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Glucocerebrosidase associates with membrane trafficking system

Research Project

Project/Area Number 25461290
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionJuntendo University

Principal Investigator

Hatano Taku  順天堂大学, 医学部, 准教授 (60338390)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsParkinson's disease / Glucocerebrosidase / Lipid enzymes / パーキンソン病 / 膜輸送 / 脂質代謝酵素 / Saposin / Lipid raft
Outline of Final Research Achievements

It is well known that the impairment of glucocerebrosidase is associated with not only Gaucher disease, but also Parkinson's disease. This enzyme catalyzes the hydrolysis of glucosylceramide to form cderamide and glucose. Therefor, the impairment of GBA might induce the alteration of membrane composition. I revealed that GBA inhibition might induce the alteration of membrane trafficking and lysosome.
I investigated whether other lysosomal proteins might be associated with PD and found that one of lysosomal associated proteins also causes autosomal dominant familial PD. The impairment of the protein might induce the membrane trafficking perturbation and induce lysosomal dysfunction.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2016 2015 2014 2013

All Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease.2016

    • Author(s)
      Kamagata K, Hatano T, Okuzumi A, Motoi Y, Abe O, Shimoji K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S
    • Journal Title

      European Radiology

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Direct Cost of Parkinson Disease at Juntendo Medical University Hospital, Japan2016

    • Author(s)
      Yoritaka A, Fukae J, Hatano T, Oda E, Hattori N.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 2 Pages: 113-119

    • DOI

      10.2169/internalmedicine.55.4484

    • NAID

      130005119755

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] What is NODDI and what is its role in Parkinson's assessment?2016

    • Author(s)
      Kamagata K, Hatano T, Aoki S.
    • Journal Title

      Expert Rev Neurother

      Volume: 16 Issue: 3 Pages: 241-243

    • DOI

      10.1586/14737175.2016.1142876

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of the Japanese version of the 9-item Wearing-off questionnaire.2015

    • Author(s)
      Fukae J, Higuchi MA, Yanamoto S, Fukuhara K, Tsugawa J, Ouma S, Hatano T, Yoritaka A, Okuma Y, Kahihara K, Hattori N, Tsuboi Y.
    • Journal Title

      Clinical Neurology Neurosurgery

      Volume: 134 Pages: 111-115

    • DOI

      10.1016/j.clineuro.2015.04.021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Re-emergent jaw tremor in Parkinson’s disease.2015

    • Author(s)
      Hatano T, Kurita N, Kobayashi M, Hattori N.
    • Journal Title

      Neurology

      Volume: 85 Issue: 23

    • DOI

      10.1212/wnl.0000000000002189

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Decreased regional cerebral blood flow in the bilateral thalami and medulla oblongata determined by an easy Z-score (eZIS) analysis of (99m)Tc-ECD-SPECT images in a case of MM2-thalamic-type sporadic Creutzfeldt-Jakob disease.2015

    • Author(s)
      Hayashi Y, Iwasaki Y, Yoshikura N, Asano T, Hatano T, Tatsumi S, Satoh K, Kimura A, Kitamoto T, Yoshida M, Inuzuka T.
    • Journal Title

      J Neurol Sci

      Volume: 358 Issue: 1-2 Pages: 447-452

    • DOI

      10.1016/j.jns.2015.09.356

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The prevalence and risk factors of cerebral microbleeds in patients with Parkinson's disease.2015

    • Author(s)
      Yamashiro K, Tanaka R, Hoshino Y, et al.
    • Journal Title

      Parkinsonism Relat Disord.

      Volume: 21 Issue: 9 Pages: 1076-1081

    • DOI

      10.1016/j.parkreldis.2015.06.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Target- and input-dependent organization of AMPA and NMDA receptors in synaptic connections of the cochlear nucleus2015

    • Author(s)
      Rubio ME, Fukazawa Y, Kamasawa N, Clarkson C, Molnar E, Shigemoto R
    • Journal Title

      J Comp Neurol

      Volume: 588 Pages: 29-35

    • DOI

      10.1016/j.neulet.2014.12.052

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipid rafts involvement in the pathogenesis of Parkinso’s disease.2015

    • Author(s)
      Kubo SI, Hatano T, Hattori N.
    • Journal Title

      Front Biosci (Landmark Ed).

      Volume: 20 Pages: 263-279

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sensory tricks for isolated speech-induced lingual dystonia.2015

    • Author(s)
      Shimo Y, Nishina K, Hatano T, Hattori N.
    • Journal Title

      BMJ case reports

      Volume: - Pages: bcr2014208272-bcr2014208272

    • DOI

      10.1136/bcr-2014-208272

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of novel biomarkers for Parkinson's disease by metabolomic technologies.2015

    • Author(s)
      Hatano T, Saiki S, Okuzumi A, Mohney RP, Hattori N.
    • Journal Title

      J Neurol Neurosurg Psychiatry.

      Volume: jnnp-2014 Issue: 3 Pages: 2014-309676

    • DOI

      10.1136/jnnp-2014-309676

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ophthalmic nerve hypertrophy in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.2014

    • Author(s)
      Okuzumi A, Hatano T, Nakahara T, Yokoyama K, Hattori N.
    • Journal Title

      Neurology

      Volume: 82 Issue: 17 Pages: 1566-1567

    • DOI

      10.1212/wnl.0000000000000362

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantitative evaluation of electroconvulsive therapy for Parkinson’s disease with refractory psychiatric symptoms.2014

    • Author(s)
      Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, Arai H, Hattori N, Urabe T.
    • Journal Title

      Journal of Neural Transmission

      Volume: 121 Issue: 11 Pages: 1405-1410

    • DOI

      10.1007/s00702-014-1212-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum uric acid concentration is linked to wearing-off fluctuation in Japanese Parkinson’s disease patients.2014

    • Author(s)
      Fukae J, Ishikawa KI, Hatano T, Yoritaka A, Takanashi M, Shimo Y, Tsugawa J, Tsuboi Y, Hattori N.
    • Journal Title

      Journal of Parkinson Disease

      Volume: 4 Issue: 3 Pages: 499-505

    • DOI

      10.3233/jpd-140353

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rhinorrhea in Parkinson's disease: a consecutive multicenter study in Japan.2014

    • Author(s)
      Kano O, Yoshioka M, Nagayama H, Hamada S, Maeda T, Hasegawa T, Kadowaki T, Sengoku R, Terashi H, Hatano T, Nomoto N, Inoue M, Shimura H, Takahashi T, Uchiyama T, Watanabe H, Kaneko S, Takahashi T, Baba Y, Kubo S; Young Japanese Expert Group for Parkinson's Disease and Movement Disorders: YJ-EXPANDS.
    • Journal Title

      Journal of Neurological Science

      Volume: 343 Issue: 1-2 Pages: 88-90

    • DOI

      10.1016/j.jns.2014.05.039

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease.2014

    • Author(s)
      Hatano T, Funayama M, Kubo S, Mata IF, Oji Y, Mori A, Zabetian CP, Waldherr SM, Yoshino H, Oyama G, Shimo Y, Fujimoto K, Oshima H, Kunii Y, Yabe H, Mizuno Y, Hattori N.
    • Journal Title

      Neurobiol Aging.

      Volume: Nov;35(11) Issue: 11 Pages: 2656.e17-2656.e23

    • DOI

      10.1016/j.neurobiolaging.2014.05.025

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Motor and non-motor symptoms of 1453 patients with Parkinson’s disease: any relationship with the cumulative doses of anti-parkinsonian medications?2014

    • Author(s)
      Yoritaka A, Shimo Y, Takanashi M, Fukae J, Hatano T, Nakahara T, Miyamoto N, Urabe T, Hattori N.
    • Journal Title

      Journal of Neurological Disorders & Stroke

      Volume: 2 Pages: 1042-1042

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] An exploratory study of the efficacy and safety of yokukansan for neuropsychiatric symptoms in patients with Parkinson's disease.2014

    • Author(s)
      Hatano T, Hattori N, Kawanabe T, Terayama Y, Suzuki N, Iwasaki Y, Fujioka T; Yokukansan Parkinson’s Disease Study Group
    • Journal Title

      Journal of Neural Transmission

      Volume: 121 Issue: 3 Pages: 275-281

    • DOI

      10.1007/s00702-013-1105-y

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging.2014

    • Author(s)
      Kamagata K, Tomiyama H, Hatano T, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Yoshida M, Hattori N, Aoki S.
    • Journal Title

      Neuroradiology

      Volume: 56 Issue: 3 Pages: 251-258

    • DOI

      10.1007/s00234-014-1327-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Motor and non-motor symptoms of 1453 patients with Parkinson's disease: prevalence and risks.2013

    • Author(s)
      Yoritaka A, Shimo Y, Takanashi M, Fukae J, Hatano T, Nakahara T, Miyamato N, Urabe T, Mori H, Hattori N
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: 19 Issue: 8 Pages: 725-731

    • DOI

      10.1016/j.parkreldis.2013.04.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Can parkin be a target for future treatment of Parkinson's disease?2013

    • Author(s)
      Kubo S, Hatano T, Takanashi M, Hattori N
    • Journal Title

      Expert Opinion Therapeutic Targets

      Volume: 17 Issue: 10 Pages: 1133-1144

    • DOI

      10.1517/14728222.2013.827173

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lateral and dorsal column hyperintensity on magnetic resonance imaging in a patient with myelopathy associated with intrathecal chemotherapy.2013

    • Author(s)
      Saito F, Hatano T, Hori M, Kawamura M, Sasaki M, Aoki S, Hattori N
    • Journal Title

      Case Report in Neurology

      Volume: 5 Issue: 2 Pages: 110-115

    • DOI

      10.1159/000351848

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] λIdentification of novel biomarkers for Parkinson’s disease by metabolomics technologies.2015

    • Author(s)
      Hatano T, Saiki S, Okuzumi A, Hattori N.
    • Organizer
      International congress of Parkinson’s disease and movement disorders.
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hyposmia might be linked to inferior temporal cortical thickness in Parkinson’s disease2015

    • Author(s)
      Hatano T, Kamagata K, Okuzumi A, Hori M, Takeda A, Aoki S.
    • Organizer
      日本神経学会総会
    • Place of Presentation
      新潟県新潟市
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of novel biomarkers for Parkinson’s disease by metabolomics technologies.2015

    • Author(s)
      Okuzumi A, Hatano T, Saiki S, Hattori N.
    • Organizer
      日本神経学会総会
    • Place of Presentation
      新潟県新潟市
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of a Japanese family with Parkinson’s disease due to the LRRK2 p.R1441G mutation2014

    • Author(s)
      T. Hatano, M. Funayama, S.-I. Kubo, I.F. Mata, Y. Oji, A. Mori, C.P. Zabetian, S. Waldherr, H. Yoshino, G. Oyama, Y. Shimo, K.-I. Fujimoto, H. Oshima, Y. Kunii, H. Yabe, Y. Mizuno, N. Hattori
    • Organizer
      18th International congress of Parkinson’s disease and movement disorders.
    • Place of Presentation
      ストックホルム,スウェーデン
    • Year and Date
      2014-06-08 – 2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Intracellular localization of PLA2G62014

    • Author(s)
      A. Mori, Y. Oji, A. Okuzumi, T. Hatano, S-I. Kubo, N. Hattori.
    • Organizer
      18th International congress of Parkinson’s disease and movement disorders.
    • Place of Presentation
      ストックホルム,スウェーデン
    • Year and Date
      2014-06-08 – 2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Mutant glucocerebrosidase changes its subcellular localization2014

    • Author(s)
      Y. Oji, A. Mori, T. Hatano, S-I. Kubo, N. Hattori
    • Organizer
      18th International congress of Parkinson’s disease and movement disorders.
    • Place of Presentation
      ストックホルム,スウェーデン
    • Year and Date
      2014-06-08 – 2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 本邦におけるLRRK2-R1441G変異に関連したパーキンソン病の臨床的特徴2014

    • Author(s)
      波田野 琢, 舩山 学, 久保 紳一郎, Ignacio Mata, 吉野 浩代, 王子 悠, 森 聡生, 藤本 健一, 大島 洋和, 國井 泰人, 矢部 博興, 水野 美邦, 服部 信孝
    • Organizer
      2014年 第55回 日本神経学会総会 福岡 5月21-24日
    • Place of Presentation
      福岡,福岡国際会議場・福岡サンパレス・福岡国際センター
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] GBA変異によるglucocerebrosidaseの局在変化の検討2014

    • Author(s)
      王子 悠,森 聡生, 波田野 琢, 久保 紳一郎, 服部 信孝
    • Organizer
      2014年 第55回 日本神経学会総会 福岡 5月21-24日
    • Place of Presentation
      福岡,福岡国際会議場・福岡サンパレス・福岡国際センター
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] PLA2G6における細胞内局在の変化および病態の検討2014

    • Author(s)
      森 聡生, 王子 悠, 奥住 文美, 波田野 琢, 久保 紳一郎, 服部 信孝
    • Organizer
      2014年 第55回 日本神経学会総会 福岡 5月21-24日
    • Place of Presentation
      福岡,福岡国際会議場・福岡サンパレス・福岡国際センター
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Levodopa-responsive Parkinsonism following bilateral putaminal hemorrhages2013

    • Author(s)
      Hatano , T., Kubo , S.I., Niijima-Ishii , Y., Sugita , H., Hattori , N
    • Organizer
      MDS 17th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Research-status Report
  • [Presentation] Continuous dopaminergic stimulation (CDS)実現による運動症状への対応2013

    • Author(s)
      波田野 琢
    • Organizer
      日本神経治療学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 神経内科外来シリーズ2 パーキンソン病外来2016

    • Author(s)
      波田野琢 服部信孝
    • Total Pages
      264
    • Publisher
      メジカルビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] Movement Disorders in Neurologic and Systemic Diesase2014

    • Author(s)
      Hatano T, Kubo S. I., Hattori N, Mizuno Y
    • Total Pages
      470
    • Publisher
      Cambridge
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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