Glucocerebrosidase associates with membrane trafficking system
Project/Area Number |
25461290
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Juntendo University |
Principal Investigator |
Hatano Taku 順天堂大学, 医学部, 准教授 (60338390)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | Parkinson's disease / Glucocerebrosidase / Lipid enzymes / パーキンソン病 / 膜輸送 / 脂質代謝酵素 / Saposin / Lipid raft |
Outline of Final Research Achievements |
It is well known that the impairment of glucocerebrosidase is associated with not only Gaucher disease, but also Parkinson's disease. This enzyme catalyzes the hydrolysis of glucosylceramide to form cderamide and glucose. Therefor, the impairment of GBA might induce the alteration of membrane composition. I revealed that GBA inhibition might induce the alteration of membrane trafficking and lysosome. I investigated whether other lysosomal proteins might be associated with PD and found that one of lysosomal associated proteins also causes autosomal dominant familial PD. The impairment of the protein might induce the membrane trafficking perturbation and induce lysosomal dysfunction.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease.2016
Author(s)
Kamagata K, Hatano T, Okuzumi A, Motoi Y, Abe O, Shimoji K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S
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Journal Title
European Radiology
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Utility of the Japanese version of the 9-item Wearing-off questionnaire.2015
Author(s)
Fukae J, Higuchi MA, Yanamoto S, Fukuhara K, Tsugawa J, Ouma S, Hatano T, Yoritaka A, Okuma Y, Kahihara K, Hattori N, Tsuboi Y.
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Journal Title
Clinical Neurology Neurosurgery
Volume: 134
Pages: 111-115
DOI
Related Report
Peer Reviewed
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[Journal Article] Decreased regional cerebral blood flow in the bilateral thalami and medulla oblongata determined by an easy Z-score (eZIS) analysis of (99m)Tc-ECD-SPECT images in a case of MM2-thalamic-type sporadic Creutzfeldt-Jakob disease.2015
Author(s)
Hayashi Y, Iwasaki Y, Yoshikura N, Asano T, Hatano T, Tatsumi S, Satoh K, Kimura A, Kitamoto T, Yoshida M, Inuzuka T.
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Journal Title
J Neurol Sci
Volume: 358
Issue: 1-2
Pages: 447-452
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Rhinorrhea in Parkinson's disease: a consecutive multicenter study in Japan.2014
Author(s)
Kano O, Yoshioka M, Nagayama H, Hamada S, Maeda T, Hasegawa T, Kadowaki T, Sengoku R, Terashi H, Hatano T, Nomoto N, Inoue M, Shimura H, Takahashi T, Uchiyama T, Watanabe H, Kaneko S, Takahashi T, Baba Y, Kubo S; Young Japanese Expert Group for Parkinson's Disease and Movement Disorders: YJ-EXPANDS.
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Journal Title
Journal of Neurological Science
Volume: 343
Issue: 1-2
Pages: 88-90
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease.2014
Author(s)
Hatano T, Funayama M, Kubo S, Mata IF, Oji Y, Mori A, Zabetian CP, Waldherr SM, Yoshino H, Oyama G, Shimo Y, Fujimoto K, Oshima H, Kunii Y, Yabe H, Mizuno Y, Hattori N.
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Journal Title
Neurobiol Aging.
Volume: Nov;35(11)
Issue: 11
Pages: 2656.e17-2656.e23
DOI
Related Report
Peer Reviewed
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[Journal Article] A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging.2014
Author(s)
Kamagata K, Tomiyama H, Hatano T, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Yoshida M, Hattori N, Aoki S.
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Journal Title
Neuroradiology
Volume: 56
Issue: 3
Pages: 251-258
DOI
Related Report
Peer Reviewed
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[Presentation] Identification of a Japanese family with Parkinson’s disease due to the LRRK2 p.R1441G mutation2014
Author(s)
T. Hatano, M. Funayama, S.-I. Kubo, I.F. Mata, Y. Oji, A. Mori, C.P. Zabetian, S. Waldherr, H. Yoshino, G. Oyama, Y. Shimo, K.-I. Fujimoto, H. Oshima, Y. Kunii, H. Yabe, Y. Mizuno, N. Hattori
Organizer
18th International congress of Parkinson’s disease and movement disorders.
Place of Presentation
ストックホルム,スウェーデン
Year and Date
2014-06-08 – 2014-06-12
Related Report
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[Presentation] Intracellular localization of PLA2G62014
Author(s)
A. Mori, Y. Oji, A. Okuzumi, T. Hatano, S-I. Kubo, N. Hattori.
Organizer
18th International congress of Parkinson’s disease and movement disorders.
Place of Presentation
ストックホルム,スウェーデン
Year and Date
2014-06-08 – 2014-06-12
Related Report
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[Presentation] 本邦におけるLRRK2-R1441G変異に関連したパーキンソン病の臨床的特徴2014
Author(s)
波田野 琢, 舩山 学, 久保 紳一郎, Ignacio Mata, 吉野 浩代, 王子 悠, 森 聡生, 藤本 健一, 大島 洋和, 國井 泰人, 矢部 博興, 水野 美邦, 服部 信孝
Organizer
2014年 第55回 日本神経学会総会 福岡 5月21-24日
Place of Presentation
福岡,福岡国際会議場・福岡サンパレス・福岡国際センター
Year and Date
2014-05-21 – 2014-05-24
Related Report
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[Presentation] PLA2G6における細胞内局在の変化および病態の検討2014
Author(s)
森 聡生, 王子 悠, 奥住 文美, 波田野 琢, 久保 紳一郎, 服部 信孝
Organizer
2014年 第55回 日本神経学会総会 福岡 5月21-24日
Place of Presentation
福岡,福岡国際会議場・福岡サンパレス・福岡国際センター
Year and Date
2014-05-21 – 2014-05-24
Related Report
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[Presentation] Levodopa-responsive Parkinsonism following bilateral putaminal hemorrhages2013
Author(s)
Hatano , T., Kubo , S.I., Niijima-Ishii , Y., Sugita , H., Hattori , N
Organizer
MDS 17th International Congress of Parkinson's Disease and Movement Disorders
Place of Presentation
Sydney, Australia
Related Report
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