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hTFAM improves impaired insulin signaling in Alzheimer's disease

Research Project

Project/Area Number 25461281
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKyushu University

Principal Investigator

OKA SUGAKO  九州大学, 生体防御医学研究所, 研究員 (80467894)

Co-Investigator(Kenkyū-buntansha) KANG DONGCHON  九州大学, 医学系研究院 基礎医学部門, 教授 (80214716)
NAKABEPPU YUSAKU  九州大学, 生体防御医学研究所, 教授 (30180350)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアルツハイマー病 / TFAM / インスリン抵抗性 / 糖尿病 / ミトコンドリア / DNA酸化障害
Outline of Final Research Achievements

Diabetes is known to be a risk factor for Alzheimer’s disease (AD). However, we reported that microarray analysis of the hippocampus of an AD mouse model revealed the altered expression of diabetes-related genes. Moreover, we identified obesity and impaired glucose metabolism in AD model mice of a certain age. This vicious circle is considered to play a pivotal role in the development of AD, but the molecular mechanism remains unclear.
In the present study, we established AD model mice expressing human mitochondrial transcriptional factor A (hTFAM), and found that hTFAM expression effectively ameliorated the AD pathophysiology through the improvement of mitochondrial dysfunction. The expression of hTFAM also improved obesity and glucose tolerance in AD model mice. Our results provide new insights into the molecular mechanisms of the AD pathology, and potential new therapeutic strategies against AD.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) (of which Invited: 2 results)

  • [Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016

    • Author(s)
      Julio, Leon, Sakumi Kunihiko, Castillo Erika, Sheng Zijing, Oka Sugako, Nakabeppu Yusaku.
    • Journal Title

      Scientific Reports

      Volume: 25 Issue: 1 Pages: 22086-22086

    • DOI

      10.1038/srep22086

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death2014

    • Author(s)
      Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y
    • Journal Title

      Oncogenesis

      Volume: 3 Issue: 10 Pages: 1-10

    • DOI

      10.1038/oncsis.2014.35

    • NAID

      120005703608

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitory effects of dietary Spirulina platensis on UVB induced skin inflammatory responses and carcinogenesis.2014

    • Author(s)
      Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y., and Nishigori, C.
    • Journal Title

      J Invest Dermatol

      Volume: N/A Issue: 10 Pages: 2610-2619

    • DOI

      10.1038/jid.2014.188

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered expression of diabetes-related genes in Alzheimer's disease brains: the hisayama study2014

    • Author(s)
      Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y
    • Journal Title

      Cereb Cortex

      Volume: 24 Issue: 9 Pages: 2476-2488

    • DOI

      10.1093/cercor/bht101

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) breaks the vicious circle of oxidative stress and amyloid β accumulation in triple-transgenic mouse model of Alzheimer’s disease2015

    • Author(s)
      Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      第38回日本分子生物学会年会, 第88回日本生化学会 合同大会 (神戸)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2014

    • Author(s)
      Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      The 14th Annual Conference of Japanese Society of Mitochondrial Research and Medicine
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2014

    • Author(s)
      Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease2014

    • Author(s)
      Sugako Oka, Dongchon Kang, Yusaku Nakabeppu
    • Organizer
      第27回変異機構研究会
    • Place of Presentation
      愛知
    • Year and Date
      2014-06-21 – 2014-06-22
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2014

    • Author(s)
      Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      EuroMit International Meeting on Mitochondrial Pathology 2014
    • Place of Presentation
      Finland,
    • Year and Date
      2014-06-15 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice2014

    • Author(s)
      Sugako Oka, Julio Leon, Atsuhisa Katogi, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      EUROMIT2014 International Meeting on Mitochondrial Pathology
    • Place of Presentation
      TAMPERE FINLAND
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice

    • Author(s)
      Sugako Oka1, Julio Leon, Masaaki Hokama, Atsuhisa Katogi1, Kunihiko Sakumi, Tomomi Ide, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      日本 神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice

    • Author(s)
      Sugako Oka, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      Neuro2013
    • Place of Presentation
      日本 京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in Alzheimer’s disease model mice

    • Author(s)
      Sugako Oka, Julio Leon, Masaaki Hokama, Atsuhisa Katogi1, Kunihiko Sakumi, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      日本 東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of human mitochondrial transcriptional factor A (hTFAM) improves cognitive function in a mouse model of Alzheimer’s disease

    • Author(s)
      Sugako Oka, Dongchon Kang and Yusaku Nakabeppu
    • Organizer
      The Alzheimer’s Association International Conference in Boston, United States, 2013.
    • Place of Presentation
      BOSTON USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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