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Elucidating the mechanism of abnormal processing of temporal information in patients with neurological disorders

Research Project

Project/Area Number 25461309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionThe University of Tokyo

Principal Investigator

Terao Yasuo  東京大学, 医学部附属病院, 講師 (20343139)

Co-Investigator(Kenkyū-buntansha) HANAJIMA Ritsuko  北里大学, 神経内科, 診療准教授 (80396738)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords時間認知 / 時間再生 / 時間的統合 / 大脳基底核 / 小脳 / 神経疾患 / パーキンソン病 / 内因性クロック / 脊髄小脳変性症 / 反応時間
Outline of Final Research Achievements

Previous studies suggest that temporal information processing is abnormal in patients with neurological disorders, including Parkinson’s disease (PD). We used three tasks to elucidate and characterize the abnormal processing. One tasks was to compare the duration of two sounds (S1 and S2) presented in succession. Another was to reproduce the duration of sound just presented by pressing a button for the same duration of time. The third was to tap the keyboard in synchrony with the tones (duration: 50 ms) that were regularly presented with an interval of 200ms to 5000ms. In all three tasks, performance differed between PD patients and age-mathced normal subjects. We suggest that processing of temporal information is different between PD patients and normal subjects, especially when the time to be processed has a duration longer and shorter than several seconds.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (5 results)

  • [Journal Article] Is multiple system atrophy with cerebellar ataxia (MSA-C) like spinocerebellar ataxia and multiple system atrophy with parkinsonism (MSA-P) like Parkinson's disease? - A saccade study on pathophysiology.2016

    • Author(s)
      Terao Y, Fukuda H, Tokushige S, Inomata-Terada S, Yugeta A, Hamada M, Ichikawa Y, Hanajima R, Ugawa Y.
    • Journal Title

      Clin Neurophysiol.

      Volume: 127(2) Issue: 2 Pages: 1491-502

    • DOI

      10.1016/j.clinph.2015.07.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Saccade abnormalities associated with focal cerebral lesions -How cortical and basal ganglia commands shape saccades in humans-2016

    • Author(s)
      Terao Y, Fukuda H, Tokushuge S, Nomura Y, Hanajima R, Ugawa Y
    • Journal Title

      Clinical Neurophysiology

      Volume: 印刷中 Issue: 8 Pages: 2953-2967

    • DOI

      10.1016/j.clinph.2015.07.041

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Visual Scanning Area is Abnormally Enlarged in Hereditary Pure Cerebellar Ataxia.2015

    • Author(s)
      Matsuda S1, Matsumoto H, Furubayashi T, Fukuda H, Hanajima R, Tsuji S, Ugawa Y, Terao Y.
    • Journal Title

      cerebellum

      Volume: 14 Issue: 2 Pages: 63-71

    • DOI

      10.1007/s12311-014-0600-5

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The 3-second rule in hereditary pure cerebellar ataxia: a synchronized tapping study.2015

    • Author(s)
      Matsuda S1, Matsumoto H1, Furubayashi T2, Hanajima R1, Tsuji S1, Ugawa Y2, Terao Y1.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: e0118592-e0118592

    • DOI

      10.1371/journal.pone.0118592

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Parkinson's disease, l-Dopa and "express" saccades: Superior colliculus dyskinesias?2014

    • Author(s)
      Terao Y, Fukuda H, Ugawa Y, Hikosaka O
    • Journal Title

      Clinical Neurophysiology

      Volume: 125 Issue: 3 Pages: 648-650

    • DOI

      10.1016/j.clinph.2013.07.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of the motor cortical quadripulse transcranial magnetic stimulation (QPS) on the contralateral motor cortex and interhemispheric interactions.2014

    • Author(s)
      Tsutsumi R, Hanajima R, Terao Y, Shirota Y, Ohminami S, Shimizu T, Tanaka N, Ugawa Y.
    • Journal Title

      J Neurophysiol

      Volume: 111 Issue: 1 Pages: 26-35

    • DOI

      10.1152/jn.00515.2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bidirectional effects on inter-hemispheric resting-state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation.2013

    • Author(s)
      Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Takao H, Kawakubo Y, Kamio Y, Kato N, Miyashita Y, Kasai K, and Yamasue H.
    • Journal Title

      Human Brain Mapping

      Volume: 35 Issue: 5 Pages: 1896-1905

    • DOI

      10.1002/hbm.22300

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] パーキンソン病患者における時間的統合の限界2015

    • Author(s)
      徳重真一、寺尾安生、松田俊一、佐々木拓也、弓削田晃弘、寺田さとみ、濱田雅、辻 省次、宇川義一
    • Organizer
      第45回日本臨床神経生理学会学術大会
    • Place of Presentation
      大阪府・大阪市
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小脳の時間情報処理の解析2015

    • Author(s)
      寺尾安生、徳重真一、松田俊一、宇川義一
    • Organizer
      第9回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京都・港区
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経疾患における時間情報処理の異常2015

    • Author(s)
      寺尾安生
    • Organizer
      大脳基底核研究会
    • Place of Presentation
      愛知県・犬山市
    • Year and Date
      2015-07-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] パーキンソン病における時間認知障害2014

    • Author(s)
      寺尾 安生、古林 俊晃、徳重 真一、松田 俊一、濱田 雅、堤 涼介、清水 崇宏、田中 信行、寺田 さとみ、花島 律子、松本 英之、辻 省次、宇川 義一
    • Organizer
      第43回日本臨床神経生理学会学大会第55回日本神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Paired TMS: cerebellar stimulation

    • Author(s)
      Terao Y
    • Organizer
      5th Asian-Oceanen International congress of Clinical Neurophysiology
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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