| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
The present study was undertaken to evaluate the ability of electrogastrogram (EGG) and other clinical tests to distinguish between DLB and AD. We performed electrogastrogram recording, MIBG myocardial scintigraphy, olfactory test (OSIT-J), head-up tilt test and heat rate variability measurement in 11 DLB and 17 AD patients and 20 healthy controls. Gastric myoelectrical activity was measured using a portable EGG recorder. The AD patients and controls showed 3 cycle /min of regular slow waves in EGG meanwhile the DLB patients presented irregular slow waves. The instability coefficient of the dominant frequency, an index of gastric slow wave irregularity, was significantly higher in the DLB patients than the AD patients and controls. From the aspect of differentiation between DLB and AD, EGG showed similar sensitivity and specificity to MIBG scintigraphy. Olfactory test and cardiovascular autonomic function tests were not useful to distinguish between DLB and AD.
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