Analysis of newly identified pathogenic CD4+ helper T-cells in patients with HTLV-1-associated myelopathy

• Project/Area Number: 25461294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: Yamano Yoshihisa 聖マリアンナ医科大学, 医学(系)研究科(研究院), 准教授 (80445882)
• Co-Investigator(Kenkyū-buntansha): MISU Tatsuro 東北大学, 医学(系)研究科(研究院), 助教 (00396491)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 内科系臨床医学 / 神経内科学 / 神経病態免疫学

Outline of Final Research Achievements

The main feature of Human T-lymphotropic virus type I (HTLV-1) -associated myelopathy (HAM) pathogenesis is a virus-induced hyperactive immune response that produces chronic inflammation in the central nervous system (CNS), but the mechanism by which HTLV-1 deregulates the immune response is unknown. We recently reported a high frequency of HTLV-1-infected CCR4+ cells, including regulatory T cells. We showed that HTLV-1 induces a Th1-like state in these CCR4+ cells via T-bet expression. We have also found that CXCL10 plays an important role in a positive feedback loop that maintains inflammation in the CNS. Astrocytes, which were found to be the main producers of CXCL10 in the CNS, are another key player in the loop. In short, we postulate that infected CCR4+ Th1-like T cells produce interferon-γ, which stimulates astrocytes to produce CXCL10. We now have a much better understanding of the molecular mechanisms at play in HAM pathogenesis.

Research Products

• [Journal Article] HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors. (2016)
  • Author(s): Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.
  • Journal Title: J Neurovirol. Volume: in press Issue: 4 Pages: 416-430
  • DOI: 10.1007/s13365-015-0407-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β. (2015)
  • Author(s): Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
  • Journal Title: EMBO J. Volume: 34 Issue: 8 Pages: 1042-55
  • DOI: 10.15252/embj.201489897
  • Peer Reviewed / Open Access
• [Journal Article] Standardization of quantitative PCR for human T-cell leukemia virus type 1 in Japan: A collaborative study (2015)
  • Author(s): Kuramitsu M, Okuma K, Yamochi T. et al
  • Journal Title: J. Clin. Microbien. Volume: 53 Issue: 11 Pages: 3485-3491
  • DOI: 10.1128/jcm.01628-15
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis. (2015)
  • Author(s): Bangham C, Araujo A, Yamano Y & Taylor G.
  • Journal Title: Nature Reviews Disease Primers Volume: 1 Issue: 1
  • DOI: 10.1038/nrdp.2015.12
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antibodies to glycoconjugates in autoimmune neuropathies. (2015)
  • Author(s): Kenichi Kaida
  • Journal Title: Clinical and Experimental Neuroimmunology Volume: 6 Issue: 4 Pages: 387-394
  • DOI: 10.1111/cen3.12256
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 免疫性神経疾患－基礎・臨床研究の最新知見－. (2015)
  • Author(s): 山野嘉久、新谷奈津美、八木下尚子、佐藤知雄.
  • Journal Title: 日本臨牀 Volume: 73（7） Pages: 546-553
• [Journal Article] HTLV-1関連脊髄症（HAM）－分子病態解明による治療薬開発の新展開. (2015)
  • Author(s): 山野嘉久.
  • Journal Title: 医学のあゆみ Volume: 255(5) Pages: 485-490
• [Journal Article] Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy. (2015)
  • Author(s): Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H, Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y.
  • Journal Title: J Infect Dis. Volume: 211 Issue: 2 Pages: 238-48
  • DOI: 10.1093/infdis/jiu438
  • Peer Reviewed / Open Access
• [Journal Article] A plasma diagnostic model of human T cell leukemia virus-1 associated myelopathy. (2015)
  • Author(s): Ishihara M, Araya N, Sato T, Saichi N, Fujii R, Yamano Y, Sugano S, Ueda K.
  • Journal Title: Ann Clin Transl Neurol Volume: 2(3) Issue: 3 Pages: 231-240
  • DOI: 10.1002/acn3.169
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells. (2014)
  • Author(s): Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y.
  • Journal Title: J Clin Invest. Volume: 124 Issue: 8 Pages: 3431-42
  • DOI: 10.1172/jci75250
  • Peer Reviewed / Open Access
• [Journal Article] Neurological involvement of relapsing polychondritis in Japan: An epidemiological study. (2014)
  • Author(s): Suzuki N, Shimizu J, Oka H, Yamano Y, Yudoh K.
  • Journal Title: Inflammation and Regeneration Volume: 34(4) Pages: 206-208
  • NAID: 130004943867
• [Journal Article] Positive feedback loop via astrocytes causes chronic inflammation in human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. (2014)
  • Author(s): Coler-Reilly A, Ando H, Yamano Y.
  • Journal Title: Clinical and Experimental Neuroimmunology Volume: 5 Pages: 108-109
• [Journal Article] A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy. (2014)
  • Author(s): Kawamata T, Ohno N, Sato K, Kobayashi M, Jo N, Yuji K, Tanosaki R, Yamano Y, Tojo A, Uchimaru K.
  • Journal Title: SpringerPlus Volume: 3 Issue: 1 Pages: 581-581
  • DOI: 10.1186/2193-1801-3-581
  • Open Access
• [Journal Article] HTLV-1関連脊髄症（HAM） (2014)
  • Author(s): 山野嘉久
  • Journal Title: 別冊日本臨牀 Volume: 30 Pages: 153-156
  • NAID: 130007905324
• [Journal Article] HTLV-1の神経障害. (2014)
  • Author(s): 山野嘉久.
  • Journal Title: 内科 Volume: 113(6) Pages: 1431-1431
• [Journal Article] HTLV-1関連脊髄症（HAM）の分子病態に基づく治療戦略. (2014)
  • Author(s): 山野嘉久.
  • Journal Title: 細胞 Volume: 46(6) Pages: 258-261
• [Journal Article] HTLV-1関連脊髄症（HAM）に対する分子標的治療薬開発の現状と将来. (2014)
  • Author(s): 新谷奈津美, 山野嘉久.
  • Journal Title: 血液内科 Volume: 68（1） Pages: 30-35
• [Journal Article] 希少な慢性進行性の神経難病HAMにおける治療有効性評価モデルの探索. (2014)
  • Author(s): 山野嘉久.
  • Journal Title: 臨床評価 別冊 Volume: 41(3) Pages: 504-508
• [Journal Article] 気道病変を有する再発性多発軟骨炎に対するチオトロピウムの効果. (2014)
  • Author(s): 半田寛, 薄場彩乃, 岡本真理子, 井上哲兵, 延山誠一, 井上健男, 峯下昌道, 山野嘉久, 宮澤輝臣.
  • Journal Title: 聖マリアンナ医科大学雑誌 Volume: 41(4) Pages: 315-321
• [Journal Article] Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy. (2013)
  • Author(s): Ando H., Sato T., Tomaru U., Yoshida M., Utsunomiya A., Yamauchi J., Araya N., Yagishita N., Coler-Reilly A., Shimizu Y., Yudoh K., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Yamano Y.
  • Journal Title: Brain Volume: 136(Pt9) Issue: 9 Pages: 2876-2887
  • DOI: 10.1093/brain/awt183
  • Peer Reviewed
• [Journal Article] CSF CXCL10, CXCL9, and Neopterin as Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (2013)
  • Author(s): Sato T., Coler-Reilly A., Utsunomiya A., Araya N., Yagishita N., Ando H., Yamauchi J., Inoue E., Ueno T., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Izumo S., Yamano Y.
  • Journal Title: PLoS Negl Trop Dis Volume: 7(10) Issue: 10 Pages: e2479-e2479
  • DOI: 10.1371/journal.pntd.0002479
  • Peer Reviewed
• [Journal Article] Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia (2013)
  • Author(s): Ishihara M., Araya N., Sato T., et al.
  • Journal Title: Blood Volume: in press Issue: 21 Pages: 4340-7
  • DOI: 10.1182/blood-2012-08-446922
  • Peer Reviewed
• [Journal Article] Potential contribution of a novel Taxepitope-specific CD4+ T cells tograftversus-Tax effects in adult T-cell leukemia patients after allogeneichematopoietic stem celltransplantation. (2013)
  • Author(s): Tamai Y., Hasegawa A., Takamori A., et al.
  • Journal Title: Journal of Immunology Volume: in press Issue: 8 Pages: 4382-4392
  • DOI: 10.4049/jimmunol.1202971
  • Peer Reviewed
• [Journal Article] 慢性型ATLの自然寛解後にHTLV-1関連脊髄症を発症した症例. (2013)
  • Author(s): 宇都宮與, 山野嘉久.
  • Journal Title: 血液フロンティア Volume: 23(3) Pages: 5-10
• [Journal Article] Human T-lymphotropic virus type 1感染者における腎移植の影響. (2013)
  • Author(s): 山内淳司、八木下尚子、安藤仁、佐藤知雄、新谷奈津美、Ariella, Coler-Reilly、今井直彦、中澤龍斗、佐々木秀郎、柴垣有吾、安田隆、力石辰也、木村健二郎、山野嘉久.
  • Journal Title: 日本臨床腎移植学会雑誌 Volume: 1(1) Pages: 55-60
  • Peer Reviewed
• [Journal Article] 白血病 非定型白血病および特殊型 HTLV-1関連脊髄症（HAM）. (2013)
  • Author(s): 山野嘉久、佐藤知雄、宇都宮與.
  • Journal Title: 別冊日本臨牀 新領域別症候群シリーズ 血液症候群（第2版） Volume: 23(III) Pages: 195-199
• [Journal Article] HTLV-1関連脊髄症（HAM）の病態・治療とバイオマーカー (2013)
  • Author(s): 山野嘉久、佐藤知雄
  • Journal Title: 日本臨牀 Volume: 71（5） Pages: 870-875
• [Presentation] HAMの病態機序に基づいた疾患修飾薬の開発. (2016)
  • Author(s): 山野嘉久.
  • Organizer: 日沼賴夫先生メモリアルシンポジウムHTLV-1 研究の現況と展望
  • Place of Presentation: 京都府京都市（京都大学芝蘭会館 山内ホール）
  • Year and Date: 2016-03-16
  • Invited
• [Presentation] HAMの治療展望. (2015)
  • Author(s): 山野嘉久.
  • Organizer: 第27回日本神経免疫学会学術集会
  • Place of Presentation: 岐阜県岐阜市（長良川国際会議場）
  • Year and Date: 2015-09-15
  • Invited
• [Presentation] How does HTLV-1 cause CNS disease? - The importance of cross-talk between infected T-cells and astrocytes. (2015)
  • Author(s): Yamano Y.
  • Organizer: The Inaugural Asia-Pacific School of Neuroimmunology Meeting
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2015-08-30
  • Int'l Joint Research / Invited
• [Presentation] HTLV-1関連脊髄症(HAM)における髄液細胞のケモカイン受容体解析. (2015)
  • Author(s): 佐藤知雄, 安藤仁, 高橋克典, 國友康夫, Ariella Coler-Reilly, 新谷奈津美, 八木下尚子, 山野嘉久.
  • Organizer: 第2回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都港区（東京大学医科学研究所）
  • Year and Date: 2015-08-22
• [Presentation] Humanized anti-CCR4 antibody KW0761 targets HTLV-1-infected CD4+CCR4+ and CD8+CCR4+ T-cells to treat HAM/TSP. (2015)
  • Author(s): Yamano Y, Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Kunitomo Y, Takahashi K, Tanaka Y, Akiyama H, Hasegawa Y, Utsunomiya A.
  • Organizer: 17th International Conference on Human Retrovirology: HTLV and Related Viruses
  • Place of Presentation: Martinique, Frenchi West Indies
  • Year and Date: 2015-06-18
  • Int'l Joint Research
• [Presentation] HTLV-1 Tax induces Th1 master regulator T-bet and thus IFN-γ in CD4+CCR4+ T-cells of virus-associated myelopathy patients. (2015)
  • Author(s): Araya N, Sato T, Tomaru U, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Akiyama H,Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Utsunomiya A, Jacobson S, Yamano Y.
  • Organizer: 17th International Conference on Human Retrovirology: HTLV and Related Viruses
  • Place of Presentation: Martinique, Frenchi West Indies
  • Year and Date: 2015-06-18
  • Int'l Joint Research
• [Presentation] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP. (2015)
  • Author(s): Yamano Y.
  • Organizer: 40Years of Neuroimmunology
  • Place of Presentation: Bethesda, Maryland, USA.
  • Year and Date: 2015-04-19
  • Int'l Joint Research / Invited
• [Presentation] 希少な神経難病：HTLV-1関連脊髄症（HAM）の新薬開発への挑戦 (2014)
  • Author(s): 山野嘉久.
  • Organizer: 第35回日本臨床薬理学会学術総会 シンポジウム24
  • Place of Presentation: 愛媛県（松山市）〔ひめぎんホール〕
  • Year and Date: 2014-12-04
  • Invited
• [Presentation] 難病研究資源バンクにおける収集試料のHLAタイピング実施による難病研究の推進. (2014)
  • Author(s): 夛田まや子, 平田誠, 佐々木光穂, 樋野村亜希子, 前畑みどり, 高橋一朗, 増井徹, 山野嘉久, 吉良潤一, 米田悦啓, 坂手龍一.
  • Organizer: 第23回日本組織適合性学会大会
  • Place of Presentation: 長崎県（長崎市）〔長崎大学坂本キャンパス〕
  • Year and Date: 2014-09-13 – 2014-09-15
• [Presentation] 慢性C型肝炎に対するインターフェロン療法後に、抗アクアポリン4抗体及び抗HTLV-1抗体陽性の脊髄長大病変を呈した49歳女性例. (2014)
  • Author(s): 余郷麻希子，大本周作，向井泰司，安部宏，相澤良夫，高橋利幸，山野嘉久，鈴木正彦.
  • Organizer: 第210回日本神経学会関東・甲信越地方会
  • Place of Presentation: 東京都（千代田区）〔砂防会館〕
  • Year and Date: 2014-09-06
• [Presentation] HAMにおけるTh1様異常T細胞の発生機構および病態への関与 (2014)
  • Author(s): 佐藤知雄、新谷奈津美、安藤仁、山内淳司、國友康夫、高橋克典、斎藤祐美、石川美穂、八木下尚子、山野嘉久.
  • Organizer: 第19回日本神経感染症学会総会学術集会・第26回日本神経免疫学会学術集会合同学術集会
  • Place of Presentation: 石川県（金沢市）〔金沢歌劇座〕
  • Year and Date: 2014-09-04 – 2014-09-06
• [Presentation] HAMにおける抗CCR4抗体療法の有用性およびCCR4+CD8+T細胞の異常に関する検討. (2014)
  • Author(s): 山内淳司, 新谷奈津美, 安藤仁, Ariella Coler-Reilly, 國友康夫, 高橋克典, 八木下尚子, 佐藤知雄, 宇都宮與, 山野嘉久.
  • Organizer: 第19回日本神経感染症学会総会学術集会・第26回日本神経免疫学会学術集会合同学術集会
  • Place of Presentation: 石川県（金沢市）〔金沢歌劇座〕
  • Year and Date: 2014-09-04 – 2014-09-06
• [Presentation] HAM患者登録システム「HAMねっと」を用いた疫学的解析. (2014)
  • Author(s): 山野嘉久, 木村美也子, 八木下尚子, 鈴木弘子, 石川美穂, 小池美佳子, 齊藤 祐美, 新谷奈津美, 佐藤知雄, 高田礼子.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HTLV-1関連脊髄症（HAM）の臨床的評価指標の有用性に関する検討. (2014)
  • Author(s): 佐藤知雄, 井上永介, 新谷奈津美, 高橋克典, 國友康夫, Ariella Coler-Reilly, 山内淳司, 八木下尚子, 山野嘉久.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HTLV-1によるHTLV-1関連脊髄症（HAM）病原性T細胞の発生機構の解析. (2014)
  • Author(s): 新谷奈津美, 佐藤知雄, 安藤仁, 外丸詩野, Ariella Coler-Reilly, 八木下尚子, 山内淳司, 長谷川温彦, 神奈木真理, 田中勇悦, 宇都宮與, 山野嘉久.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HTLV-1関連脊髄症(HAM)患者登録システム「HAMねっと」の患者満足度調査. (2014)
  • Author(s): 八木下尚子, 有福厚孝, 菊池崇之, 木村未祐奈, 佐藤健太郎, 石川美穂, 鈴木弘子, 小池美佳子, 齊藤祐美, 新谷奈津美, 佐藤知雄, 木村美也子, 高田礼子, 山野嘉久.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HAMにおける抗CCR4抗体療法の有用性およびCCR4+CD8+T細胞の異常に関する検討. (2014)
  • Author(s): 山内淳司, 新谷奈津美, 安藤仁, 國友康夫, 高橋克典, Ariella Coler-Reilly, 八木下尚子, 佐藤知雄, 宇都宮與, 山野嘉久.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HAMの歩行不安定症に対する歩行改善プログラムに関する検討. (2014)
  • Author(s): 遠藤寿子, 中島孝, 池田哲彦, 大田健太郎, 會田泉, 米持洋介, 山野嘉久.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HTLV-1キャリアに合併した関節リウマチに対する生物学的製剤の使用でHTLV-1ぶどう膜炎とHTLV-1関連脊髄症が悪化した1例. (2014)
  • Author(s): 寺田裕紀子, 鴨居功樹, 山野ちなみ, 山野嘉久.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] CD4陽性T細胞を用いた膜プロテオーム解析によるHTLV-1関連脊髄症に対する新規治療標的分子の探索. (2014)
  • Author(s): 石原誠人, 新谷奈津美, 佐藤知雄, 藤井理沙, 最知直美, 宇都宮與, 山野嘉久, 菅野純夫, 植田幸嗣.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所〕
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HAMの炎症慢性化におけるastrocyteを介した炎症悪性ループの重要性. (2014)
  • Author(s): 山野嘉久.
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡県（福岡市）〔福岡国際会議場〕
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] 患者QOLの改善に向けた患者レジストリの満足度調査. (2014)
  • Author(s): 菊池崇之, 有福厚孝, 木村未祐奈, 佐藤健太郎, 本橋隆子, 木村美也子, 網中雅仁, 高田礼子, 八木下尚子, 山野嘉久.
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡県（福岡市）〔福岡国際会議場〕
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] The role of E3 ubiquitin ligase Synoviolin in bone destruction of rheumatoid arthritis. (2014)
  • Author(s): Yagishita N, Aratani S, Fujita H, Yamano Y, Nishioka K, Nakajima T.
  • Organizer: 第58回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京都（港区）〔グランドプリンスホテル新高輪〕
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Quantitative membrane proteome profiling to discover therapeutic targets for adult T-cell leukemia (ATL). (2014)
  • Author(s): Ishihara M, Araya N, Sato T, Fujii R, Tatsuguchi A, Saichi N, Nakagawa H, Yamano Y, Ueda K.
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] CXCL10 and Neopterin in cerebrospinal fluid are Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (2013)
  • Author(s): Yamano Y., Sato T., Ando H., Araya N., Yagishita N., Yamauchi J., Coler-Reilly A., Utsunomiya A., Jacobson S., Izumo S.
  • Organizer: The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
  • Place of Presentation: Montreal, Canada
• [Presentation] Virus-induced CXCL10-CXCR3 positive feedback loop via astrocytes is critical for maintaining chronic inflammatory lesions in HAM/TSP. (2013)
  • Author(s): Sato T., Ando H., Tomaru U., Yoshida M., Utsunomiya A., Yamauchi J., Araya N., Yagishita N., Coler-Reilly A., Jacobson S., Yamano Y.
  • Organizer: The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
  • Place of Presentation: Montreal, Canada
• [Presentation] CXCL10, CXCL9 and Neopterin in cerebrospinal fluid as Candidate Prognostic Biomarkers for HAM/TSP. (2013)
  • Author(s): Yamano Y., Sato T., Coler-Reilly A., Ando H., Araya N., Yagishita N., Yamauchi J., Utsunomiya A., Jacobson S., Izumo S.
  • Organizer: The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
  • Place of Presentation: Montreal, Canada
• [Presentation] Nation-wide epidemiological study in Japan on HTLV-1 associated myelopathy/tropical spastic paraparesis using HAM-net, a novel patient registration system. (2013)
  • Author(s): Coler-Reilly A., Hashimoto M., Yagishita N., Sato T., Ando H., Yamauchi J., Araya N., Kimura M., Yamano Y., Takata A.
  • Organizer: The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
  • Place of Presentation: Montreal, Canada
• [Presentation] Label free quantitative proteome analysis on cerebrospinal fluid to discover severity grade markers for Human T-cell leukemia virus type 1 associated myelopathy/tropic spastic paraparesis (HAM/TSP). (2013)
  • Author(s): Ishihara M, Araya N, Sato T, Fujii R, Tatsuguchi A, Saichi N, Nakagawa H, Yamano Y, Ueda K.
  • Organizer: HUPO 2013 12th Annual World Congress
  • Place of Presentation: Kanagawa, Japan
• [Presentation] HAMにおける抗CCR4抗体製剤の有用性に関する検討 (2013)
  • Author(s): 山野嘉久, 山内淳司, 新谷奈津美, 安藤仁, Ariella Color-Reilly, 八木下尚子, 宇都宮與, 佐藤知雄.
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 山口県（下関市）〔海峡メッセ下関〕
• [Presentation] 同種造血幹細胞移植後ATL患者からの新規HTLV-1特異的CD4エピトープの同定（Identification of novel HTLV-1-specific CD4 epitopes in ATL patients after hematopoietic stem cell transplantation.） (2013)
  • Author(s): Hasegawa A., Tamai Y., Takamori A., Sasada A., Tanosaki R., Choi I., Utsunomiya A., Suehiro Y., Maeda Y., Yamano Y., Uike N., Kannagi M.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 神奈川県（横浜市）〔パシフィコ横浜〕
• [Presentation] 成人T細胞白血病ウイルス関連疾患における新規治療標的同定を目的とした定量膜プロテオームプロファイリング. (2013)
  • Author(s): 石原誠人、新谷奈津美、佐藤知雄、宇都宮與、中川英刀、山野嘉久、植田幸嗣.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 神奈川県（横浜市）〔パシフィコ横浜〕
• [Presentation] HTLV-1関連脊髄症（HAM）の治療標的としてのCCR4+CD4+T細胞 (2013)
  • Author(s): 佐藤知雄、新谷奈津美、安藤仁、Ariella Coler-Reilly、山内淳司、八木下尚子、山野嘉久.
  • Organizer: 第6回HTLV-1研究会・シンポジウム
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所講堂〕
• [Presentation] Development of novel molecular targeted therapies for HAM/TSP. (2013)
  • Author(s): Yamano Y.
  • Organizer: 第6回HTLV-1研究会・シンポジウム／第3回HTLV-1国際シンポジウム
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所講堂〕
  • Invited
• [Presentation] 脳脊髄液プロテオーム解析によるヒトTリンパ好性ウイルス関連脊髄症(HAM/TSP)に対する重症度診断アルゴリズムの構築. (2013)
  • Author(s): 石原 誠人、新谷奈津美、佐藤知雄、山野嘉久、中川英刀、植田幸嗣.
  • Organizer: 第6回HTLV-1研究会・シンポジウム
  • Place of Presentation: 東京都（港区）〔東京大学医科学研究所講堂〕
• [Book] 神経関連感染症 最新医学 別冊 (2014)
  • Author(s): 山野嘉久.
  • Publisher: 最新医学社
• [Remarks] 聖マリアンナ医科大学難病治療研究センター
  • URL: http://nanchiken.jp/
• [Remarks] 聖マリアンナ医科大学難病治療研究センター 病因・病態解析部門
  • URL: http://nanchiken.jp/byouin/achievement/
• [Remarks] 聖マリアンナ医科大学 難病治療研究センター 病因・病態解析部門
  • URL: http://nanchiken.jp/
• [Patent(Industrial Property Rights)] Production method of gamma delta T cell and use thereof (2015)
  • Inventor(s): Yamano Y, Seino K, Muto M.
  • Industrial Property Rights Holder: Yamano Y, Seino K, Muto M.
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-10-13
  • Overseas
• [Patent(Industrial Property Rights)] γδＴ細胞の製造方法および医薬 (2014)
  • Inventor(s): 山野嘉久、清野研一郎、武藤真人.
  • Industrial Property Rights Holder: 山野嘉久、清野研一郎、武藤真人.
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-209669
  • Filing Date: 2014-10-14
• [Patent(Industrial Property Rights)] ヒトTリンパ好性ウイルス－１（HTLV-1）関連脊髄症（HAM/TSP）の検査方法、及び検査用キット (2014)
  • Inventor(s): 山野嘉久、植田幸嗣、石原誠人.
  • Industrial Property Rights Holder: 山野嘉久、植田幸嗣、石原誠人.
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-226719
  • Filing Date: 2014-11-07