Search of miRNA profile analysis and specific miRNA in familial Parkinson's disease
| Project/Area Number |
25461304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Department of Clinical Research, National Hospital Organization Tokushima National Hospital |
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Principal Investigator |
Yukiko Kurota 独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, 研究員 (70398014)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUI TAKAO 独立行政法人国立病院機構・徳島病院, 臨床研究部, 臨床研究部長 (80294726)
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| Co-Investigator(Renkei-kenkyūsha) |
KAJI RYUJI 徳島大学, 大学院臨床神経科学, 教授 (00214304)
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| Research Collaborator |
TAKAHASHI RYOSUKE
SAWADA TOMOYO
FUJIMOTO MIKI
SOGO MASAKO
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | パーキンソン病 / miRNA / パーキン / 家族性パーキンソン病 / 病態 |
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| Outline of Final Research Achievements |
We are in the course of study the parkin function, to identify the unknown protein that carries Parkin to mitochondria (Klokin1).Parkin has been found to promote the biogenesis of mitochondrial genes. This study, parkin was examined whether may be involved in transcription and replication of mitochondrial and nuclear genes through the miRNA.We result of study of the association between Parkin and Drosha complexes by immunoprecipitation, Drosha protein was also detected in the mitochondrial fraction.Further Drosha bound to Parkin was detected in the nuclear and mitochondrial fractions.This result could have occurred miRNA processing is also in the mitochondria has been suggested.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability2015
Author(s)
.Kawarai T, Tajima A, Kuroda Y, Saji N, Orlacchio A, Terasawa H, Shimizu H, Kita Y, Izumi Y, Mitsui T, Imoto I, Kaji R.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 8
Pages: 309828-309828
Related Report
Peer Reviewed
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