2015 Annual Research Report
  • [Book] 今日の診断指針 第7版2015

    • Author(s)
      小池春樹、石塚達夫、平本淳、秋山暢、平家俊男、釜田康行、辻貞俊、桃井眞里子、島津岳士、児玉亘弘、丹羽公一郎、木村守次、五十嵐隆、増山理、藤井秀壯、永井宏和、高田徹、渡辺晋一、宮地良樹、冨山桂昭ら
    • Total Pages
      2144
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 神経疾患最新の治療2015-20172015

    • Author(s)
      小池春樹、 祖父江元、陣上直人、高橋良輔、松本慎一、高尾洋之、村上雄一、鈴木謙介、兵頭明夫、矢坂正弘、小坂憲司、松井真、竹島多賀夫、武田篤、伊藤秀文、松尾秀徳、荒木信夫、伊藤康夫、城倉健、中島健一ら
    • Total Pages
      310
    • Publisher
      南光堂
    • Related Report
      2015 Annual Research Report
  • [Book] Handbook of Clinical Neurology2013

    • Author(s)
      Koike H, Sobue G.
    • Publisher
      Elsevier
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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