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Establishement of objective assessment of neuropathic pain in diabetes

Research Project

Project/Area Number 25461308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionChiba University

Principal Investigator

MISAWA Sonoko  千葉大学, 医学部附属病院, 講師 (30375753)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords糖尿病神経障害 / 神経障害性疼痛 / 臨床神経生理 / 脳機能画像 / 神経生理 / 糖尿病性神経障害
Outline of Final Research Achievements

Diabetes is the most frequent cause of neuropathy in developed countries. Diabetic neuropathy causes severe pain in advanced patients. However most patients are not treated appropriately, because objective evaluation of neuropathic pain has not been available. This study aimed to establish evaluation of the pathophysiology and objective assessment of pain in diabetic neuropathy.
We performed clinical assessment, neurophysiological testing, and single photon emission computed tomography in diabetic patients with or without pain. We have finished patient recruitment and are preparing to analyze the obtained data.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) (of which Invited: 1 results)

  • [Journal Article] Altered axonal excitability properties and nerve2015

    • Author(s)
      Mitsuma S, Misawa S, Shibuya K, Isose S, Sekiguchi Y, Iwai Y, Beppu M,
    • Journal Title

      Clin Neurophysiol

      Volume: 印刷中 Issue: 10 Pages: 2014-2018

    • DOI

      10.1016/j.clinph.2015.01.018

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different electrophysiological profiles and treatment response in 'typical' and 'atypical' chronic inflammatory demyelinating polyneuropathy.2014

    • Author(s)
      Kuwabara S, Isose S, Mori M, Mitsuma S, Sawai S, Beppu M, Sekiguchi Y, Misawa S
    • Journal Title

      Journal of Neurology, Neurosurgery and Psychiatry

      Volume: - Issue: 10 Pages: 1-6

    • DOI

      10.1136/jnnp-2014-308452

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Duration of the distal compound muscle action potential for diagnosis of chronic inflammatory demyelinating polyneuropathy: Effects of low-cut filters2014

    • Author(s)
      Isose S, Misawa S, Sonoo M, Shimuzu T, Oishi C, Shibuya K, Nasu S, Sekiguchi
    • Journal Title

      J Clin Neurophysiol

      Volume: 31 Issue: 5 Pages: 441

    • DOI

      10.1097/wnp.0000000000000045

    • URL

      https://pure.teikyo.jp/en/publications/d6d76d6a-1867-4c9f-b341-cff71f7eb80f

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bortezomib-induced neuropathy: axonal membrane depolarization precedes development of neuropathy2014

    • Author(s)
      Nasu S, Misawa S, Nakaseko C, Shibuya K, Isose S, Sekiguchi Y, Mitsuma, Ohmori S, Iwai Y, Beppu M, Shimizu N, Ohwada C, Takeda Y, Fujimaki Y, Kuwabara S S,
    • Journal Title

      Clinical Neurophysiology

      Volume: 125 Issue: 2 Pages: 381-387

    • DOI

      10.1016/j.clinph.2013.07.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Patterns of sensory nerve conduction abnormalities in Fisher syndrome : more predominant involvement of group Ia afferents than skin afferents2013

    • Author(s)
      Sekiguchi Y, Misawa S, Shibuya K, Mitsuma S, Hirano S, Ohmori S, Koga S, Iwai Y, Beppu M, Kuwabara S
    • Journal Title

      Clin Neurophysiol

      Volume: 124(7) Issue: 7 Pages: 1465-9

    • DOI

      10.1016/j.clinph.2013.01.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖尿病神経障害の軸索特性における器質的変化の影響2015

    • Author(s)
      渡辺慶介、三澤園子、関口 縁、別府 美奈子、岩井雄太、網野 寛、磯瀬沙希里、大森茂樹、桑原 聡
    • Organizer
      第45回日本臨床神経生理会学術大会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖尿病神経障害における軸索特性の変化2015

    • Author(s)
      渡辺慶介、三澤園子、関口 縁、三津間さつき、岩井雄太、磯瀬沙希里、大森茂樹、網野 寛、澁谷和幹、桑原 聡
    • Organizer
      第56回 日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県・新潟市)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖尿病神経障害における軸索特性の変化2014

    • Author(s)
      渡辺慶介、三澤園子、渋谷和幹、関口縁、三津間さつき、岩井雄太、別府美奈子、磯瀬沙希里、大森茂樹、網野寛、桑原聡
    • Organizer
      日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場・福岡県・福岡市
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖尿病神経障害の経時的評価に軸索機能検査は有用か?2014

    • Author(s)
      渡辺慶介、三澤園子、澁谷和幹、関口縁、三津間さつき、岩井雄太、別府美奈子、磯瀬沙希里、大森茂樹、桑原聡
    • Organizer
      日本神経学会学術集会
    • Place of Presentation
      福岡国際会議場・福岡県・福岡市
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖尿病神経障害の経時変化の評価に軸索機能検査は有用である2013

    • Author(s)
      渡辺慶介、三澤園子、澁谷和幹、関口縁、別府美奈子、三間さつき、岩井雄太、磯瀬沙希里、大森茂樹、桑原聡
    • Organizer
      第43回 日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化ホール
    • Related Report
      2013 Research-status Report
  • [Presentation] 教育講演:糖尿病性神経障害:軸索興奮性の視点から2013

    • Author(s)
      三澤園子
    • Organizer
      第43回 日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化ホール
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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