Membrane rafts impairments in neurological disorders showing dementia
Project/Area Number |
25461295
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
|
Research Institution | Fujita Health University |
Principal Investigator |
MUTOH Tatsuro 藤田保健衛生大学, 医学部, 教授 (60190857)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | アルツハイマー病 / 認知症 / 糖脂質 / 神経細胞死 / 細胞膜ラフト / 細胞内情報伝達 / 中性糖脂質 / ガングリオシド / 脂質ラフト / 神経栄養因子受容体 / 抗中性糖脂質抗体 / プレセニリン1 / 神経栄養因子 / マクロファージ |
Outline of Final Research Achievements |
Previous studies have shown that patients with Alzheimer's disease (AD) exhibit abonormal brain glycolipids compositions and quantities. In this study, we forcused on the integrity and function of the membrane rafts of neuronal cells expressing mutated presenilin-1. We also performed lipid analyses of human brains of AD patients and found decreased amount of neutral glycolipids and gangliosides in the patients compared with those of control subjects. Furthermore, we reconstituted glycolipids abnormality found in patients' brain by use of the specific inhibitors for synthesizing or catabolizing enzymes and/or exogenous addition of glycolipids in culture medium of PC12 cells. During the course of the study, we found novel antibodies against neutral glycolipids. By use of these new autoantibodies against neutral lipids, we examined the specific roles of neutral glycolipids on the function of the rafts in neuronal cells.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Phase II Trial of Intravenous Low-Dose Granulocyte Colony-Stimulating Factor in Acute Ischemic Stroke2016
Author(s)
Mizuma A, Yamashita T, Kono S, Nakayama T, Baba Y, Itoh S, Asakura K, Niimi Y, Asahi T, Kanemaru K, Mutoh T, Kuroda S, Kinouchi H, Abe K, Takizawa S.
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Journal Title
J Stroke Cerebrovasc Dis
Volume: Epub ahead of print
Issue: 6
Pages: 0-0
DOI
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Neurotropin promotes NGF signaling through interaction of GM1 ganglioside with Trk neurotrophin receptor in PC12 cells2015
Author(s)
Fukuda Y, Fukui T, Hikichi C, Ishikawa T, Murate K, Adachi T, Imai H, Fukuhara K, Ueda A, Kaplan AP, Mutoh T
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Journal Title
Brain Research
Volume: 1596
Pages: 13-21
DOI
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Peer Reviewed / Open Access
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[Journal Article] Histone deacetylase inhibitor attenuates neurotoxicology of clioquinol in PC12 cells.2015
Author(s)
Fukui T, Asakura K, Hikichi C, Ishikawa T, Murai R, Hirota S, Murate KI, Kizawa M, Ueda A, Ito S, Mutoh T.
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Toxicology
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Pages: 112-118
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Peer Reviewed / Acknowledgement Compliant
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Author(s)
Kitaguchi N, Hasegawa M, Ito S, Kawaguchi K, Nakai S, Suzuki N, Shimano Y, Ishida O, Kushimoto H, Kata M, Koide S, Kanayama K, Kato T, Ito K, Mutoh T, Sugiyama S, Yuzawa Y.
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Journal Title
J Neural Transm
Volume: 122(11)
Issue: 11
Pages: 1593-607
DOI
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Peer Reviewed / Acknowledgement Compliant
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Author(s)
Mizutani Y, Ito S, Murate K, Hirota S, Fukui T, Hikichi C, Ishikawa T, Shima S, Ueda A, Kizawa M, Asakura K, Mutoh T
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Journal Title
J Neurol Sci
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Issue: 1-2
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Peer Reviewed / Open Access
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Author(s)
Ikeda M, Miki T, Atsumi M, Inagaki A, Mizuguchi E, Meguro M, Kanamori D, Nakagawa K, Watanabe R, Mano K, Aihara A, Hane Y, Mutoh T, Matsuo K.
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Geriatr Nurs
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Author(s)
Uemura N, Sugano K, Hiraishi H, Shimada K, Goto S, Uchiyama S, Okada Y, Origasa H, Ikeda Y; MAGIC Study Group. Collaborators: Asakura K, Mutoh T et al.
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Journal Title
J Gastroenterol
Volume: 49(5)
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Pages: 814-24
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Peer Reviewed
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第141回 日本神経学会東海北陸地方会
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